Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation

Gotaro Toda, Kotaro Soeda, Yukiko Okazaki, Naoki Kobayashi, Yukari Masuda, Naoko Arakawa, Hirotsugu Suwanai, Yosuke Masamoto, Yoshihiko Izumida, Nozomu Kamei, Takayoshi Sasako, Ryo Suzuki, Tetsuya Kubota, Naoto Kubota, Mineo Kurokawa, Kazuyuki Tobe, Tetsuo Noda, Kenya Honda, Domenico Accili, Toshimasa YamauchiTakashi Kadowaki, Kohjiro Ueki

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Toda et al. demonstrate using conditional knockout models that IL-10 produced in macrophages in response to postprandial signals can cooperate with insulin to suppress hepatic gluconeogenic gene expression in vitro and in mice. This process is deficient in obese insulin-resistant mice and may be a potential therapeutic target.

Original languageEnglish
Pages (from-to)43-53.e4
JournalMolecular Cell
Volume79
Issue number1
DOIs
Publication statusPublished - 2020 Jul 2

Keywords

  • Akt
  • gut microbiome
  • insulin
  • interleukin-10
  • lipopolysaccharide
  • macrophages
  • mammalian target of rapamycin
  • postprandial gluconeogenesis

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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  • Cite this

    Toda, G., Soeda, K., Okazaki, Y., Kobayashi, N., Masuda, Y., Arakawa, N., Suwanai, H., Masamoto, Y., Izumida, Y., Kamei, N., Sasako, T., Suzuki, R., Kubota, T., Kubota, N., Kurokawa, M., Tobe, K., Noda, T., Honda, K., Accili, D., ... Ueki, K. (2020). Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation. Molecular Cell, 79(1), 43-53.e4. https://doi.org/10.1016/j.molcel.2020.04.033