Interleukin-1β and tumor necrosis factor-α co-operatively enhance a novel trophic activity of astrocytes for pontine cholinergic neurons in vitro

Hiroyuki Kamiguchi, Kazunari Yoshida, Makoto Inaba, Hikaru Sasaki, Mitsuhiro Otani, Shigeo Toya

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Insulin and insulin-like growth factors (IGFs)) are the only known trophic factors for pontine cholinergic neurons. The present study revealed that astrocyte-extract pretreated with IL-1β and TNF-α significantly enhanced choline acetyltransferase (ChAT) activity of the pontine neurons in the presence of a supramaximal dose of insulin, while various trophic factors including IGFs failed to increase the ChAT activity under the same culture conditions, suggesting that IL-1β and TNF-α co-operatively enhanced the expression of a novel trophic factor for pontine cholinergic neurons in astrocytes.

Original languageEnglish
Pages (from-to)43-47
Number of pages5
JournalRestorative Neurology and Neuroscience
Volume10
Issue number1
Publication statusPublished - 1996 Jul

Fingerprint

Cholinergic Neurons
Choline O-Acetyltransferase
Somatomedins
Interleukin-1
Astrocytes
Tumor Necrosis Factor-alpha
Insulin
Neurons
In Vitro Techniques

Keywords

  • Astrocyte
  • Choline acetyltransferase
  • Interleukin-1β
  • Neurotrophic efect
  • Pontine cholinergic neuron
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Interleukin-1β and tumor necrosis factor-α co-operatively enhance a novel trophic activity of astrocytes for pontine cholinergic neurons in vitro. / Kamiguchi, Hiroyuki; Yoshida, Kazunari; Inaba, Makoto; Sasaki, Hikaru; Otani, Mitsuhiro; Toya, Shigeo.

In: Restorative Neurology and Neuroscience, Vol. 10, No. 1, 07.1996, p. 43-47.

Research output: Contribution to journalArticle

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AU - Otani, Mitsuhiro

AU - Toya, Shigeo

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