Abstract
The etiology and pathogenesis of inflammatory bowel disease remains an area under intense investigation. Crohn's disease (CD) is characterized by a marked accumulation of activated Th1 type CD4+ T cells and macrophages in inflamed intestinal mucosa. IL-18 is a recently described cytokine that mainly exists in activated macrophages and shares biological activities with IL-12 in driving the development of Th1 type CD4+ T cells by inducing interferon-γ. To clarify the role of IL-18 in intestinal inflammation in CD, we assessed the functional role of IL-18 in regulating intestinal mucosal lymphocytes in human CD and murine CD model.
| Original language | English |
|---|---|
| Pages (from-to) | 37-42 |
| Number of pages | 6 |
| Journal | Digestion |
| Volume | 63 |
| Issue number | SUPPL. 1 |
| DOIs | |
| Publication status | Published - 2001 |
Fingerprint
Keywords
- Crohn's disease
- Interleukin-18
- Proinflammatory cytokine
- Th1
ASJC Scopus subject areas
- Gastroenterology
Cite this
Interleukin-18 and Crohn's disease. / Kanai, Takanori; Watanabe, Mamoru; Okazawa, Akira; Sato, Toshiro; Hibi, Toshifumi.
In: Digestion, Vol. 63, No. SUPPL. 1, 2001, p. 37-42.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interleukin-18 and Crohn's disease
AU - Kanai, Takanori
AU - Watanabe, Mamoru
AU - Okazawa, Akira
AU - Sato, Toshiro
AU - Hibi, Toshifumi
PY - 2001
Y1 - 2001
N2 - The etiology and pathogenesis of inflammatory bowel disease remains an area under intense investigation. Crohn's disease (CD) is characterized by a marked accumulation of activated Th1 type CD4+ T cells and macrophages in inflamed intestinal mucosa. IL-18 is a recently described cytokine that mainly exists in activated macrophages and shares biological activities with IL-12 in driving the development of Th1 type CD4+ T cells by inducing interferon-γ. To clarify the role of IL-18 in intestinal inflammation in CD, we assessed the functional role of IL-18 in regulating intestinal mucosal lymphocytes in human CD and murine CD model.
AB - The etiology and pathogenesis of inflammatory bowel disease remains an area under intense investigation. Crohn's disease (CD) is characterized by a marked accumulation of activated Th1 type CD4+ T cells and macrophages in inflamed intestinal mucosa. IL-18 is a recently described cytokine that mainly exists in activated macrophages and shares biological activities with IL-12 in driving the development of Th1 type CD4+ T cells by inducing interferon-γ. To clarify the role of IL-18 in intestinal inflammation in CD, we assessed the functional role of IL-18 in regulating intestinal mucosal lymphocytes in human CD and murine CD model.
KW - Crohn's disease
KW - Interleukin-18
KW - Proinflammatory cytokine
KW - Th1
UR - http://www.scopus.com/inward/record.url?scp=0035137669&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035137669&partnerID=8YFLogxK
U2 - 10.1159/000051909
DO - 10.1159/000051909
M3 - Article
C2 - 11173908
AN - SCOPUS:0035137669
VL - 63
SP - 37
EP - 42
JO - Digestion
JF - Digestion
SN - 0012-2823
IS - SUPPL. 1
ER -