Inhibitory effects of fullerene C60 derivatives on endothelium-derived relaxation in rabbit thoracic aorta

M. Satoh, Tadahiko Mashino, T. Nagano, M. Hirobe, I. Takayanagi, K. Koike

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Inhibitory effects of newly synthesized fullerene C60 derivatives 1 (C60-bis(N,N-dimethylpyrrolidinium iodide)), 2 (C60-proline-N-acetic acid) and 3 (C60-ethylenediamine-N, N′-diacetic acid) on acetylcholine-induced relaxation in endothelium-intact rabbit thoracic aorta precontracted by phenylephrine (10-6 M) were studied. Fullerene C60 derivative 1 (3 × 10-6 M), 2 (10-5 M) and 3 (10-5 M) reduced the maximum amplitude of the acetylcholine-induced relaxation without significantly changing the pD2 values obtained from the concentration - response curves. In the presence of fullerene C60 derivative 1 (10-5 M) the acetylcholine-induced relaxation was eliminated and an acetylcholine-induced contraction was observed. These results suggest that fullerene C60 derivative 1 strongly inhibits endothelium (nitric oxide)-dependent acetylcholine-induced relaxation in thoracic aorta of rabbit.

Original languageEnglish
Pages (from-to)141-151
Number of pages11
JournalFullerene Science and Technology
Volume9
Issue number2
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

acetylcholine
endothelium
aorta
rabbits
Fullerenes
Acetylcholine
fullerenes
Derivatives
ethylenediamine
Nitric oxide
Acetic acid
Phenylephrine
nitric oxide
acetic acid
Proline
Acetic Acid
iodides
contraction
Nitric Oxide
Acids

Keywords

  • Endothelium
  • Fullerene C derivative
  • Nitric oxide (NO)
  • Smooth muscle
  • Thoracic aorta of rabbit

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

Inhibitory effects of fullerene C60 derivatives on endothelium-derived relaxation in rabbit thoracic aorta. / Satoh, M.; Mashino, Tadahiko; Nagano, T.; Hirobe, M.; Takayanagi, I.; Koike, K.

In: Fullerene Science and Technology, Vol. 9, No. 2, 2001, p. 141-151.

Research output: Contribution to journalArticle

Satoh, M. ; Mashino, Tadahiko ; Nagano, T. ; Hirobe, M. ; Takayanagi, I. ; Koike, K. / Inhibitory effects of fullerene C60 derivatives on endothelium-derived relaxation in rabbit thoracic aorta. In: Fullerene Science and Technology. 2001 ; Vol. 9, No. 2. pp. 141-151.
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