Insulin-Like Growth Factor Binding Protein-3 (Igfbp-3) Measurements in the Diagnosis of Growth Hormone Insufficiency and Comparison with Igf-1 Measurements

Yukihiro Hasegawa, Tomonobu Hasegawa, Shinobu Kotoh, Yutaka Tsuchiya

Research output: Contribution to journalArticle

Abstract

To analyze the utility of insulin-like growth factor binding protein-3 (IGFBP-3) radioimmunoassay in the diagnosis of GH insufficiency (GHI) and compare the results of IGFBP-3 and IGF-1, we measured IGF-1 and IGFBP-3 in sera from normalchildren (n=309), short children (n =99) and patients with GHI (n=73). We divided the GHI group into two groups (complete and partial GHD) and divided all the patients into two groups depending upon age (less than and older than 10 years).

Original languageEnglish
Pages (from-to)31-37
Number of pages7
JournalClinical Pediatric Endocrinology
Volume2
Issue number1
DOIs
Publication statusPublished - 1993
Externally publishedYes

Keywords

  • GH
  • growth hormone deficiency (GHD)
  • I GF-1
  • IGFBP-3
  • normal short children (NS)

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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