Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation

Gotaro Toda; Kotaro Soeda; Yukiko Okazaki; Naoki Kobayashi; Yukari Masuda; Naoko Arakawa; Hirotsugu Suwanai; Yosuke Masamoto; Yoshihiko Izumida; Nozomu Kamei; Takayoshi Sasako; Ryo Suzuki; Tetsuya Kubota; Naoto Kubota; Mineo Kurokawa; Kazuyuki Tobe; Tetsuo Noda; Kenya Honda; Domenico Accili; Toshimasa Yamauchi; Takashi Kadowaki; Kohjiro Ueki

doi:10.1016/j.molcel.2020.04.033

Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation

Gotaro Toda, Kotaro Soeda, Yukiko Okazaki, Naoki Kobayashi, Yukari Masuda, Naoko Arakawa, Hirotsugu Suwanai, Yosuke Masamoto, Yoshihiko Izumida, Nozomu Kamei, Takayoshi Sasako, Ryo Suzuki, Tetsuya Kubota, Naoto Kubota, Mineo Kurokawa, Kazuyuki Tobe, Tetsuo Noda, Kenya Honda, Domenico Accili, Toshimasa YamauchiTakashi Kadowaki, Kohjiro Ueki

Department of Microbiology and Immunology

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

Toda et al. demonstrate using conditional knockout models that IL-10 produced in macrophages in response to postprandial signals can cooperate with insulin to suppress hepatic gluconeogenic gene expression in vitro and in mice. This process is deficient in obese insulin-resistant mice and may be a potential therapeutic target.

Original language	English
Pages (from-to)	43-53.e4
Journal	Molecular Cell
Volume	79
Issue number	1
DOIs	https://doi.org/10.1016/j.molcel.2020.04.033
Publication status	Published - 2020 Jul 2

Keywords

Akt
gut microbiome
insulin
interleukin-10
lipopolysaccharide
macrophages
mammalian target of rapamycin
postprandial gluconeogenesis

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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Toda, G., Soeda, K., Okazaki, Y., Kobayashi, N., Masuda, Y., Arakawa, N., Suwanai, H., Masamoto, Y., Izumida, Y., Kamei, N., Sasako, T., Suzuki, R., Kubota, T., Kubota, N., Kurokawa, M., Tobe, K., Noda, T., Honda, K., Accili, D., ... Ueki, K. (2020). Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation. Molecular Cell, 79(1), 43-53.e4. https://doi.org/10.1016/j.molcel.2020.04.033

Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation. / Toda, Gotaro; Soeda, Kotaro; Okazaki, Yukiko; Kobayashi, Naoki; Masuda, Yukari; Arakawa, Naoko; Suwanai, Hirotsugu; Masamoto, Yosuke; Izumida, Yoshihiko; Kamei, Nozomu; Sasako, Takayoshi; Suzuki, Ryo; Kubota, Tetsuya; Kubota, Naoto; Kurokawa, Mineo; Tobe, Kazuyuki; Noda, Tetsuo; Honda, Kenya; Accili, Domenico; Yamauchi, Toshimasa; Kadowaki, Takashi; Ueki, Kohjiro.

In: Molecular Cell, Vol. 79, No. 1, 02.07.2020, p. 43-53.e4.

Research output: Contribution to journal › Article

Toda, G, Soeda, K, Okazaki, Y, Kobayashi, N, Masuda, Y, Arakawa, N, Suwanai, H, Masamoto, Y, Izumida, Y, Kamei, N, Sasako, T, Suzuki, R, Kubota, T, Kubota, N, Kurokawa, M, Tobe, K, Noda, T, Honda, K, Accili, D, Yamauchi, T, Kadowaki, T & Ueki, K 2020, 'Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation', Molecular Cell, vol. 79, no. 1, pp. 43-53.e4. https://doi.org/10.1016/j.molcel.2020.04.033

Toda, Gotaro ; Soeda, Kotaro ; Okazaki, Yukiko ; Kobayashi, Naoki ; Masuda, Yukari ; Arakawa, Naoko ; Suwanai, Hirotsugu ; Masamoto, Yosuke ; Izumida, Yoshihiko ; Kamei, Nozomu ; Sasako, Takayoshi ; Suzuki, Ryo ; Kubota, Tetsuya ; Kubota, Naoto ; Kurokawa, Mineo ; Tobe, Kazuyuki ; Noda, Tetsuo ; Honda, Kenya ; Accili, Domenico ; Yamauchi, Toshimasa ; Kadowaki, Takashi ; Ueki, Kohjiro. / Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation. In: Molecular Cell. 2020 ; Vol. 79, No. 1. pp. 43-53.e4.

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