@article{2fae492eb06743f6b045e01ad65c9be8,
title = "Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation",
abstract = "Toda et al. demonstrate using conditional knockout models that IL-10 produced in macrophages in response to postprandial signals can cooperate with insulin to suppress hepatic gluconeogenic gene expression in vitro and in mice. This process is deficient in obese insulin-resistant mice and may be a potential therapeutic target.",
keywords = "Akt, gut microbiome, insulin, interleukin-10, lipopolysaccharide, macrophages, mammalian target of rapamycin, postprandial gluconeogenesis",
author = "Gotaro Toda and Kotaro Soeda and Yukiko Okazaki and Naoki Kobayashi and Yukari Masuda and Naoko Arakawa and Hirotsugu Suwanai and Yosuke Masamoto and Yoshihiko Izumida and Nozomu Kamei and Takayoshi Sasako and Ryo Suzuki and Tetsuya Kubota and Naoto Kubota and Mineo Kurokawa and Kazuyuki Tobe and Tetsuo Noda and Kenya Honda and Domenico Accili and Toshimasa Yamauchi and Takashi Kadowaki and Kohjiro Ueki",
note = "Funding Information: This work has been funded by the Japan Society for the Promotion of Science (grant 16K15488 to K.U. and grants 17K16141 and 19K17954 to G.T.) and the Japan Agency for Medical Research and Development (grant 16fk0210204h0002 to K.U.). We thank Dr. C. Ronald Kahn for sharing the Akt1-floxed mice, Dr. Morris J. Birnbaum for sharing the Akt2-floxed mice, and Dr. Yoshiaki Kido and Dr. Tetsuo Noda for sharing the TSC2-floxed mice. We thank Dr. Noriko Sorimachi, Dr. Sahohime Matsumoto, and Dr. Ichiro Manabe for their excellent assistance and advice on immunological studies. We also thank Ms. Reiko Homma, Ms. Yuko Masaki, Mr. Tomoyuki Ogiwara, and Mr. Takumi Tsukamoto for technical assistance and Ms. Yoshino Tsunashima and Ms. Shiori Odajima for their excellent secretarial work. ",
year = "2020",
month = jul,
day = "2",
doi = "10.1016/j.molcel.2020.04.033",
language = "English",
volume = "79",
pages = "43--53.e4",
journal = "Molecular Cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "1",
}