Abstract
Various cytokines, including interferon (IFN)-γ and IL-17, are augmented, and autoreactive T cells and B cells are activated in the immune pathogenesis of Sjögren's syndrome (SS). In particular, IFNs are involved in both the early stages of innate immunity by high level of type I IFN in glandular tissue and sera and the later stages of disease progression by type I and type II IFN producing T cells and B cells through B cell activating factor in SS. Genetically modified mouse models for some of these molecules have been reported and will be discussed in this review. New findings from human SS and animal models of SS have elucidated some of the mechanisms underlying SS-related dry eye. We will discuss IFN-γ and several other molecules that represent candidate targets for treating inflammation in SS-related dry eye.
| Original language | English |
|---|---|
| Journal | International Journal of Molecular Sciences |
| Volume | 19 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2018 Nov 10 |
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Keywords
- animal model
- dry eye
- Interferon-γ
- Sjögren’s syndrome
ASJC Scopus subject areas
- Catalysis
- Molecular Biology
- Spectroscopy
- Computer Science Applications
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry
Cite this
Interferons and Dry Eye in Sjögren's Syndrome. / Ogawa, Yoko; Shimizu, Eisuke; Tsubota, Kazuo.
In: International Journal of Molecular Sciences, Vol. 19, No. 11, 10.11.2018.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Interferons and Dry Eye in Sjögren's Syndrome
AU - Ogawa, Yoko
AU - Shimizu, Eisuke
AU - Tsubota, Kazuo
PY - 2018/11/10
Y1 - 2018/11/10
N2 - Various cytokines, including interferon (IFN)-γ and IL-17, are augmented, and autoreactive T cells and B cells are activated in the immune pathogenesis of Sjögren's syndrome (SS). In particular, IFNs are involved in both the early stages of innate immunity by high level of type I IFN in glandular tissue and sera and the later stages of disease progression by type I and type II IFN producing T cells and B cells through B cell activating factor in SS. Genetically modified mouse models for some of these molecules have been reported and will be discussed in this review. New findings from human SS and animal models of SS have elucidated some of the mechanisms underlying SS-related dry eye. We will discuss IFN-γ and several other molecules that represent candidate targets for treating inflammation in SS-related dry eye.
AB - Various cytokines, including interferon (IFN)-γ and IL-17, are augmented, and autoreactive T cells and B cells are activated in the immune pathogenesis of Sjögren's syndrome (SS). In particular, IFNs are involved in both the early stages of innate immunity by high level of type I IFN in glandular tissue and sera and the later stages of disease progression by type I and type II IFN producing T cells and B cells through B cell activating factor in SS. Genetically modified mouse models for some of these molecules have been reported and will be discussed in this review. New findings from human SS and animal models of SS have elucidated some of the mechanisms underlying SS-related dry eye. We will discuss IFN-γ and several other molecules that represent candidate targets for treating inflammation in SS-related dry eye.
KW - animal model
KW - dry eye
KW - Interferon-γ
KW - Sjögren’s syndrome
UR - http://www.scopus.com/inward/record.url?scp=85056538624&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85056538624&partnerID=8YFLogxK
U2 - 10.3390/ijms19113548
DO - 10.3390/ijms19113548
M3 - Review article
C2 - 30423813
AN - SCOPUS:85056538624
VL - 19
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 11
ER -