Abstract
Insulin and insulin-like growth factors (IGFs)) are the only known trophic factors for pontine cholinergic neurons. The present study revealed that astrocyte-extract pretreated with IL-1β and TNF-α significantly enhanced choline acetyltransferase (ChAT) activity of the pontine neurons in the presence of a supramaximal dose of insulin, while various trophic factors including IGFs failed to increase the ChAT activity under the same culture conditions, suggesting that IL-1β and TNF-α co-operatively enhanced the expression of a novel trophic factor for pontine cholinergic neurons in astrocytes.
| Original language | English |
|---|---|
| Pages (from-to) | 43-47 |
| Number of pages | 5 |
| Journal | Restorative Neurology and Neuroscience |
| Volume | 10 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1996 Jul |
Keywords
- Astrocyte
- Choline acetyltransferase
- Interleukin-1β
- Neurotrophic efect
- Pontine cholinergic neuron
- Tumor necrosis factor-α
ASJC Scopus subject areas
- Neurology
- Developmental Neuroscience
- Clinical Neurology
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Cite this
Kamiguchi, H., Yoshida, K., Inaba, M., Sasaki, H., Otani, M., & Toya, S. (1996). Interleukin-1β and tumor necrosis factor-α co-operatively enhance a novel trophic activity of astrocytes for pontine cholinergic neurons in vitro. Restorative Neurology and Neuroscience, 10(1), 43-47. https://doi.org/10.3233/rnn-1996-10106