Interleukin-1β and tumor necrosis factor-α co-operatively enhance a novel trophic activity of astrocytes for pontine cholinergic neurons in vitro

Hiroyuki Kamiguchi, Kazunari Yoshida, Makoto Inaba, Hikaru Sasaki, Mitsuhiro Otani, Shigeo Toya

Research output: Contribution to journalArticle

3 Citations (Scopus)


Insulin and insulin-like growth factors (IGFs)) are the only known trophic factors for pontine cholinergic neurons. The present study revealed that astrocyte-extract pretreated with IL-1β and TNF-α significantly enhanced choline acetyltransferase (ChAT) activity of the pontine neurons in the presence of a supramaximal dose of insulin, while various trophic factors including IGFs failed to increase the ChAT activity under the same culture conditions, suggesting that IL-1β and TNF-α co-operatively enhanced the expression of a novel trophic factor for pontine cholinergic neurons in astrocytes.

Original languageEnglish
Pages (from-to)43-47
Number of pages5
JournalRestorative Neurology and Neuroscience
Issue number1
Publication statusPublished - 1996 Jul 1



  • Astrocyte
  • Choline acetyltransferase
  • Interleukin-1β
  • Neurotrophic efect
  • Pontine cholinergic neuron
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

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