TY - JOUR
T1 - International workshop
T2 - Radiation effects on mutation in somatic and germline stem cells
AU - Kodama, Yoshiaki
AU - Noda, Asao
AU - Booth, Catherine
AU - Breault, David
AU - Suda, Toshio
AU - Hendry, Jolyon
AU - Shinohara, Takashi
AU - Rübe, Claudia
AU - Nishimura, Emi K.
AU - Mitani, Hiroshi
AU - Nakamura, Nori
AU - Niwa, Ohtsura
N1 - Funding Information:
This Workshop was organized under the auspices of the Radiation Effects Research Foundation (RERF), Hiroshima, Japan. It was funded by the Japanese Ministry of Health, Labour and Welfare (MHLW). RERF, Hiroshima and Nagasaki, is a private, non-profit foundation funded by MHLW and the U.S. Department of Energy (DOE), the latter in part through DOE Award DE-HS0000031 to the National Academy of Sciences. This publication was supported by RERF Research Protocols RP #8 - 93 and #1 - 08. The views of the authors do not necessarily reflect those of the two governments.
PY - 2012/6
Y1 - 2012/6
N2 - Purpose: New developments in knowledge of radiation effects on tissue stem cells were discussed in a Workshop held at the Radiation Effects Research Foundation (RERF) in Hiroshima, Japan, 1819 January 2012. Results: Stem cells and their niche in intestinal mucosa, haemopoietic tissue, hair follicles, and spermatogenesis were discussed variously with regard to radiosensitivity, repair, regeneration, age-dependency of effects, genetic effects, and protection aspects. These tissues all possess a common basic template, but there are structural and hierarchical differences between tissues which continue to be elucidated in terms of a stem-cell age structure and niche regulatory signals which together govern radiation responses. Conclusions: Stem cells and their niche have become much better characterized in recent years, and their radiation response can be elucidated in detail in experimental systems to help underpin both protection and therapeutic recommendations established from human epidemiological evidence. This report summarizes the presentations at the meeting, and concludes with some remaining questions which may be answered with the help of this type of research.
AB - Purpose: New developments in knowledge of radiation effects on tissue stem cells were discussed in a Workshop held at the Radiation Effects Research Foundation (RERF) in Hiroshima, Japan, 1819 January 2012. Results: Stem cells and their niche in intestinal mucosa, haemopoietic tissue, hair follicles, and spermatogenesis were discussed variously with regard to radiosensitivity, repair, regeneration, age-dependency of effects, genetic effects, and protection aspects. These tissues all possess a common basic template, but there are structural and hierarchical differences between tissues which continue to be elucidated in terms of a stem-cell age structure and niche regulatory signals which together govern radiation responses. Conclusions: Stem cells and their niche have become much better characterized in recent years, and their radiation response can be elucidated in detail in experimental systems to help underpin both protection and therapeutic recommendations established from human epidemiological evidence. This report summarizes the presentations at the meeting, and concludes with some remaining questions which may be answered with the help of this type of research.
KW - Age-dependent effects
KW - Hereditary effects
KW - Mutations
KW - Protection
KW - Stem cells and niche
KW - Tissue radiation responses
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U2 - 10.3109/09553002.2012.683512
DO - 10.3109/09553002.2012.683512
M3 - Article
C2 - 22489999
AN - SCOPUS:84861917664
SN - 0955-3002
VL - 88
SP - 501
EP - 506
JO - International Journal of Radiation Biology
JF - International Journal of Radiation Biology
IS - 6
ER -