Interstitial pneumonitis in a castration-resistant prostate cancer patient receiving cabazitaxel after thoracic radiation therapy: A case report

Yoshinori Yanai, Takeo Kosaka, Hiroshi Hongo, Mototsugu Oya

Research output: Contribution to journalArticle

Abstract

Background: Interstitial pneumonitis is a rare reaction in a previously irradiated area of pulmonary or thoracic lesion after treatment with anticancer drugs such as taxanes. Case presentation: A 66-year-old man presented with a fever and dyspnea after treatment with cabazitaxel for castration-resistant prostate cancer. He was treated with an intravenous broad-spectrum antimicrobial agent, however he complained of dyspnea and had a pulse oximetric saturation of 80% while breathing room air. The patients had been treated for bone metastases with 37.5 Gy to the thoracic spine (Th 7) as a local radiotherapy. Radiological images showed pulmonary interstitial opacities in the irradiated field of the both lungs. The steroid pulse therapy was started. The patient's dyspnea disappeared and the interstitial opacities had also improved. Conclusions: This report is a case of interstitial pneumonitis in a castration-resistant prostate cancer patient receiving cabazitaxel after thoracic radiation therapy.

Original languageEnglish
Article number720
JournalBMC Cancer
Volume19
Issue number1
DOIs
Publication statusPublished - 2019 Jul 22

Fingerprint

Castration
Interstitial Lung Diseases
Dyspnea
Prostatic Neoplasms
Radiotherapy
Thorax
Lung
Taxoids
Anti-Infective Agents
Respiration
Spine
Fever
Therapeutics
Steroids
Air
Neoplasm Metastasis
Bone and Bones
Pharmaceutical Preparations
cabazitaxel

Keywords

  • Cabazitaxel
  • Castration-resistant prostate cancer
  • Interstitial pneumonitis
  • Radiation recall pneumonitis
  • Thoracic radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

Cite this

Interstitial pneumonitis in a castration-resistant prostate cancer patient receiving cabazitaxel after thoracic radiation therapy : A case report. / Yanai, Yoshinori; Kosaka, Takeo; Hongo, Hiroshi; Oya, Mototsugu.

In: BMC Cancer, Vol. 19, No. 1, 720, 22.07.2019.

Research output: Contribution to journalArticle

@article{3028ed91f8d040498f64e4d64d7925bc,
title = "Interstitial pneumonitis in a castration-resistant prostate cancer patient receiving cabazitaxel after thoracic radiation therapy: A case report",
abstract = "Background: Interstitial pneumonitis is a rare reaction in a previously irradiated area of pulmonary or thoracic lesion after treatment with anticancer drugs such as taxanes. Case presentation: A 66-year-old man presented with a fever and dyspnea after treatment with cabazitaxel for castration-resistant prostate cancer. He was treated with an intravenous broad-spectrum antimicrobial agent, however he complained of dyspnea and had a pulse oximetric saturation of 80{\%} while breathing room air. The patients had been treated for bone metastases with 37.5 Gy to the thoracic spine (Th 7) as a local radiotherapy. Radiological images showed pulmonary interstitial opacities in the irradiated field of the both lungs. The steroid pulse therapy was started. The patient's dyspnea disappeared and the interstitial opacities had also improved. Conclusions: This report is a case of interstitial pneumonitis in a castration-resistant prostate cancer patient receiving cabazitaxel after thoracic radiation therapy.",
keywords = "Cabazitaxel, Castration-resistant prostate cancer, Interstitial pneumonitis, Radiation recall pneumonitis, Thoracic radiotherapy",
author = "Yoshinori Yanai and Takeo Kosaka and Hiroshi Hongo and Mototsugu Oya",
year = "2019",
month = "7",
day = "22",
doi = "10.1186/s12885-019-5942-4",
language = "English",
volume = "19",
journal = "BMC Cancer",
issn = "1471-2407",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Interstitial pneumonitis in a castration-resistant prostate cancer patient receiving cabazitaxel after thoracic radiation therapy

T2 - A case report

AU - Yanai, Yoshinori

AU - Kosaka, Takeo

AU - Hongo, Hiroshi

AU - Oya, Mototsugu

PY - 2019/7/22

Y1 - 2019/7/22

N2 - Background: Interstitial pneumonitis is a rare reaction in a previously irradiated area of pulmonary or thoracic lesion after treatment with anticancer drugs such as taxanes. Case presentation: A 66-year-old man presented with a fever and dyspnea after treatment with cabazitaxel for castration-resistant prostate cancer. He was treated with an intravenous broad-spectrum antimicrobial agent, however he complained of dyspnea and had a pulse oximetric saturation of 80% while breathing room air. The patients had been treated for bone metastases with 37.5 Gy to the thoracic spine (Th 7) as a local radiotherapy. Radiological images showed pulmonary interstitial opacities in the irradiated field of the both lungs. The steroid pulse therapy was started. The patient's dyspnea disappeared and the interstitial opacities had also improved. Conclusions: This report is a case of interstitial pneumonitis in a castration-resistant prostate cancer patient receiving cabazitaxel after thoracic radiation therapy.

AB - Background: Interstitial pneumonitis is a rare reaction in a previously irradiated area of pulmonary or thoracic lesion after treatment with anticancer drugs such as taxanes. Case presentation: A 66-year-old man presented with a fever and dyspnea after treatment with cabazitaxel for castration-resistant prostate cancer. He was treated with an intravenous broad-spectrum antimicrobial agent, however he complained of dyspnea and had a pulse oximetric saturation of 80% while breathing room air. The patients had been treated for bone metastases with 37.5 Gy to the thoracic spine (Th 7) as a local radiotherapy. Radiological images showed pulmonary interstitial opacities in the irradiated field of the both lungs. The steroid pulse therapy was started. The patient's dyspnea disappeared and the interstitial opacities had also improved. Conclusions: This report is a case of interstitial pneumonitis in a castration-resistant prostate cancer patient receiving cabazitaxel after thoracic radiation therapy.

KW - Cabazitaxel

KW - Castration-resistant prostate cancer

KW - Interstitial pneumonitis

KW - Radiation recall pneumonitis

KW - Thoracic radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=85069868336&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85069868336&partnerID=8YFLogxK

U2 - 10.1186/s12885-019-5942-4

DO - 10.1186/s12885-019-5942-4

M3 - Article

C2 - 31331293

AN - SCOPUS:85069868336

VL - 19

JO - BMC Cancer

JF - BMC Cancer

SN - 1471-2407

IS - 1

M1 - 720

ER -