Integration-plot test for peri-stimulus time histograms in human motor units

Junichi Ushiba, S. Honda, Y. Onishi, Y. Tomita, Y. Masakado

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A statistical test is proposed for peri-stimulus time histograms in human motor units for the case where a test stimulus is delivered at a constant interval after a previous discharge. This mathematically described test included the notion of the multiple comparison and thus achieved higher sensitivity than the previously proposed method. With regard to data acquisition, the interval from a sham stimulus to the next discharge was acquired as a control, and the total number of samples was set to be four times as large as that in the test situation to reduce the statistical scattering noise. A newly defined statistical object the integration plot (timewise accumulation of the test histogram without control subtraction) was used for this statistical test. The integration plot had less noise than the cumulative sum (CUSUM) plot (1/√2 in theory) and thus represented the neural effect. To compare this integration-plot test with that of the CUSUM, a simulation experiment that compared two sample histograms (one of which had a faint structural change from 20 ms) was conducted. As a result, the present test succeeded in detecting the onset of the change point earlier (23 ms on average) than the CUSUM test (27 ms on average), and the detection probability was also higher (9 out of 10) than the CUSUM (6 out of 10). It was therefore confirmed experimentally that the present statistical test had higher sensitivity than that of the CUSUM proposed previously.

Original languageEnglish
Pages (from-to)264-271
Number of pages8
JournalMedical and Biological Engineering and Computing
Volume42
Issue number2
DOIs
Publication statusPublished - 2004 Mar

Fingerprint

Statistical tests
Noise
Data acquisition
Scattering
Experiments

Keywords

  • Integration-plot test
  • Multinomial distribution
  • Multiple comparison
  • Peri-stimulus time histograms
  • Probabilistic model
  • Statistics

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Health Information Management
  • Computer Science Applications
  • Computational Theory and Mathematics

Cite this

Integration-plot test for peri-stimulus time histograms in human motor units. / Ushiba, Junichi; Honda, S.; Onishi, Y.; Tomita, Y.; Masakado, Y.

In: Medical and Biological Engineering and Computing, Vol. 42, No. 2, 03.2004, p. 264-271.

Research output: Contribution to journalArticle

Ushiba, Junichi ; Honda, S. ; Onishi, Y. ; Tomita, Y. ; Masakado, Y. / Integration-plot test for peri-stimulus time histograms in human motor units. In: Medical and Biological Engineering and Computing. 2004 ; Vol. 42, No. 2. pp. 264-271.
@article{405c81923f9540be92f5f13edc67e224,
title = "Integration-plot test for peri-stimulus time histograms in human motor units",
abstract = "A statistical test is proposed for peri-stimulus time histograms in human motor units for the case where a test stimulus is delivered at a constant interval after a previous discharge. This mathematically described test included the notion of the multiple comparison and thus achieved higher sensitivity than the previously proposed method. With regard to data acquisition, the interval from a sham stimulus to the next discharge was acquired as a control, and the total number of samples was set to be four times as large as that in the test situation to reduce the statistical scattering noise. A newly defined statistical object the integration plot (timewise accumulation of the test histogram without control subtraction) was used for this statistical test. The integration plot had less noise than the cumulative sum (CUSUM) plot (1/√2 in theory) and thus represented the neural effect. To compare this integration-plot test with that of the CUSUM, a simulation experiment that compared two sample histograms (one of which had a faint structural change from 20 ms) was conducted. As a result, the present test succeeded in detecting the onset of the change point earlier (23 ms on average) than the CUSUM test (27 ms on average), and the detection probability was also higher (9 out of 10) than the CUSUM (6 out of 10). It was therefore confirmed experimentally that the present statistical test had higher sensitivity than that of the CUSUM proposed previously.",
keywords = "Integration-plot test, Multinomial distribution, Multiple comparison, Peri-stimulus time histograms, Probabilistic model, Statistics",
author = "Junichi Ushiba and S. Honda and Y. Onishi and Y. Tomita and Y. Masakado",
year = "2004",
month = "3",
doi = "10.1007/BF02344641",
language = "English",
volume = "42",
pages = "264--271",
journal = "Medical and Biological Engineering and Computing",
issn = "0140-0118",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - Integration-plot test for peri-stimulus time histograms in human motor units

AU - Ushiba, Junichi

AU - Honda, S.

AU - Onishi, Y.

AU - Tomita, Y.

AU - Masakado, Y.

PY - 2004/3

Y1 - 2004/3

N2 - A statistical test is proposed for peri-stimulus time histograms in human motor units for the case where a test stimulus is delivered at a constant interval after a previous discharge. This mathematically described test included the notion of the multiple comparison and thus achieved higher sensitivity than the previously proposed method. With regard to data acquisition, the interval from a sham stimulus to the next discharge was acquired as a control, and the total number of samples was set to be four times as large as that in the test situation to reduce the statistical scattering noise. A newly defined statistical object the integration plot (timewise accumulation of the test histogram without control subtraction) was used for this statistical test. The integration plot had less noise than the cumulative sum (CUSUM) plot (1/√2 in theory) and thus represented the neural effect. To compare this integration-plot test with that of the CUSUM, a simulation experiment that compared two sample histograms (one of which had a faint structural change from 20 ms) was conducted. As a result, the present test succeeded in detecting the onset of the change point earlier (23 ms on average) than the CUSUM test (27 ms on average), and the detection probability was also higher (9 out of 10) than the CUSUM (6 out of 10). It was therefore confirmed experimentally that the present statistical test had higher sensitivity than that of the CUSUM proposed previously.

AB - A statistical test is proposed for peri-stimulus time histograms in human motor units for the case where a test stimulus is delivered at a constant interval after a previous discharge. This mathematically described test included the notion of the multiple comparison and thus achieved higher sensitivity than the previously proposed method. With regard to data acquisition, the interval from a sham stimulus to the next discharge was acquired as a control, and the total number of samples was set to be four times as large as that in the test situation to reduce the statistical scattering noise. A newly defined statistical object the integration plot (timewise accumulation of the test histogram without control subtraction) was used for this statistical test. The integration plot had less noise than the cumulative sum (CUSUM) plot (1/√2 in theory) and thus represented the neural effect. To compare this integration-plot test with that of the CUSUM, a simulation experiment that compared two sample histograms (one of which had a faint structural change from 20 ms) was conducted. As a result, the present test succeeded in detecting the onset of the change point earlier (23 ms on average) than the CUSUM test (27 ms on average), and the detection probability was also higher (9 out of 10) than the CUSUM (6 out of 10). It was therefore confirmed experimentally that the present statistical test had higher sensitivity than that of the CUSUM proposed previously.

KW - Integration-plot test

KW - Multinomial distribution

KW - Multiple comparison

KW - Peri-stimulus time histograms

KW - Probabilistic model

KW - Statistics

UR - http://www.scopus.com/inward/record.url?scp=2342431907&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2342431907&partnerID=8YFLogxK

U2 - 10.1007/BF02344641

DO - 10.1007/BF02344641

M3 - Article

VL - 42

SP - 264

EP - 271

JO - Medical and Biological Engineering and Computing

JF - Medical and Biological Engineering and Computing

SN - 0140-0118

IS - 2

ER -