Interindividual Variation of Maximal Blood Levels of Tacrolimus After Its Oral Administration in Hematopoietic Cell Transplant Recipients

Rie Yamazaki, Takehiko Mori, Y. Aisa, Jun Kato, Y. Nakamura, T. Nakazato, A. Mihara, Y. Ikeda, Shinichiro Okamoto

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Abstract

We investigated the pharmacokinetics of oral tacrolimus in 31 hematopoietic cell transplant recipients, identifying 2 subgroups based on the differences between C0 (trough) and Cmax (maximal) levels: group A (n = 21; 68%) with a Cmax-C0 value of <10 ng/mL, and group B (n = 10; 32%) with a Cmax-C0 value of ≥10 ng/mL. Although the C0 and C12 values were not significantly different between the 2 groups, the mean area under the concentration curve for 12 hours (AUC0-12) was significantly greater in group B than group A (200.9 ± 36.3 vs 155.1 ± 43.1 ng · h/mL; P < .05), and the mean half-life was significantly shorter in group B than group A (13.55 ± 6.70 vs 18.17 ± 6.30 hours; P < .05). Thus after the oral administration of tacrolimus, we observed a notably high AUC due to high peak level, which we were unable to predict simply by measuring the trough level. A pharmacokinetic analysis of each patient was essential to optimize the oral tacrolimus dose.

Original languageEnglish
Pages (from-to)1831-1833
Number of pages3
JournalTransplantation Proceedings
Volume41
Issue number5
DOIs
Publication statusPublished - 2009 Jun

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Tacrolimus
Oral Administration
Transplants
Area Under Curve
Pharmacokinetics
Half-Life
Transplant Recipients

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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Interindividual Variation of Maximal Blood Levels of Tacrolimus After Its Oral Administration in Hematopoietic Cell Transplant Recipients. / Yamazaki, Rie; Mori, Takehiko; Aisa, Y.; Kato, Jun; Nakamura, Y.; Nakazato, T.; Mihara, A.; Ikeda, Y.; Okamoto, Shinichiro.

In: Transplantation Proceedings, Vol. 41, No. 5, 06.2009, p. 1831-1833.

Research output: Contribution to journalArticle

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AU - Kato, Jun

AU - Nakamura, Y.

AU - Nakazato, T.

AU - Mihara, A.

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AU - Okamoto, Shinichiro

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