Interleukin-18 and Crohn's disease

Takanori Kanai, Mamoru Watanabe, Akira Okazawa, Toshiro Sato, Toshifumi Hibi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The etiology and pathogenesis of inflammatory bowel disease remains an area under intense investigation. Crohn's disease (CD) is characterized by a marked accumulation of activated Th1 type CD4+ T cells and macrophages in inflamed intestinal mucosa. IL-18 is a recently described cytokine that mainly exists in activated macrophages and shares biological activities with IL-12 in driving the development of Th1 type CD4+ T cells by inducing interferon-γ. To clarify the role of IL-18 in intestinal inflammation in CD, we assessed the functional role of IL-18 in regulating intestinal mucosal lymphocytes in human CD and murine CD model.

Original languageEnglish
Pages (from-to)37-42
Number of pages6
JournalDigestion
Volume63
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 2001

Fingerprint

Interleukin-18
Crohn Disease
Macrophages
T-Lymphocytes
Intestinal Mucosa
Interleukin-12
Inflammatory Bowel Diseases
Interferons
Lymphocytes
Cytokines
Inflammation

Keywords

  • Crohn's disease
  • Interleukin-18
  • Proinflammatory cytokine
  • Th1

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Kanai, T., Watanabe, M., Okazawa, A., Sato, T., & Hibi, T. (2001). Interleukin-18 and Crohn's disease. Digestion, 63(SUPPL. 1), 37-42. https://doi.org/10.1159/000051909

Interleukin-18 and Crohn's disease. / Kanai, Takanori; Watanabe, Mamoru; Okazawa, Akira; Sato, Toshiro; Hibi, Toshifumi.

In: Digestion, Vol. 63, No. SUPPL. 1, 2001, p. 37-42.

Research output: Contribution to journalArticle

Kanai, T, Watanabe, M, Okazawa, A, Sato, T & Hibi, T 2001, 'Interleukin-18 and Crohn's disease', Digestion, vol. 63, no. SUPPL. 1, pp. 37-42. https://doi.org/10.1159/000051909
Kanai T, Watanabe M, Okazawa A, Sato T, Hibi T. Interleukin-18 and Crohn's disease. Digestion. 2001;63(SUPPL. 1):37-42. https://doi.org/10.1159/000051909
Kanai, Takanori ; Watanabe, Mamoru ; Okazawa, Akira ; Sato, Toshiro ; Hibi, Toshifumi. / Interleukin-18 and Crohn's disease. In: Digestion. 2001 ; Vol. 63, No. SUPPL. 1. pp. 37-42.
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