Interleukin-18 and Crohn's disease

Takanori Kanai; Mamoru Watanabe; Akira Okazawa; Toshiro Sato; Toshifumi Hibi

doi:10.1159/000051909

Interleukin-18 and Crohn's disease

Takanori Kanai, Mamoru Watanabe, Akira Okazawa, Toshiro Sato, Toshifumi Hibi

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

The etiology and pathogenesis of inflammatory bowel disease remains an area under intense investigation. Crohn's disease (CD) is characterized by a marked accumulation of activated Th1 type CD4+ T cells and macrophages in inflamed intestinal mucosa. IL-18 is a recently described cytokine that mainly exists in activated macrophages and shares biological activities with IL-12 in driving the development of Th1 type CD4+ T cells by inducing interferon-γ. To clarify the role of IL-18 in intestinal inflammation in CD, we assessed the functional role of IL-18 in regulating intestinal mucosal lymphocytes in human CD and murine CD model.

Original language	English
Pages (from-to)	37-42
Number of pages	6
Journal	Digestion
Volume	63
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1159/000051909
Publication status	Published - 2001 Feb 6

Keywords

Crohn's disease
Interleukin-18
Proinflammatory cytokine
Th1

ASJC Scopus subject areas

Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000051909

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AU - Kanai, Takanori

AU - Watanabe, Mamoru

AU - Okazawa, Akira

AU - Sato, Toshiro

AU - Hibi, Toshifumi

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N2 - The etiology and pathogenesis of inflammatory bowel disease remains an area under intense investigation. Crohn's disease (CD) is characterized by a marked accumulation of activated Th1 type CD4+ T cells and macrophages in inflamed intestinal mucosa. IL-18 is a recently described cytokine that mainly exists in activated macrophages and shares biological activities with IL-12 in driving the development of Th1 type CD4+ T cells by inducing interferon-γ. To clarify the role of IL-18 in intestinal inflammation in CD, we assessed the functional role of IL-18 in regulating intestinal mucosal lymphocytes in human CD and murine CD model.

AB - The etiology and pathogenesis of inflammatory bowel disease remains an area under intense investigation. Crohn's disease (CD) is characterized by a marked accumulation of activated Th1 type CD4+ T cells and macrophages in inflamed intestinal mucosa. IL-18 is a recently described cytokine that mainly exists in activated macrophages and shares biological activities with IL-12 in driving the development of Th1 type CD4+ T cells by inducing interferon-γ. To clarify the role of IL-18 in intestinal inflammation in CD, we assessed the functional role of IL-18 in regulating intestinal mucosal lymphocytes in human CD and murine CD model.

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KW - Proinflammatory cytokine

KW - Th1

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Interleukin-18 and Crohn's disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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