Inter-organ communication pathway manifested by non-physiological stress to the kidney in type ii diabetic patients -why are diabetic patients prone to develop heart failure?

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It has become clear that sodium glucose cotransporter (SGLT)-2 inhibitors not only do not increase the incidence of cardiovascular events but they also reduce the duration of hospitalization for heart failure in type 2 diabetes mellitus (T2DM) patients. The administration of SGLT2 inhibitor in T2DM patients with hypertension and a fluid retention tendency lowers the blood pressure and mitigates fluid retention. It also reduces the heart rate in T2DM patients with a fast heart rate. As an explanation for the multifaceted effects of SGLT2 inhibitors on hemodynamics, we hypothesize that these agents act on the inter-organ communication pathway, which modulates the sympathetic nerve activity to the cardiovascular system.

Original languageEnglish
JournalInternal Medicine
Issue number1
Publication statusPublished - 2020 Jan 1



  • Erythropoietin
  • Heart failure
  • Hematocrit
  • Inter-organ communication
  • SGLT2 inhibitor

ASJC Scopus subject areas

  • Internal Medicine

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