Abstract
Insulin and insulin-like growth factors (IGFs)) are the only known trophic factors for pontine cholinergic neurons. The present study revealed that astrocyte-extract pretreated with IL-1β and TNF-α significantly enhanced choline acetyltransferase (ChAT) activity of the pontine neurons in the presence of a supramaximal dose of insulin, while various trophic factors including IGFs failed to increase the ChAT activity under the same culture conditions, suggesting that IL-1β and TNF-α co-operatively enhanced the expression of a novel trophic factor for pontine cholinergic neurons in astrocytes.
| Original language | English |
|---|---|
| Pages (from-to) | 43-47 |
| Number of pages | 5 |
| Journal | Restorative Neurology and Neuroscience |
| Volume | 10 |
| Issue number | 1 |
| Publication status | Published - 1996 Jul |
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Keywords
- Astrocyte
- Choline acetyltransferase
- Interleukin-1β
- Neurotrophic efect
- Pontine cholinergic neuron
- Tumor necrosis factor-α
ASJC Scopus subject areas
- Neuroscience(all)
- Neuropsychology and Physiological Psychology
Cite this
Interleukin-1β and tumor necrosis factor-α co-operatively enhance a novel trophic activity of astrocytes for pontine cholinergic neurons in vitro. / Kamiguchi, Hiroyuki; Yoshida, Kazunari; Inaba, Makoto; Sasaki, Hikaru; Otani, Mitsuhiro; Toya, Shigeo.
In: Restorative Neurology and Neuroscience, Vol. 10, No. 1, 07.1996, p. 43-47.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interleukin-1β and tumor necrosis factor-α co-operatively enhance a novel trophic activity of astrocytes for pontine cholinergic neurons in vitro
AU - Kamiguchi, Hiroyuki
AU - Yoshida, Kazunari
AU - Inaba, Makoto
AU - Sasaki, Hikaru
AU - Otani, Mitsuhiro
AU - Toya, Shigeo
PY - 1996/7
Y1 - 1996/7
N2 - Insulin and insulin-like growth factors (IGFs)) are the only known trophic factors for pontine cholinergic neurons. The present study revealed that astrocyte-extract pretreated with IL-1β and TNF-α significantly enhanced choline acetyltransferase (ChAT) activity of the pontine neurons in the presence of a supramaximal dose of insulin, while various trophic factors including IGFs failed to increase the ChAT activity under the same culture conditions, suggesting that IL-1β and TNF-α co-operatively enhanced the expression of a novel trophic factor for pontine cholinergic neurons in astrocytes.
AB - Insulin and insulin-like growth factors (IGFs)) are the only known trophic factors for pontine cholinergic neurons. The present study revealed that astrocyte-extract pretreated with IL-1β and TNF-α significantly enhanced choline acetyltransferase (ChAT) activity of the pontine neurons in the presence of a supramaximal dose of insulin, while various trophic factors including IGFs failed to increase the ChAT activity under the same culture conditions, suggesting that IL-1β and TNF-α co-operatively enhanced the expression of a novel trophic factor for pontine cholinergic neurons in astrocytes.
KW - Astrocyte
KW - Choline acetyltransferase
KW - Interleukin-1β
KW - Neurotrophic efect
KW - Pontine cholinergic neuron
KW - Tumor necrosis factor-α
UR - http://www.scopus.com/inward/record.url?scp=0029955842&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029955842&partnerID=8YFLogxK
M3 - Article
C2 - 21551852
AN - SCOPUS:0029955842
VL - 10
SP - 43
EP - 47
JO - Restorative Neurology and Neuroscience
JF - Restorative Neurology and Neuroscience
SN - 0922-6028
IS - 1
ER -