Interleukin-1β and tumor necrosis factor-α co-operatively enhance a novel trophic activity of astrocytes for pontine cholinergic neurons in vitro

Hiroyuki Kamiguchi; Kazunari Yoshida; Makoto Inaba; Hikaru Sasaki; Mitsuhiro Otani; Shigeo Toya

doi:10.3233/rnn-1996-10106

Interleukin-1β and tumor necrosis factor-α co-operatively enhance a novel trophic activity of astrocytes for pontine cholinergic neurons in vitro

Hiroyuki Kamiguchi, Kazunari Yoshida, Makoto Inaba, Hikaru Sasaki, Mitsuhiro Otani, Shigeo Toya

Department of Neurosurgery

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Insulin and insulin-like growth factors (IGFs)) are the only known trophic factors for pontine cholinergic neurons. The present study revealed that astrocyte-extract pretreated with IL-1β and TNF-α significantly enhanced choline acetyltransferase (ChAT) activity of the pontine neurons in the presence of a supramaximal dose of insulin, while various trophic factors including IGFs failed to increase the ChAT activity under the same culture conditions, suggesting that IL-1β and TNF-α co-operatively enhanced the expression of a novel trophic factor for pontine cholinergic neurons in astrocytes.

Original language	English
Pages (from-to)	43-47
Number of pages	5
Journal	Restorative Neurology and Neuroscience
Volume	10
Issue number	1
DOIs	https://doi.org/10.3233/rnn-1996-10106
Publication status	Published - 1996 Jul

Keywords

Astrocyte
Choline acetyltransferase
Interleukin-1β
Neurotrophic efect
Pontine cholinergic neuron
Tumor necrosis factor-α

ASJC Scopus subject areas

Neurology
Developmental Neuroscience
Clinical Neurology

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10.3233/rnn-1996-10106

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Interleukin-1β and tumor necrosis factor-α co-operatively enhance a novel trophic activity of astrocytes for pontine cholinergic neurons in vitro. / Kamiguchi, Hiroyuki; Yoshida, Kazunari; Inaba, Makoto; Sasaki, Hikaru; Otani, Mitsuhiro; Toya, Shigeo.

In: Restorative Neurology and Neuroscience, Vol. 10, No. 1, 07.1996, p. 43-47.

Research output: Contribution to journal › Article › peer-review

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