Integrins and reproductive physiology: Expression and modulation in fertilization, embryogenesis, and implantation

Kou Sueoka, Naoaki Kuji, Shigetatsu Shiokawa, Mamoru Tanaka, Toyohiko Miyazaki, Yasunori Yoshimura

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Objective: To review the available information regarding the role of integrins in reproductive physiology and to discuss their potential clinical implications. Design: Studies that specifically relate to the expression and modulation of integrins in fertilization, embryogenesis, and implantation were identified through the literature and Medline searches. Result(s): Integrins are a class of adhesion molecules that participate in cell-to-cell and cell-to-substratum interactions and are present on essentially all human cells. All mammalian eggs express integrins at their surface, and the integrin α6β1 serves as a sperm receptor that mediates sperm-egg binding. In addition, certain integrin moieties appear to be regulated within the cycling endometrium. Specifically, the expression of β1 integrins in the early proliferative phase is restricted to the glandular epithelium, whereas stromal cells also express β1 integrins in the midsecretory phase. The expression of β1 integrins increases at the time of implantation and remains elevated in the decidua during early pregnancy. A disruption of integrin expression is associated with certain types of infertility in women. The apical surface of the mural trophectoderm does indeed possess functional integrins, and trophoblast interactions with extracellular matrix proteins largely depend on the integrin family of adhesion receptors. Conclusion(s): Integrins play particularly important roles in both fertilization and embryogenesis, including the process of implantation.

Original languageEnglish
Pages (from-to)799-811
Number of pages13
JournalFertility and Sterility
Volume67
Issue number5
DOIs
Publication statusPublished - 1997
Externally publishedYes

Fingerprint

Fertilization
Integrins
Embryonic Development
Decidua
Extracellular Matrix Proteins
Trophoblasts
Stromal Cells
Endometrium
Cell Communication
Infertility
Eggs
Ovum
Spermatozoa
Epithelium

Keywords

  • decidua
  • embryo
  • endometrium
  • implantation
  • Integrin

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Integrins and reproductive physiology : Expression and modulation in fertilization, embryogenesis, and implantation. / Sueoka, Kou; Kuji, Naoaki; Shiokawa, Shigetatsu; Tanaka, Mamoru; Miyazaki, Toyohiko; Yoshimura, Yasunori.

In: Fertility and Sterility, Vol. 67, No. 5, 1997, p. 799-811.

Research output: Contribution to journalArticle

Sueoka, Kou ; Kuji, Naoaki ; Shiokawa, Shigetatsu ; Tanaka, Mamoru ; Miyazaki, Toyohiko ; Yoshimura, Yasunori. / Integrins and reproductive physiology : Expression and modulation in fertilization, embryogenesis, and implantation. In: Fertility and Sterility. 1997 ; Vol. 67, No. 5. pp. 799-811.
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