Inter-evaluator heterogeneity of clinical diagnosis for locally advanced esophageal squamous cell carcinoma

Yasuo Hamamoto, Masanori Nojima, Yu Aoki, Takeshi Suzuki, Kenta Kawasaki, Kenro Hirata, Yasutaka Sukawa, Akira Kasuga, Hirofumi Kawakubo, Hiroya Takeuchi, Koji Murakami, Hiromasa Takaishi, Takanori Kanai, Yuukou Kitagawa

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Abstract

Background: Identifying clinical resectability of locally advanced esophageal squamous cell carcinoma (ESCC) is important, although inter-evaluator heterogeneity (IEH) could exist, especially in borderline resectable (BLR) cases. To investigate the extent of heterogeneity, we conducted clinical diagnostic imaging questionnaires. Materials and methods: Five cases with clinical T3 or T4 cases, which were treated with neo-adjuvant triplet chemotherapy followed by surgery, were selected as the model. These cases were divided into two groups: curative resected cases (#1–#3) and non-curative resected cases (#4 and #5). Only imaging slides were shown without any information about patient characteristics or clinical course. The evaluators consisted of surgeons (staff and non-staff), medical oncologists, and an imaging radiologist; a total of 25 medical staff answered the questionnaire. Two questions (1: clinical T stage before chemotherapy, 2: resectability after chemotherapy) were answered. Occupational differences were assessed by comparing the results to the imaging radiologist. Results: IEH was observed for clinical diagnosis before chemotherapy in one case (clinical T4: 52%, clinical T3: 48%). In the other cases, most evaluators diagnosed them as clinical T4, with 76–88% agreement. IEH for clinical resectability after chemotherapy was relatively small. Occupational IEH was observed in both before and after chemotherapy. Conclusion: IEH in decisions about treating BLR cases in ESCC should be considered in clinical practice. Multi-disciplinary teams are essential to overcome this problem.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalEsophagus
DOIs
Publication statusAccepted/In press - 2017 May 23

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Drug Therapy
Diagnostic Imaging
Medical Staff
Adjuvant Chemotherapy
Esophageal Squamous Cell Carcinoma
Surveys and Questionnaires
Radiologists

Keywords

  • Esophageal cancer
  • Heterogeneity
  • Resectability

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Inter-evaluator heterogeneity of clinical diagnosis for locally advanced esophageal squamous cell carcinoma. / Hamamoto, Yasuo; Nojima, Masanori; Aoki, Yu; Suzuki, Takeshi; Kawasaki, Kenta; Hirata, Kenro; Sukawa, Yasutaka; Kasuga, Akira; Kawakubo, Hirofumi; Takeuchi, Hiroya; Murakami, Koji; Takaishi, Hiromasa; Kanai, Takanori; Kitagawa, Yuukou.

In: Esophagus, 23.05.2017, p. 1-9.

Research output: Contribution to journalArticle

Hamamoto, Yasuo ; Nojima, Masanori ; Aoki, Yu ; Suzuki, Takeshi ; Kawasaki, Kenta ; Hirata, Kenro ; Sukawa, Yasutaka ; Kasuga, Akira ; Kawakubo, Hirofumi ; Takeuchi, Hiroya ; Murakami, Koji ; Takaishi, Hiromasa ; Kanai, Takanori ; Kitagawa, Yuukou. / Inter-evaluator heterogeneity of clinical diagnosis for locally advanced esophageal squamous cell carcinoma. In: Esophagus. 2017 ; pp. 1-9.
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abstract = "Background: Identifying clinical resectability of locally advanced esophageal squamous cell carcinoma (ESCC) is important, although inter-evaluator heterogeneity (IEH) could exist, especially in borderline resectable (BLR) cases. To investigate the extent of heterogeneity, we conducted clinical diagnostic imaging questionnaires. Materials and methods: Five cases with clinical T3 or T4 cases, which were treated with neo-adjuvant triplet chemotherapy followed by surgery, were selected as the model. These cases were divided into two groups: curative resected cases (#1–#3) and non-curative resected cases (#4 and #5). Only imaging slides were shown without any information about patient characteristics or clinical course. The evaluators consisted of surgeons (staff and non-staff), medical oncologists, and an imaging radiologist; a total of 25 medical staff answered the questionnaire. Two questions (1: clinical T stage before chemotherapy, 2: resectability after chemotherapy) were answered. Occupational differences were assessed by comparing the results to the imaging radiologist. Results: IEH was observed for clinical diagnosis before chemotherapy in one case (clinical T4: 52{\%}, clinical T3: 48{\%}). In the other cases, most evaluators diagnosed them as clinical T4, with 76–88{\%} agreement. IEH for clinical resectability after chemotherapy was relatively small. Occupational IEH was observed in both before and after chemotherapy. Conclusion: IEH in decisions about treating BLR cases in ESCC should be considered in clinical practice. Multi-disciplinary teams are essential to overcome this problem.",
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AU - Hamamoto, Yasuo

AU - Nojima, Masanori

AU - Aoki, Yu

AU - Suzuki, Takeshi

AU - Kawasaki, Kenta

AU - Hirata, Kenro

AU - Sukawa, Yasutaka

AU - Kasuga, Akira

AU - Kawakubo, Hirofumi

AU - Takeuchi, Hiroya

AU - Murakami, Koji

AU - Takaishi, Hiromasa

AU - Kanai, Takanori

AU - Kitagawa, Yuukou

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N2 - Background: Identifying clinical resectability of locally advanced esophageal squamous cell carcinoma (ESCC) is important, although inter-evaluator heterogeneity (IEH) could exist, especially in borderline resectable (BLR) cases. To investigate the extent of heterogeneity, we conducted clinical diagnostic imaging questionnaires. Materials and methods: Five cases with clinical T3 or T4 cases, which were treated with neo-adjuvant triplet chemotherapy followed by surgery, were selected as the model. These cases were divided into two groups: curative resected cases (#1–#3) and non-curative resected cases (#4 and #5). Only imaging slides were shown without any information about patient characteristics or clinical course. The evaluators consisted of surgeons (staff and non-staff), medical oncologists, and an imaging radiologist; a total of 25 medical staff answered the questionnaire. Two questions (1: clinical T stage before chemotherapy, 2: resectability after chemotherapy) were answered. Occupational differences were assessed by comparing the results to the imaging radiologist. Results: IEH was observed for clinical diagnosis before chemotherapy in one case (clinical T4: 52%, clinical T3: 48%). In the other cases, most evaluators diagnosed them as clinical T4, with 76–88% agreement. IEH for clinical resectability after chemotherapy was relatively small. Occupational IEH was observed in both before and after chemotherapy. Conclusion: IEH in decisions about treating BLR cases in ESCC should be considered in clinical practice. Multi-disciplinary teams are essential to overcome this problem.

AB - Background: Identifying clinical resectability of locally advanced esophageal squamous cell carcinoma (ESCC) is important, although inter-evaluator heterogeneity (IEH) could exist, especially in borderline resectable (BLR) cases. To investigate the extent of heterogeneity, we conducted clinical diagnostic imaging questionnaires. Materials and methods: Five cases with clinical T3 or T4 cases, which were treated with neo-adjuvant triplet chemotherapy followed by surgery, were selected as the model. These cases were divided into two groups: curative resected cases (#1–#3) and non-curative resected cases (#4 and #5). Only imaging slides were shown without any information about patient characteristics or clinical course. The evaluators consisted of surgeons (staff and non-staff), medical oncologists, and an imaging radiologist; a total of 25 medical staff answered the questionnaire. Two questions (1: clinical T stage before chemotherapy, 2: resectability after chemotherapy) were answered. Occupational differences were assessed by comparing the results to the imaging radiologist. Results: IEH was observed for clinical diagnosis before chemotherapy in one case (clinical T4: 52%, clinical T3: 48%). In the other cases, most evaluators diagnosed them as clinical T4, with 76–88% agreement. IEH for clinical resectability after chemotherapy was relatively small. Occupational IEH was observed in both before and after chemotherapy. Conclusion: IEH in decisions about treating BLR cases in ESCC should be considered in clinical practice. Multi-disciplinary teams are essential to overcome this problem.

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