Abstract
The etiology and pathogenesis of inflammatory bowel disease remains an area under intense investigation. Crohn's disease (CD) is characterized by a marked accumulation of activated Th1 type CD4+ T cells and macrophages in inflamed intestinal mucosa. IL-18 is a recently described cytokine that mainly exists in activated macrophages and shares biological activities with IL-12 in driving the development of Th1 type CD4+ T cells by inducing interferon-γ. To clarify the role of IL-18 in intestinal inflammation in CD, we assessed the functional role of IL-18 in regulating intestinal mucosal lymphocytes in human CD and murine CD model.
Original language | English |
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Pages (from-to) | 37-42 |
Number of pages | 6 |
Journal | Digestion |
Volume | 63 |
Issue number | SUPPL. 1 |
DOIs | |
Publication status | Published - 2001 Feb 6 |
Keywords
- Crohn's disease
- Interleukin-18
- Proinflammatory cytokine
- Th1
ASJC Scopus subject areas
- Gastroenterology