Abstract
Background: To assess the locoregional control, survival and toxicities of combined intermediate-dose preoperative irradiation and surgery for rectal cancer patients. Materials and Methods: Forty-two patients with adenocarcinoma of the rectum underwent intermediate-dose pre-operative radiotherapy. The median age was 58 years, the prescribed dose was 30.6 Gy to the whole pelvis, while a boost of 4x3 Gy to the primary tumor was added. The calculated linear-quadratic dose was 52 Gy. Results: Failure as a first site was pelvic in 2 and distant in 11. The crude pelvic failure rate was 9.5%. The 3- and 5-year overall survival was 75% and 63%, respectively. Pre-operative radiotherapy was well-tolerated by all. No anastomotic breakdown was seen. Nor was any death attributable to any adverse effects of the treatment. Conclusion: The present results suggested that pre-operative intermediate-dose radiotherapy is effective in preventing pelvic recurrence in rectal cancer patients with acceptable toxicities.
| Original language | English |
|---|---|
| Pages (from-to) | 3013-3017 |
| Number of pages | 5 |
| Journal | Anticancer research |
| Volume | 22 |
| Issue number | 5 |
| Publication status | Published - 2002 Sep 1 |
Keywords
- Biologically effective dose
- Intermediate dose
- Pre-operative radiotherapy
- Rectal carcinoma
ASJC Scopus subject areas
- Oncology
- Cancer Research