International chronic ocular graft-vs-host-disease (GVHD) consensus group: Proposed diagnostic criteria for chronic GVHD (Part I)

Yoko Ogawa, Stella K. Kim, Reza Dana, Janine Clayton, Sandeep Jain, Mark I. Rosenblatt, Victor L. Perez, Hasanain Shikari, Anjo Riemens, Kazuo Tsubota

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

The International Chronic Ocular GVHD Consensus Group held 4 working meetings to define new diagnostic metrics for chronic ocular graft-versus-host disease (GVHD). After considering the factors currently used to diagnose chronic ocular GVHD, the Consensus Group identified 4 subjective and objective variables to measure in patients following allogeneic hematopoietic stem cell transplantation (HSCT): OSDI, Schirmer's score without anesthesia, corneal staining, and conjunctival injection. Each variable was scored 0-2 or 0-3, with a maximum composite score of 11. Consideration was also given to the presence or the absence of systemic GVHD. On the basis of their composite score and the presence or absence of systemic GVHD, patients were assigned to one of three diagnostic categories: NO, PROBABLE, or DEFINITE ocular GVHD. New diagnostic criteria for chronic ocular GVHD are presented by the Consensus Group. Validation studies are needed to identify the best combination of the proposed metrics to maximize diagnostic sensitivity and specificity.

Original languageEnglish
Article number3419
JournalScientific reports
Volume3
DOIs
Publication statusPublished - 2013 Dec 5

ASJC Scopus subject areas

  • General

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