Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses

Kazuyo Moro, Hiroki Kabata, Masanobu Tanabe, Satoshi Koga, Natsuki Takeno, Miho Mochizuki, Koichi Fukunaga, Koichiro Asano, Tomoko Betsuyaku, Shigeo Koyasu

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182 Citations (Scopus)

Abstract

Group 2 innate lymphoid cells (ILC2 cells) are type 2 cytokine-producing cells of the innate immune system with important roles in helminth infection and allergic inflammation. Here we found that tissue-resident ILC2 cells proliferated in situ without migrating during inflammatory responses. Both type I and type II interferons and interleukin 27 (IL-27) suppressed ILC2 function in a manner dependent on the transcription factor STAT1. ILC2-mediated lung inflammation was enhanced in the absence of the interferon-γ (IFN-γ) receptor on ILC2 cells in vivo. IFN-γ effectively suppressed the function of tissue-resident ILC2 cells but not that of inflammatory ILC2 cells, and IL-27 suppressed tissue-resident ILC2 cells but not tissue-resident T H 2 cells during lung inflammation induced by Alternaria alternata. Our results demonstrate that suppression mediated by interferon and IL-27 is a negative feedback mechanism for ILC2 function in vivo.

Original languageEnglish
Pages (from-to)76-86
Number of pages11
JournalNature Immunology
Volume17
Issue number1
DOIs
Publication statusPublished - 2016 Jan 1

ASJC Scopus subject areas

  • Immunology

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    Moro, K., Kabata, H., Tanabe, M., Koga, S., Takeno, N., Mochizuki, M., Fukunaga, K., Asano, K., Betsuyaku, T., & Koyasu, S. (2016). Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses. Nature Immunology, 17(1), 76-86. https://doi.org/10.1038/ni.3309