Intestinal absorption mechanism of amphoteric β‐lactam antibiotics I: Comparative absorption and evidence for saturable transport of amino‐β‐iactam antibiotics by in situ rat small intestine

Akira Tsuji, Emi Nakashima, Izumi Kagami, Tsukinaka Yamana

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

The disappearance of various β‐lactam antibiotics from in situ rat small intestinal loops was studied at pH 7.4. For monobasic penicillins, despite the wide variety of apparent partition coefficients in is isobutyl alcohol‐water, the disappearance from the jejunal loops was almost 30% (±5% SD). On the other hand, the disappearance of amphoteric derivatives of penicillins and cephalosporins having very low lipid solubility varied widely between 12 and 80%. The peak blood levels after intraduodenal administration to the rats correlated well with the extent of disappearance of amphoteric penicillins from the intestinal loops. Absorption studies utilizing in situ intestinal loops were performed at variable dose ranges to yield a clear dose‐dependent disappearance. It is suggested that certain carrier‐mediated transport systems underlie the absorption mechanisms of amphoteric β‐lactam antibiotics.

Original languageEnglish
Pages (from-to)768-772
Number of pages5
JournalJournal of Pharmaceutical Sciences
Volume70
Issue number7
DOIs
Publication statusPublished - 1981 Jul

Keywords

  • Absorption, intestinal—mechanism proposed for saturable transport of amphoteric amino‐β‐lactam antibiotics, in situ rat intestinal loops
  • Aminocephalosporins—intestinal absorption mechanism proposed, compared with monobasic penicillins, in situ rat intestinal loops
  • Aminopenicillins—intestinal absorption mechanism proposed, compared with monobasic penicillins, in situ rat intestinal loops
  • Antibiotics, amino‐β‐lactam—compared with monobasic penicillins, intestinal absorption mechanism proposed, in situ rat intestinal loops

ASJC Scopus subject areas

  • Pharmaceutical Science

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