Abstract
Objectives: This study examined whether consideration of the *1C/*1D CYP2E1 insertion polymorphism is important for interpreting the biological monitoring of exposure to N,N-dimethylformamide (DMF) in Japanese workers. Methods: The insertion genotype, airborne DMF exposure on the last day of a work week, and NMF in urine sampled just after the last workshift of the week determined in 44 male and female Japanese workers. Results and conclusions: The allelic frequency of this CYP2E1 polymorphism was 0.261 in this Japanese population of workers. The CYP2E1 insertion polymorphism did not contribute to NMF levels even after consideration of BMI or alcohol intake. The results indicate that CYP2E1 insertion polymorphism does not appear to be an important determinant for the interpretation of biological exposure to DMF by the measurement of urinary NMF.
| Original language | English |
|---|---|
| Pages (from-to) | 519-522 |
| Number of pages | 4 |
| Journal | International Archives of Occupational and Environmental Health |
| Volume | 74 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2001 |
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Keywords
- Cytochrome P4502E1
- Genetic polymorphism
- Genotype
- N,N-dimethylformamide
- Phenotype
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis
Cite this
Insertion polymorphism of CYP2E1 and urinary N-methylformamide after N,N-dimethylformamide exposure in Japanese workers. / Nomiyama, Tetsuo; Haufroid, Vincent; Buchet, Jean Pierre; Miyauchi, Hiroyuki; Tanaka, Shigeru; Yamauchi, Tsuneyuki; Imamiya, Shunichiro; Seki, Yukio; Omae, Kazuyuki; Lison, Dominique.
In: International Archives of Occupational and Environmental Health, Vol. 74, No. 7, 2001, p. 519-522.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Insertion polymorphism of CYP2E1 and urinary N-methylformamide after N,N-dimethylformamide exposure in Japanese workers
AU - Nomiyama, Tetsuo
AU - Haufroid, Vincent
AU - Buchet, Jean Pierre
AU - Miyauchi, Hiroyuki
AU - Tanaka, Shigeru
AU - Yamauchi, Tsuneyuki
AU - Imamiya, Shunichiro
AU - Seki, Yukio
AU - Omae, Kazuyuki
AU - Lison, Dominique
PY - 2001
Y1 - 2001
N2 - Objectives: This study examined whether consideration of the *1C/*1D CYP2E1 insertion polymorphism is important for interpreting the biological monitoring of exposure to N,N-dimethylformamide (DMF) in Japanese workers. Methods: The insertion genotype, airborne DMF exposure on the last day of a work week, and NMF in urine sampled just after the last workshift of the week determined in 44 male and female Japanese workers. Results and conclusions: The allelic frequency of this CYP2E1 polymorphism was 0.261 in this Japanese population of workers. The CYP2E1 insertion polymorphism did not contribute to NMF levels even after consideration of BMI or alcohol intake. The results indicate that CYP2E1 insertion polymorphism does not appear to be an important determinant for the interpretation of biological exposure to DMF by the measurement of urinary NMF.
AB - Objectives: This study examined whether consideration of the *1C/*1D CYP2E1 insertion polymorphism is important for interpreting the biological monitoring of exposure to N,N-dimethylformamide (DMF) in Japanese workers. Methods: The insertion genotype, airborne DMF exposure on the last day of a work week, and NMF in urine sampled just after the last workshift of the week determined in 44 male and female Japanese workers. Results and conclusions: The allelic frequency of this CYP2E1 polymorphism was 0.261 in this Japanese population of workers. The CYP2E1 insertion polymorphism did not contribute to NMF levels even after consideration of BMI or alcohol intake. The results indicate that CYP2E1 insertion polymorphism does not appear to be an important determinant for the interpretation of biological exposure to DMF by the measurement of urinary NMF.
KW - Cytochrome P4502E1
KW - Genetic polymorphism
KW - Genotype
KW - N,N-dimethylformamide
KW - Phenotype
UR - http://www.scopus.com/inward/record.url?scp=17944377379&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=17944377379&partnerID=8YFLogxK
U2 - 10.1007/s004200100252
DO - 10.1007/s004200100252
M3 - Article
C2 - 11697456
AN - SCOPUS:17944377379
VL - 74
SP - 519
EP - 522
JO - International Archives of Occupational and Environmental Health
JF - International Archives of Occupational and Environmental Health
SN - 0340-0131
IS - 7
ER -