Abstract
The etiology and pathogenesis of inflammatory bowel disease remains an area under intense investigation. Crohn's disease (CD) is characterized by a marked accumulation of activated Th1 type CD4+ T cells and macrophages in inflamed intestinal mucosa. IL-18 is a recently described cytokine that mainly exists in activated macrophages and shares biological activities with IL-12 in driving the development of Th1 type CD4+ T cells by inducing interferon-γ. To clarify the role of IL-18 in intestinal inflammation in CD, we assessed the functional role of IL-18 in regulating intestinal mucosal lymphocytes in human CD and murine CD model.
| Original language | English |
|---|---|
| Pages (from-to) | 37-42 |
| Number of pages | 6 |
| Journal | Digestion |
| Volume | 63 |
| Issue number | SUPPL. 1 |
| DOIs | |
| Publication status | Published - 2001 Feb 6 |
Keywords
- Crohn's disease
- Interleukin-18
- Proinflammatory cytokine
- Th1
ASJC Scopus subject areas
- Gastroenterology
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Cite this
Kanai, T., Watanabe, M., Okazawa, A., Sato, T., & Hibi, T. (2001). Interleukin-18 and Crohn's disease. Digestion, 63(SUPPL. 1), 37-42. https://doi.org/10.1159/000051909