Integrated diagnostic strategy for the invasion depth of early gastric cancer by conventional endoscopy and EUS

Yoshiki Tsujii, Motohiko Kato, Takuya Inoue, Shunsuke Yoshii, Kengo Nagai, Tetsuji Fujinaga, Akira Maekawa, Yoshito Hayashi, Tomofumi Akasaka, Shinichiro Shinzaki, Kenji Watabe, Tsutomu Nishida, Hideki Iijima, Masahiko Tsujii, Tetsuo Takehara

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background Although conventional endoscopy (CE) and EUS are considered useful for predicting the invasion depth (T-staging) in early gastric cancer (EGC), no effective diagnostic strategy has been established. Objective To produce simple CE criteria and to elucidate an efficient diagnostic method by combining CE and EUS for accurate T-staging. Design Single-center retrospective analysis. Setting Academic university hospital. Patients Consecutive patients with EGC from April 2007 to March 2012 who underwent CE and EUS before treatment. Interventions Recorded endoscopic images were independently reviewed by 3 observers. The CE criteria for massive invasion were defined, and their utility and the additional value of EUS were assessed. Main Outcome Measurements The accuracy of CE based on the criteria and the accuracy of EUS. Results Two hundred thirty patients were enrolled: 195 with mucosal cancer or cancer in the submucosa less than 500 μm from the muscularis mucosae and 35 with invasive cancers. Multivariate analysis of the CE findings by 1 observer revealed that an irregular surface and a submucosal tumor-like marginal elevation were significantly associated with massive invasion. The simple CE criteria, consisting of those 2 features, had an overall accuracy of 73% to 82% and no significant differences in the diagnostic yield compared with EUS in all observers. CE accurately revealed mucosal cancer, and EUS efficiently salvaged the lesions that were over-diagnosed by CE. With our strategy, which involved the CE criteria and the optimal use of EUS, the comprehensive accuracy exceeded 85% in each observer. Limitations Retrospective, single-center study. Conclusions We demonstrated a practical strategy for T-staging in EGC using simple CE criteria and EUS.

Original languageEnglish
Pages (from-to)452-459
Number of pages8
JournalGastrointestinal Endoscopy
Volume82
Issue number3
DOIs
Publication statusPublished - 2015 Jan 1
Externally publishedYes

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Endoscopy
Stomach Neoplasms
Neoplasms
Mucous Membrane
Multivariate Analysis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

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Integrated diagnostic strategy for the invasion depth of early gastric cancer by conventional endoscopy and EUS. / Tsujii, Yoshiki; Kato, Motohiko; Inoue, Takuya; Yoshii, Shunsuke; Nagai, Kengo; Fujinaga, Tetsuji; Maekawa, Akira; Hayashi, Yoshito; Akasaka, Tomofumi; Shinzaki, Shinichiro; Watabe, Kenji; Nishida, Tsutomu; Iijima, Hideki; Tsujii, Masahiko; Takehara, Tetsuo.

In: Gastrointestinal Endoscopy, Vol. 82, No. 3, 01.01.2015, p. 452-459.

Research output: Contribution to journalArticle

Tsujii, Y, Kato, M, Inoue, T, Yoshii, S, Nagai, K, Fujinaga, T, Maekawa, A, Hayashi, Y, Akasaka, T, Shinzaki, S, Watabe, K, Nishida, T, Iijima, H, Tsujii, M & Takehara, T 2015, 'Integrated diagnostic strategy for the invasion depth of early gastric cancer by conventional endoscopy and EUS', Gastrointestinal Endoscopy, vol. 82, no. 3, pp. 452-459. https://doi.org/10.1016/j.gie.2015.01.022
Tsujii, Yoshiki ; Kato, Motohiko ; Inoue, Takuya ; Yoshii, Shunsuke ; Nagai, Kengo ; Fujinaga, Tetsuji ; Maekawa, Akira ; Hayashi, Yoshito ; Akasaka, Tomofumi ; Shinzaki, Shinichiro ; Watabe, Kenji ; Nishida, Tsutomu ; Iijima, Hideki ; Tsujii, Masahiko ; Takehara, Tetsuo. / Integrated diagnostic strategy for the invasion depth of early gastric cancer by conventional endoscopy and EUS. In: Gastrointestinal Endoscopy. 2015 ; Vol. 82, No. 3. pp. 452-459.
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AU - Tsujii, Yoshiki

AU - Kato, Motohiko

AU - Inoue, Takuya

AU - Yoshii, Shunsuke

AU - Nagai, Kengo

AU - Fujinaga, Tetsuji

AU - Maekawa, Akira

AU - Hayashi, Yoshito

AU - Akasaka, Tomofumi

AU - Shinzaki, Shinichiro

AU - Watabe, Kenji

AU - Nishida, Tsutomu

AU - Iijima, Hideki

AU - Tsujii, Masahiko

AU - Takehara, Tetsuo

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background Although conventional endoscopy (CE) and EUS are considered useful for predicting the invasion depth (T-staging) in early gastric cancer (EGC), no effective diagnostic strategy has been established. Objective To produce simple CE criteria and to elucidate an efficient diagnostic method by combining CE and EUS for accurate T-staging. Design Single-center retrospective analysis. Setting Academic university hospital. Patients Consecutive patients with EGC from April 2007 to March 2012 who underwent CE and EUS before treatment. Interventions Recorded endoscopic images were independently reviewed by 3 observers. The CE criteria for massive invasion were defined, and their utility and the additional value of EUS were assessed. Main Outcome Measurements The accuracy of CE based on the criteria and the accuracy of EUS. Results Two hundred thirty patients were enrolled: 195 with mucosal cancer or cancer in the submucosa less than 500 μm from the muscularis mucosae and 35 with invasive cancers. Multivariate analysis of the CE findings by 1 observer revealed that an irregular surface and a submucosal tumor-like marginal elevation were significantly associated with massive invasion. The simple CE criteria, consisting of those 2 features, had an overall accuracy of 73% to 82% and no significant differences in the diagnostic yield compared with EUS in all observers. CE accurately revealed mucosal cancer, and EUS efficiently salvaged the lesions that were over-diagnosed by CE. With our strategy, which involved the CE criteria and the optimal use of EUS, the comprehensive accuracy exceeded 85% in each observer. Limitations Retrospective, single-center study. Conclusions We demonstrated a practical strategy for T-staging in EGC using simple CE criteria and EUS.

AB - Background Although conventional endoscopy (CE) and EUS are considered useful for predicting the invasion depth (T-staging) in early gastric cancer (EGC), no effective diagnostic strategy has been established. Objective To produce simple CE criteria and to elucidate an efficient diagnostic method by combining CE and EUS for accurate T-staging. Design Single-center retrospective analysis. Setting Academic university hospital. Patients Consecutive patients with EGC from April 2007 to March 2012 who underwent CE and EUS before treatment. Interventions Recorded endoscopic images were independently reviewed by 3 observers. The CE criteria for massive invasion were defined, and their utility and the additional value of EUS were assessed. Main Outcome Measurements The accuracy of CE based on the criteria and the accuracy of EUS. Results Two hundred thirty patients were enrolled: 195 with mucosal cancer or cancer in the submucosa less than 500 μm from the muscularis mucosae and 35 with invasive cancers. Multivariate analysis of the CE findings by 1 observer revealed that an irregular surface and a submucosal tumor-like marginal elevation were significantly associated with massive invasion. The simple CE criteria, consisting of those 2 features, had an overall accuracy of 73% to 82% and no significant differences in the diagnostic yield compared with EUS in all observers. CE accurately revealed mucosal cancer, and EUS efficiently salvaged the lesions that were over-diagnosed by CE. With our strategy, which involved the CE criteria and the optimal use of EUS, the comprehensive accuracy exceeded 85% in each observer. Limitations Retrospective, single-center study. Conclusions We demonstrated a practical strategy for T-staging in EGC using simple CE criteria and EUS.

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