Interleukin 6 Is Associated with Cachexia in Patients with Prostate Cancer

Kenji Kuroda, Jun Nakashima, Kent Kanao, Eiji Kikuchi, Akira Miyajima, Yutaka Horiguchi, Ken Nakagawa, Mototsugu Oya, Takashi Ohigashi, Masaru Murai

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Abstract

Objectives: To evaluate the relationship between serum interleukin (IL)-6 and cachexia in patients with prostate cancer. Methods: Serum levels of IL-6, total protein, albumin, total cholesterol, and hemoglobin concentration were determined in 164 blood samples from patients with prostate cancer. The body mass index and performance status were also determined. Results: The serum total protein, albumin, and cholesterol levels, hemoglobin levels, and body mass index of the patients whose serum IL-6 level was 7 pg/mL or greater were significantly lower (P <0.05) than the corresponding values in patients with a serum IL-6 level of less than 7 pg/mL. The serum IL-6 level of patients with a serum albumin level of less than 3.5 g/dL, serum total protein level of less than 7.0 g/dL, serum total cholesterol level of less than 180 mg/dL, hemoglobin level of less than 11.0 g/dL, and body mass index of less than 21 kg/m2 were significantly greater (P <0.05) than the values in their respective counterparts. A significant correlation was found between the elevation of serum IL-6 and performance status (P <0.05). The mortality rate of patients with greater serum IL-6 levels was significantly greater than that of those with lower serum IL-6 levels in patients with untreated disease, patients in remission, and patients with relapse (all P <0.05). Conclusions: These findings suggest that IL-6 may be one of the factors contributing to the complex syndrome of cachexia in patients with prostate cancer (all P <0.05).

Original languageEnglish
Pages (from-to)113-117
Number of pages5
JournalUrology
Volume69
Issue number1
DOIs
Publication statusPublished - 2007 Jan

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Cachexia
Interleukin-6
Prostatic Neoplasms
Serum
Hemoglobins
Body Mass Index
Cholesterol
Blood Proteins
Albumins
Serum Albumin
Recurrence

ASJC Scopus subject areas

  • Urology

Cite this

Kuroda, K., Nakashima, J., Kanao, K., Kikuchi, E., Miyajima, A., Horiguchi, Y., ... Murai, M. (2007). Interleukin 6 Is Associated with Cachexia in Patients with Prostate Cancer. Urology, 69(1), 113-117. https://doi.org/10.1016/j.urology.2006.09.039

Interleukin 6 Is Associated with Cachexia in Patients with Prostate Cancer. / Kuroda, Kenji; Nakashima, Jun; Kanao, Kent; Kikuchi, Eiji; Miyajima, Akira; Horiguchi, Yutaka; Nakagawa, Ken; Oya, Mototsugu; Ohigashi, Takashi; Murai, Masaru.

In: Urology, Vol. 69, No. 1, 01.2007, p. 113-117.

Research output: Contribution to journalArticle

Kuroda, K, Nakashima, J, Kanao, K, Kikuchi, E, Miyajima, A, Horiguchi, Y, Nakagawa, K, Oya, M, Ohigashi, T & Murai, M 2007, 'Interleukin 6 Is Associated with Cachexia in Patients with Prostate Cancer', Urology, vol. 69, no. 1, pp. 113-117. https://doi.org/10.1016/j.urology.2006.09.039
Kuroda K, Nakashima J, Kanao K, Kikuchi E, Miyajima A, Horiguchi Y et al. Interleukin 6 Is Associated with Cachexia in Patients with Prostate Cancer. Urology. 2007 Jan;69(1):113-117. https://doi.org/10.1016/j.urology.2006.09.039
Kuroda, Kenji ; Nakashima, Jun ; Kanao, Kent ; Kikuchi, Eiji ; Miyajima, Akira ; Horiguchi, Yutaka ; Nakagawa, Ken ; Oya, Mototsugu ; Ohigashi, Takashi ; Murai, Masaru. / Interleukin 6 Is Associated with Cachexia in Patients with Prostate Cancer. In: Urology. 2007 ; Vol. 69, No. 1. pp. 113-117.
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