Integrated Diagnosis Project for Inflammatory Myopathies: An association between autoantibodies and muscle pathology

Shigeaki Suzuki, Akinori Uruha, Norihiro Suzuki, Ichizo Nishino

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Inflammatory myopathies are a heterogeneous group of immune-mediated diseases that involve skeletal muscle as well as many other organs. The classification of inflammatory myopathies has been based on clinical diagnoses, pathological diagnoses, and autoantibodies, independently. The clinical phenotypes of inflammatory myopathies are characterized by various autoantibodies that are originally detected by RNA or protein immunoprecipitation. However, since the correlation between histological features and autoantibodies had not been fully elucidated, we created the “Integrated Diagnosis Project for Inflammatory Myopathies” in October 2010. Based on our work and previous studies, the three major subsets of inflammatory myopathies defined by autoantibodies are immune-mediated necrotizing myopathy (IMNM), antisynthetase syndrome, and dermatomyositis. IMNM is the pathological entity, characterized by significant necrotic and regeneration muscle fibers with minimal or no inflammatory cell infiltration. The detection of autoantibodies against signal recognition particles or 3-hydroxy-3-methylglutaryl-coenzyme A reductase is important for the diagnosis of IMNM. Antisynthetase syndrome, characterized by myositis, interstitial lung disease, skin rash, arthropathy, and Raynaud phenomenon, is the clinical entity based on the presence of aminoacyl transfer RNA synthetase antibodies. Perifascicular necrosis is a distinctive hallmark of antisynthetase syndrome in muscle pathology. The diagnosis of dermatomyositis is usually based on clinical features of typical skin rash. Several autoantibodies are associated with specific subsets of dermatomyositis. Myxovirus resistance A expression in the myofiber cytoplasm has a better sensitivity for the diagnosis of dermatomyositis compared to perifascicular atrophy. The screening of autoantibodies has clinical relevance for managing patients with inflammatory myopathies.

Original languageEnglish
Pages (from-to)693-700
Number of pages8
JournalAutoimmunity Reviews
Volume16
Issue number7
DOIs
Publication statusPublished - 2017 Jul 1

Keywords

  • Autoantibodies
  • Classification
  • Immune-mediated necrotizing myopathy
  • Immunoprecipitation
  • Inflammatory myopathies
  • Muscle pathology

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Integrated Diagnosis Project for Inflammatory Myopathies: An association between autoantibodies and muscle pathology'. Together they form a unique fingerprint.

  • Cite this