Insertion polymorphism of CYP2E1 and urinary N-methylformamide after N,N-dimethylformamide exposure in Japanese workers

Tetsuo Nomiyama, Vincent Haufroid, Jean Pierre Buchet, Hiroyuki Miyauchi, Shigeru Tanaka, Tsuneyuki Yamauchi, Shunichiro Imamiya, Yukio Seki, Kazuyuki Omae, Dominique Lison

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Abstract

Objectives: This study examined whether consideration of the *1C/*1D CYP2E1 insertion polymorphism is important for interpreting the biological monitoring of exposure to N,N-dimethylformamide (DMF) in Japanese workers. Methods: The insertion genotype, airborne DMF exposure on the last day of a work week, and NMF in urine sampled just after the last workshift of the week determined in 44 male and female Japanese workers. Results and conclusions: The allelic frequency of this CYP2E1 polymorphism was 0.261 in this Japanese population of workers. The CYP2E1 insertion polymorphism did not contribute to NMF levels even after consideration of BMI or alcohol intake. The results indicate that CYP2E1 insertion polymorphism does not appear to be an important determinant for the interpretation of biological exposure to DMF by the measurement of urinary NMF.

Original languageEnglish
Pages (from-to)519-522
Number of pages4
JournalInternational Archives of Occupational and Environmental Health
Volume74
Issue number7
DOIs
Publication statusPublished - 2001

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Keywords

  • Cytochrome P4502E1
  • Genetic polymorphism
  • Genotype
  • N,N-dimethylformamide
  • Phenotype

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Nomiyama, T., Haufroid, V., Buchet, J. P., Miyauchi, H., Tanaka, S., Yamauchi, T., Imamiya, S., Seki, Y., Omae, K., & Lison, D. (2001). Insertion polymorphism of CYP2E1 and urinary N-methylformamide after N,N-dimethylformamide exposure in Japanese workers. International Archives of Occupational and Environmental Health, 74(7), 519-522. https://doi.org/10.1007/s004200100252