Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses

Kazuyo Moro, Hiroki Kabata, Masanobu Tanabe, Satoshi Koga, Natsuki Takeno, Miho Mochizuki, Koichi Fukunaga, Koichiro Asano, Tomoko Betsuyaku, Shigeo Koyasu

Research output: Contribution to journalArticle

164 Citations (Scopus)

Abstract

Group 2 innate lymphoid cells (ILC2 cells) are type 2 cytokine-producing cells of the innate immune system with important roles in helminth infection and allergic inflammation. Here we found that tissue-resident ILC2 cells proliferated in situ without migrating during inflammatory responses. Both type I and type II interferons and interleukin 27 (IL-27) suppressed ILC2 function in a manner dependent on the transcription factor STAT1. ILC2-mediated lung inflammation was enhanced in the absence of the interferon-γ (IFN-γ) receptor on ILC2 cells in vivo. IFN-γ effectively suppressed the function of tissue-resident ILC2 cells but not that of inflammatory ILC2 cells, and IL-27 suppressed tissue-resident ILC2 cells but not tissue-resident T H 2 cells during lung inflammation induced by Alternaria alternata. Our results demonstrate that suppression mediated by interferon and IL-27 is a negative feedback mechanism for ILC2 function in vivo.

Original languageEnglish
Pages (from-to)76-86
Number of pages11
JournalNature Immunology
Volume17
Issue number1
DOIs
Publication statusPublished - 2016 Jan 1

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Interleukin-27
Innate Immunity
Interferons
Lymphocytes
Pneumonia
Interferon Receptors
STAT1 Transcription Factor
Alternaria
Interferon Type I
Helminths
Interferon-gamma
Immune System
Cytokines
Inflammation

ASJC Scopus subject areas

  • Immunology

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Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses. / Moro, Kazuyo; Kabata, Hiroki; Tanabe, Masanobu; Koga, Satoshi; Takeno, Natsuki; Mochizuki, Miho; Fukunaga, Koichi; Asano, Koichiro; Betsuyaku, Tomoko; Koyasu, Shigeo.

In: Nature Immunology, Vol. 17, No. 1, 01.01.2016, p. 76-86.

Research output: Contribution to journalArticle

Moro, K, Kabata, H, Tanabe, M, Koga, S, Takeno, N, Mochizuki, M, Fukunaga, K, Asano, K, Betsuyaku, T & Koyasu, S 2016, 'Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses', Nature Immunology, vol. 17, no. 1, pp. 76-86. https://doi.org/10.1038/ni.3309
Moro, Kazuyo ; Kabata, Hiroki ; Tanabe, Masanobu ; Koga, Satoshi ; Takeno, Natsuki ; Mochizuki, Miho ; Fukunaga, Koichi ; Asano, Koichiro ; Betsuyaku, Tomoko ; Koyasu, Shigeo. / Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses. In: Nature Immunology. 2016 ; Vol. 17, No. 1. pp. 76-86.
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