International workshop: Radiation effects on mutation in somatic and germline stem cells

Yoshiaki Kodama, Asao Noda, Catherine Booth, David Breault, Toshio Suda, Jolyon Hendry, Takashi Shinohara, Claudia Rübe, Emi K. Nishimura, Hiroshi Mitani, Nori Nakamura, Ohtsura Niwa

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: New developments in knowledge of radiation effects on tissue stem cells were discussed in a Workshop held at the Radiation Effects Research Foundation (RERF) in Hiroshima, Japan, 1819 January 2012. Results: Stem cells and their niche in intestinal mucosa, haemopoietic tissue, hair follicles, and spermatogenesis were discussed variously with regard to radiosensitivity, repair, regeneration, age-dependency of effects, genetic effects, and protection aspects. These tissues all possess a common basic template, but there are structural and hierarchical differences between tissues which continue to be elucidated in terms of a stem-cell age structure and niche regulatory signals which together govern radiation responses. Conclusions: Stem cells and their niche have become much better characterized in recent years, and their radiation response can be elucidated in detail in experimental systems to help underpin both protection and therapeutic recommendations established from human epidemiological evidence. This report summarizes the presentations at the meeting, and concludes with some remaining questions which may be answered with the help of this type of research.

Original languageEnglish
Pages (from-to)501-506
Number of pages6
JournalInternational Journal of Radiation Biology
Volume88
Issue number6
DOIs
Publication statusPublished - 2012 Jun 1

Keywords

  • Age-dependent effects
  • Hereditary effects
  • Mutations
  • Protection
  • Stem cells and niche
  • Tissue radiation responses

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Kodama, Y., Noda, A., Booth, C., Breault, D., Suda, T., Hendry, J., Shinohara, T., Rübe, C., Nishimura, E. K., Mitani, H., Nakamura, N., & Niwa, O. (2012). International workshop: Radiation effects on mutation in somatic and germline stem cells. International Journal of Radiation Biology, 88(6), 501-506. https://doi.org/10.3109/09553002.2012.683512