Abstract
A 66-year-old man was referred to our hospital for the treatment of refractory multiple myeloma with thalidomide. He had a history of an interstitial pneumonia of unknown etiology two months before admission. Eight days after starting 200 mg/ day of thalidomide, he developed dyspnea and fever, followed by a macropapular rash in the trunk. The dyspnea got worse and a CT scan revealed interstitial pneumonia 16 days after the treatment. He required mechanical ventilatory support. Bronchoalveolar lavage fluid revealed eosinophilia, suggesting a thalidomide-induced interstitial pneumonia. Thalidomide was discontinued and methylprednisolone (1000 mg/d x 3 days) was started, and the pneumonia and rash markedly improved within six days. After that the patient contracted MRSA pneumonia and died of MRSA septicemia.
| Original language | English |
|---|---|
| Pages (from-to) | 1064-1066 |
| Number of pages | 3 |
| Journal | [Rinshō ketsueki] The Japanese journal of clinical hematology |
| Volume | 45 |
| Issue number | 9 |
| Publication status | Published - 2004 |
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Interstitial pneumonia during treatment with thalidomide in a patient with multiple myeloma. / Iguchi, Toyotaka; Sakoda, Mariyo; Chen, Chien kang; Yokoyama, Kenji; Hattori, Yutaka; Ikeda, Yasuo; Okamoto, Shinichiro.
In: [Rinshō ketsueki] The Japanese journal of clinical hematology, Vol. 45, No. 9, 2004, p. 1064-1066.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interstitial pneumonia during treatment with thalidomide in a patient with multiple myeloma
AU - Iguchi, Toyotaka
AU - Sakoda, Mariyo
AU - Chen, Chien kang
AU - Yokoyama, Kenji
AU - Hattori, Yutaka
AU - Ikeda, Yasuo
AU - Okamoto, Shinichiro
PY - 2004
Y1 - 2004
N2 - A 66-year-old man was referred to our hospital for the treatment of refractory multiple myeloma with thalidomide. He had a history of an interstitial pneumonia of unknown etiology two months before admission. Eight days after starting 200 mg/ day of thalidomide, he developed dyspnea and fever, followed by a macropapular rash in the trunk. The dyspnea got worse and a CT scan revealed interstitial pneumonia 16 days after the treatment. He required mechanical ventilatory support. Bronchoalveolar lavage fluid revealed eosinophilia, suggesting a thalidomide-induced interstitial pneumonia. Thalidomide was discontinued and methylprednisolone (1000 mg/d x 3 days) was started, and the pneumonia and rash markedly improved within six days. After that the patient contracted MRSA pneumonia and died of MRSA septicemia.
AB - A 66-year-old man was referred to our hospital for the treatment of refractory multiple myeloma with thalidomide. He had a history of an interstitial pneumonia of unknown etiology two months before admission. Eight days after starting 200 mg/ day of thalidomide, he developed dyspnea and fever, followed by a macropapular rash in the trunk. The dyspnea got worse and a CT scan revealed interstitial pneumonia 16 days after the treatment. He required mechanical ventilatory support. Bronchoalveolar lavage fluid revealed eosinophilia, suggesting a thalidomide-induced interstitial pneumonia. Thalidomide was discontinued and methylprednisolone (1000 mg/d x 3 days) was started, and the pneumonia and rash markedly improved within six days. After that the patient contracted MRSA pneumonia and died of MRSA septicemia.
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UR - http://www.scopus.com/inward/citedby.url?scp=16544395329&partnerID=8YFLogxK
M3 - Article
C2 - 15510838
AN - SCOPUS:16544395329
VL - 45
SP - 1064
EP - 1066
JO - [Rinshō ketsueki] The Japanese journal of clinical hematology
JF - [Rinshō ketsueki] The Japanese journal of clinical hematology
SN - 0485-1439
IS - 9
ER -