Insertion polymorphism of CYP2E1 and urinary N-methylformamide after N,N-dimethylformamide exposure in Japanese workers

Tetsuo Nomiyama; Vincent Haufroid; Jean Pierre Buchet; Hiroyuki Miyauchi; Shigeru Tanaka; Tsuneyuki Yamauchi; Shunichiro Imamiya; Yukio Seki; Kazuyuki Omae; Dominique Lison

doi:10.1007/s004200100252

Insertion polymorphism of CYP2E1 and urinary N-methylformamide after N,N-dimethylformamide exposure in Japanese workers

Tetsuo Nomiyama, Vincent Haufroid, Jean Pierre Buchet, Hiroyuki Miyauchi, Shigeru Tanaka, Tsuneyuki Yamauchi, Shunichiro Imamiya, Yukio Seki, Kazuyuki Omae, Dominique Lison

Department of Preventive Medicine and Public Health

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Objectives: This study examined whether consideration of the *1C/*1D CYP2E1 insertion polymorphism is important for interpreting the biological monitoring of exposure to N,N-dimethylformamide (DMF) in Japanese workers. Methods: The insertion genotype, airborne DMF exposure on the last day of a work week, and NMF in urine sampled just after the last workshift of the week determined in 44 male and female Japanese workers. Results and conclusions: The allelic frequency of this CYP2E1 polymorphism was 0.261 in this Japanese population of workers. The CYP2E1 insertion polymorphism did not contribute to NMF levels even after consideration of BMI or alcohol intake. The results indicate that CYP2E1 insertion polymorphism does not appear to be an important determinant for the interpretation of biological exposure to DMF by the measurement of urinary NMF.

Original language	English
Pages (from-to)	519-522
Number of pages	4
Journal	International Archives of Occupational and Environmental Health
Volume	74
Issue number	7
DOIs	https://doi.org/10.1007/s004200100252
Publication status	Published - 2001

Keywords

Cytochrome P4502E1
Genetic polymorphism
Genotype
N,N-dimethylformamide
Phenotype

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

Access to Document

10.1007/s004200100252

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Nomiyama, T., Haufroid, V., Buchet, J. P., Miyauchi, H., Tanaka, S., Yamauchi, T., Imamiya, S., Seki, Y., Omae, K., & Lison, D. (2001). Insertion polymorphism of CYP2E1 and urinary N-methylformamide after N,N-dimethylformamide exposure in Japanese workers. International Archives of Occupational and Environmental Health, 74(7), 519-522. https://doi.org/10.1007/s004200100252

Insertion polymorphism of CYP2E1 and urinary N-methylformamide after N,N-dimethylformamide exposure in Japanese workers. / Nomiyama, Tetsuo; Haufroid, Vincent; Buchet, Jean Pierre; Miyauchi, Hiroyuki; Tanaka, Shigeru; Yamauchi, Tsuneyuki; Imamiya, Shunichiro; Seki, Yukio; Omae, Kazuyuki; Lison, Dominique.

In: International Archives of Occupational and Environmental Health, Vol. 74, No. 7, 2001, p. 519-522.

Research output: Contribution to journal › Article › peer-review

Nomiyama, T, Haufroid, V, Buchet, JP, Miyauchi, H, Tanaka, S, Yamauchi, T, Imamiya, S, Seki, Y, Omae, K & Lison, D 2001, 'Insertion polymorphism of CYP2E1 and urinary N-methylformamide after N,N-dimethylformamide exposure in Japanese workers', International Archives of Occupational and Environmental Health, vol. 74, no. 7, pp. 519-522. https://doi.org/10.1007/s004200100252

Nomiyama, Tetsuo ; Haufroid, Vincent ; Buchet, Jean Pierre ; Miyauchi, Hiroyuki ; Tanaka, Shigeru ; Yamauchi, Tsuneyuki ; Imamiya, Shunichiro ; Seki, Yukio ; Omae, Kazuyuki ; Lison, Dominique. / Insertion polymorphism of CYP2E1 and urinary N-methylformamide after N,N-dimethylformamide exposure in Japanese workers. In: International Archives of Occupational and Environmental Health. 2001 ; Vol. 74, No. 7. pp. 519-522.

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abstract = "Objectives: This study examined whether consideration of the *1C/*1D CYP2E1 insertion polymorphism is important for interpreting the biological monitoring of exposure to N,N-dimethylformamide (DMF) in Japanese workers. Methods: The insertion genotype, airborne DMF exposure on the last day of a work week, and NMF in urine sampled just after the last workshift of the week determined in 44 male and female Japanese workers. Results and conclusions: The allelic frequency of this CYP2E1 polymorphism was 0.261 in this Japanese population of workers. The CYP2E1 insertion polymorphism did not contribute to NMF levels even after consideration of BMI or alcohol intake. The results indicate that CYP2E1 insertion polymorphism does not appear to be an important determinant for the interpretation of biological exposure to DMF by the measurement of urinary NMF.",

keywords = "Cytochrome P4502E1, Genetic polymorphism, Genotype, N,N-dimethylformamide, Phenotype",

author = "Tetsuo Nomiyama and Vincent Haufroid and Buchet, {Jean Pierre} and Hiroyuki Miyauchi and Shigeru Tanaka and Tsuneyuki Yamauchi and Shunichiro Imamiya and Yukio Seki and Kazuyuki Omae and Dominique Lison",

note = "Funding Information: Acknowledgements The authors acknowledge the excellent technical assistance of F. Toubeau. T.N. was a recipient of a post-doctoral grant from the Fonds National de la Recherche Scientifique (Belgium).",

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AU - Haufroid, Vincent

AU - Buchet, Jean Pierre

AU - Miyauchi, Hiroyuki

AU - Tanaka, Shigeru

AU - Yamauchi, Tsuneyuki

AU - Imamiya, Shunichiro

AU - Seki, Yukio

AU - Omae, Kazuyuki

AU - Lison, Dominique

N1 - Funding Information: Acknowledgements The authors acknowledge the excellent technical assistance of F. Toubeau. T.N. was a recipient of a post-doctoral grant from the Fonds National de la Recherche Scientifique (Belgium).

PY - 2001

Y1 - 2001

N2 - Objectives: This study examined whether consideration of the *1C/*1D CYP2E1 insertion polymorphism is important for interpreting the biological monitoring of exposure to N,N-dimethylformamide (DMF) in Japanese workers. Methods: The insertion genotype, airborne DMF exposure on the last day of a work week, and NMF in urine sampled just after the last workshift of the week determined in 44 male and female Japanese workers. Results and conclusions: The allelic frequency of this CYP2E1 polymorphism was 0.261 in this Japanese population of workers. The CYP2E1 insertion polymorphism did not contribute to NMF levels even after consideration of BMI or alcohol intake. The results indicate that CYP2E1 insertion polymorphism does not appear to be an important determinant for the interpretation of biological exposure to DMF by the measurement of urinary NMF.

AB - Objectives: This study examined whether consideration of the *1C/*1D CYP2E1 insertion polymorphism is important for interpreting the biological monitoring of exposure to N,N-dimethylformamide (DMF) in Japanese workers. Methods: The insertion genotype, airborne DMF exposure on the last day of a work week, and NMF in urine sampled just after the last workshift of the week determined in 44 male and female Japanese workers. Results and conclusions: The allelic frequency of this CYP2E1 polymorphism was 0.261 in this Japanese population of workers. The CYP2E1 insertion polymorphism did not contribute to NMF levels even after consideration of BMI or alcohol intake. The results indicate that CYP2E1 insertion polymorphism does not appear to be an important determinant for the interpretation of biological exposure to DMF by the measurement of urinary NMF.

KW - Cytochrome P4502E1

KW - Genetic polymorphism

KW - Genotype

KW - N,N-dimethylformamide

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