Inhibitory effects of fullerene C60 derivatives on endothelium-derived relaxation in rabbit thoracic aorta

Mitsutoshi Satoh, Tadahiko Mashino, Tetsuo Nagano, Masaaki Hirobe, Issei Takayanagi, Katsuo Koike

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Abstract

Inhibitory effects of newly synthesized fullerene C60 derivatives 1 (C60-bis(N, N-dimethylpyrrolidinium iodide)), 2 (C60-proline-N-acetic acid) and 3 (C60-ethylenediamine-N, N′-diacetic acid) on acetylcholine-induced relaxation in endothelium-intact rabbit thoracic aorta precontracted by phenylephrine (10-6 M) were studied. Fullerene C60 derivative 1 (3 × 10-6 M), 2 (10-5 M) and 3 (10-5 M) reduced the maximum amplitude of the acetylcholine-induced relaxation without significantly changing the pD2 values obtained from the concentration - response curves. In the presence of fullerene C60 derivative 1 (10-5 M) the acetylcholine-induced relaxation was eliminated and an acetylcholine-induced contraction was observed. These results suggest that fullerene C60 derivative 1 strongly inhibits endothelium (nitric oxide)-dependent acetylcholine-induced relaxation in thoracic aorta of rabbit.

Original languageEnglish
Pages (from-to)141-151
Number of pages11
JournalFullerene Science and Technology
Volume9
Issue number2
DOIs
Publication statusPublished - 2001 Jan 1
Externally publishedYes

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Keywords

  • Endothelium
  • Fullerene C derivative
  • Nitric oxide (NO)
  • Smooth muscle
  • Thoracic aorta of rabbit

ASJC Scopus subject areas

  • Chemical Engineering(all)

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