Abstract
A 66-year-old man was referred to our hospital for the treatment of refractory multiple myeloma with thalidomide. He had a history of an interstitial pneumonia of unknown etiology two months before admission. Eight days after starting 200 mg/ day of thalidomide, he developed dyspnea and fever, followed by a macropapular rash in the trunk. The dyspnea got worse and a CT scan revealed interstitial pneumonia 16 days after the treatment. He required mechanical ventilatory support. Bronchoalveolar lavage fluid revealed eosinophilia, suggesting a thalidomide-induced interstitial pneumonia. Thalidomide was discontinued and methylprednisolone (1000 mg/d x 3 days) was started, and the pneumonia and rash markedly improved within six days. After that the patient contracted MRSA pneumonia and died of MRSA septicemia.
Original language | English |
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Pages (from-to) | 1064-1066 |
Number of pages | 3 |
Journal | [Rinshō ketsueki] The Japanese journal of clinical hematology |
Volume | 45 |
Issue number | 9 |
Publication status | Published - 2004 Sep |
ASJC Scopus subject areas
- Medicine(all)