Interactions between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases among the Japanese population

Tara Sefanya Kairupan, Rie Ibusuki, Motahare Kheradmand, Yasuko Sagara, Eva Mariane Mantjoro, Yora Nindita, Hideshi Niimura, Kazuyo Kuwabara, Shin Ogawa, Noriko Tsumematsu-Nakahata, Yasuhito Nerome, Tetsuhiro Owaki, Toshifumi Matsushita, Shigeho Maenohara, Kazunari Yamaguchi, Toshiro Takezaki

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3 Citations (Scopus)

Abstract

Background: An increased risk of total death owing to human T-lymphotropic virus type-I (HTLV-I) infection has been reported. However, its etiology and protective factors are unclear. Various studies reported fluctuations in immune-inflammatory status among HTLV-I carriers. We conducted a matched cohort study among the general population in an HTLV-I-endemic region of Japan to investigate the interaction between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases. Method: We selected 2180 sub-cohort subjects aged 35-69 years from the cohort population, after matching for age, sex, and region with HTLV-I seropositives. They were followed up for a maximum of 10 years. Inflammatory gene polymorphisms were selected from TNF-α, IL-10, and NF-κB1. A Cox proportional hazard model was used to estimate the hazard ratio (HR) and the interaction between gene polymorphisms and HTLV-I for risk of total death and incidence of cancer and atherosclerosis-related diseases. Results: HTLV-I seropositivity rate was 6.4% in the cohort population. The interaction between TNF-a 1031T/C and HTLV-I for atherosclerosis-related disease incidence was statistically significant (p = 0.020). No significant interaction was observed between IL-10 819T/C or NF-κB1 94ATTG ins/del and HTLV-I. An increased HR for total death was observed in the Amami island region, after adjustment of various factors with gene polymorphisms (HR 3.03; 95% confidence interval, 1.18-7.77). Conclusion: The present study found the interaction between TNF-α 1031T/C and HTLV-I to be a risk factor for atherosclerosis-related disease. Further follow-up is warranted to investigate protective factors against developing diseases among susceptible HTLV-I carriers.

Original languageEnglish
Pages (from-to)420-427
Number of pages8
JournalJournal of epidemiology
Volume27
Issue number9
DOIs
Publication statusPublished - 2017

Keywords

  • Gene polymorphism
  • HTLV-I
  • Inflammation
  • Interaction

ASJC Scopus subject areas

  • Epidemiology

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    Kairupan, T. S., Ibusuki, R., Kheradmand, M., Sagara, Y., Mantjoro, E. M., Nindita, Y., Niimura, H., Kuwabara, K., Ogawa, S., Tsumematsu-Nakahata, N., Nerome, Y., Owaki, T., Matsushita, T., Maenohara, S., Yamaguchi, K., & Takezaki, T. (2017). Interactions between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases among the Japanese population. Journal of epidemiology, 27(9), 420-427. https://doi.org/10.1016/j.je.2016.08.017