International chronic ocular graft-vs-host-disease (GVHD) consensus group: Proposed diagnostic criteria for chronic GVHD (Part I)

Yoko Ogawa, Stella K. Kim, Reza Dana, Janine Clayton, Sandeep Jain, Mark I. Rosenblatt, Victor L. Perez, Hasanain Shikari, Anjo Riemens, Kazuo Tsubota

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

The International Chronic Ocular GVHD Consensus Group held 4 working meetings to define new diagnostic metrics for chronic ocular graft-versus-host disease (GVHD). After considering the factors currently used to diagnose chronic ocular GVHD, the Consensus Group identified 4 subjective and objective variables to measure in patients following allogeneic hematopoietic stem cell transplantation (HSCT): OSDI, Schirmer's score without anesthesia, corneal staining, and conjunctival injection. Each variable was scored 0-2 or 0-3, with a maximum composite score of 11. Consideration was also given to the presence or the absence of systemic GVHD. On the basis of their composite score and the presence or absence of systemic GVHD, patients were assigned to one of three diagnostic categories: NO, PROBABLE, or DEFINITE ocular GVHD. New diagnostic criteria for chronic ocular GVHD are presented by the Consensus Group. Validation studies are needed to identify the best combination of the proposed metrics to maximize diagnostic sensitivity and specificity.

Original languageEnglish
Article number3419
JournalScientific Reports
Volume3
DOIs
Publication statusPublished - 2013 Dec 5

Fingerprint

Graft vs Host Disease
Validation Studies
Hematopoietic Stem Cell Transplantation
Anesthesia
Staining and Labeling
Sensitivity and Specificity
Injections

ASJC Scopus subject areas

  • General

Cite this

International chronic ocular graft-vs-host-disease (GVHD) consensus group : Proposed diagnostic criteria for chronic GVHD (Part I). / Ogawa, Yoko; Kim, Stella K.; Dana, Reza; Clayton, Janine; Jain, Sandeep; Rosenblatt, Mark I.; Perez, Victor L.; Shikari, Hasanain; Riemens, Anjo; Tsubota, Kazuo.

In: Scientific Reports, Vol. 3, 3419, 05.12.2013.

Research output: Contribution to journalArticle

Ogawa, Yoko ; Kim, Stella K. ; Dana, Reza ; Clayton, Janine ; Jain, Sandeep ; Rosenblatt, Mark I. ; Perez, Victor L. ; Shikari, Hasanain ; Riemens, Anjo ; Tsubota, Kazuo. / International chronic ocular graft-vs-host-disease (GVHD) consensus group : Proposed diagnostic criteria for chronic GVHD (Part I). In: Scientific Reports. 2013 ; Vol. 3.
@article{37b62472b7a24bee9784dae799d36b65,
title = "International chronic ocular graft-vs-host-disease (GVHD) consensus group: Proposed diagnostic criteria for chronic GVHD (Part I)",
abstract = "The International Chronic Ocular GVHD Consensus Group held 4 working meetings to define new diagnostic metrics for chronic ocular graft-versus-host disease (GVHD). After considering the factors currently used to diagnose chronic ocular GVHD, the Consensus Group identified 4 subjective and objective variables to measure in patients following allogeneic hematopoietic stem cell transplantation (HSCT): OSDI, Schirmer's score without anesthesia, corneal staining, and conjunctival injection. Each variable was scored 0-2 or 0-3, with a maximum composite score of 11. Consideration was also given to the presence or the absence of systemic GVHD. On the basis of their composite score and the presence or absence of systemic GVHD, patients were assigned to one of three diagnostic categories: NO, PROBABLE, or DEFINITE ocular GVHD. New diagnostic criteria for chronic ocular GVHD are presented by the Consensus Group. Validation studies are needed to identify the best combination of the proposed metrics to maximize diagnostic sensitivity and specificity.",
author = "Yoko Ogawa and Kim, {Stella K.} and Reza Dana and Janine Clayton and Sandeep Jain and Rosenblatt, {Mark I.} and Perez, {Victor L.} and Hasanain Shikari and Anjo Riemens and Kazuo Tsubota",
year = "2013",
month = "12",
day = "5",
doi = "10.1038/srep03419",
language = "English",
volume = "3",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - International chronic ocular graft-vs-host-disease (GVHD) consensus group

T2 - Proposed diagnostic criteria for chronic GVHD (Part I)

AU - Ogawa, Yoko

AU - Kim, Stella K.

AU - Dana, Reza

AU - Clayton, Janine

AU - Jain, Sandeep

AU - Rosenblatt, Mark I.

AU - Perez, Victor L.

AU - Shikari, Hasanain

AU - Riemens, Anjo

AU - Tsubota, Kazuo

PY - 2013/12/5

Y1 - 2013/12/5

N2 - The International Chronic Ocular GVHD Consensus Group held 4 working meetings to define new diagnostic metrics for chronic ocular graft-versus-host disease (GVHD). After considering the factors currently used to diagnose chronic ocular GVHD, the Consensus Group identified 4 subjective and objective variables to measure in patients following allogeneic hematopoietic stem cell transplantation (HSCT): OSDI, Schirmer's score without anesthesia, corneal staining, and conjunctival injection. Each variable was scored 0-2 or 0-3, with a maximum composite score of 11. Consideration was also given to the presence or the absence of systemic GVHD. On the basis of their composite score and the presence or absence of systemic GVHD, patients were assigned to one of three diagnostic categories: NO, PROBABLE, or DEFINITE ocular GVHD. New diagnostic criteria for chronic ocular GVHD are presented by the Consensus Group. Validation studies are needed to identify the best combination of the proposed metrics to maximize diagnostic sensitivity and specificity.

AB - The International Chronic Ocular GVHD Consensus Group held 4 working meetings to define new diagnostic metrics for chronic ocular graft-versus-host disease (GVHD). After considering the factors currently used to diagnose chronic ocular GVHD, the Consensus Group identified 4 subjective and objective variables to measure in patients following allogeneic hematopoietic stem cell transplantation (HSCT): OSDI, Schirmer's score without anesthesia, corneal staining, and conjunctival injection. Each variable was scored 0-2 or 0-3, with a maximum composite score of 11. Consideration was also given to the presence or the absence of systemic GVHD. On the basis of their composite score and the presence or absence of systemic GVHD, patients were assigned to one of three diagnostic categories: NO, PROBABLE, or DEFINITE ocular GVHD. New diagnostic criteria for chronic ocular GVHD are presented by the Consensus Group. Validation studies are needed to identify the best combination of the proposed metrics to maximize diagnostic sensitivity and specificity.

UR - http://www.scopus.com/inward/record.url?scp=84890072447&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84890072447&partnerID=8YFLogxK

U2 - 10.1038/srep03419

DO - 10.1038/srep03419

M3 - Article

C2 - 24305504

AN - SCOPUS:84890072447

VL - 3

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 3419

ER -