Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3

Haruka Nishimuta, Hisakazu Ohtani, Masayuki Tsujimoto, Kenichiro Ogura, Akira Hiratsuka, Yasufumi Sawada

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Sulfotransferase (SULT) 1A1 and SULT1A3 play important roles in the presystemic inactivation of β2 agonists in the liver and intestine, respectively. The study aimed to investigate the inhibitory effects of grapefruit juice, orange juice, green tea, black tea and oolong tea and their constituents on the activities of SULT1A1 and SULT1A3. The activities of both SULT1A1 and SULT1A3 were significantly inhibited by all the beverages investigated at a concentration of 10%. The beverage constituents were tested in concentration ranges considered to be physiologically relevant. The grapefruit constituent, quercetin, completely inhibited SULT1A1, while quercetin and naringin both partially inhibited SULT1A3. The orange constituents, tangeretin and nobiletin, also completely inhibited SULT1A1. The tea constituents, (-)-epicatechin gallate and (-)-epigallocatechin gallate, both almost completely inhibited SULT1A1 and SULT1A3. Moreover, the theaflavin and thearubigin fractions of black tea both completely inhibited SULT1A1 and strongly inhibited SULT1A3. The inhibitory action of green tea on SULT1A3 was competitive, while that of black tea and oolong tea was mixed competitive/non-competitive. Mechanism-based inhibition was not observed with any beverage. In conclusion, various beverages, especially teas, inhibit the function of SULT1A3, and therefore may have the potential to increase the bioavailability of orally administered substrates of SULT1A3, such as β2 agonists.

Original languageEnglish
Pages (from-to)491-500
Number of pages10
JournalBiopharmaceutics and Drug Disposition
Volume28
Issue number9
DOIs
Publication statusPublished - 2007 Dec
Externally publishedYes

Fingerprint

Sulfotransferases
Beverages
Tea
Protein Isoforms
Citrus paradisi
Quercetin
monoamine-sulfating phenol sulfotransferase
Biological Availability
Intestines

Keywords

  • β-agonists
  • Drug interactions
  • Juice
  • Sulfotransferase
  • Tea

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3. / Nishimuta, Haruka; Ohtani, Hisakazu; Tsujimoto, Masayuki; Ogura, Kenichiro; Hiratsuka, Akira; Sawada, Yasufumi.

In: Biopharmaceutics and Drug Disposition, Vol. 28, No. 9, 12.2007, p. 491-500.

Research output: Contribution to journalArticle

Nishimuta, Haruka ; Ohtani, Hisakazu ; Tsujimoto, Masayuki ; Ogura, Kenichiro ; Hiratsuka, Akira ; Sawada, Yasufumi. / Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3. In: Biopharmaceutics and Drug Disposition. 2007 ; Vol. 28, No. 9. pp. 491-500.
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