Interleukin-18 and Crohn's disease

Takanori Kanai, Mamoru Watanabe, Akira Okazawa, Toshiro Sato, Toshifumi Hibi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The etiology and pathogenesis of inflammatory bowel disease remains an area under intense investigation. Crohn's disease (CD) is characterized by a marked accumulation of activated Th1 type CD4+ T cells and macrophages in inflamed intestinal mucosa. IL-18 is a recently described cytokine that mainly exists in activated macrophages and shares biological activities with IL-12 in driving the development of Th1 type CD4+ T cells by inducing interferon-γ. To clarify the role of IL-18 in intestinal inflammation in CD, we assessed the functional role of IL-18 in regulating intestinal mucosal lymphocytes in human CD and murine CD model.

Original languageEnglish
Pages (from-to)37-42
Number of pages6
JournalDigestion
Volume63
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 2001 Feb 6

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Keywords

  • Crohn's disease
  • Interleukin-18
  • Proinflammatory cytokine
  • Th1

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Kanai, T., Watanabe, M., Okazawa, A., Sato, T., & Hibi, T. (2001). Interleukin-18 and Crohn's disease. Digestion, 63(SUPPL. 1), 37-42. https://doi.org/10.1159/000051909