Intestinal and peri-tumoral lymphatic endothelial cells are resistant to radiation-induced apoptosis

Hoon Ki Sung; Tohru Morisada; Chung Hyun Cho; Yuichi Oike; Jayhun Lee; Eon Ki Sung; Jae Hoon Chung; Toshio Suda; Gou Young Koh

doi:10.1016/j.bbrc.2006.04.121

Intestinal and peri-tumoral lymphatic endothelial cells are resistant to radiation-induced apoptosis

Hoon Ki Sung, Tohru Morisada, Chung Hyun Cho, Yuichi Oike, Jayhun Lee, Eon Ki Sung, Jae Hoon Chung, Toshio Suda, Gou Young Koh

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Radiation therapy is a widely used cancer treatment, but it is unable to completely block cancer metastasis. The lymphatic vasculature serves as the primary route for metastatic spread, but little is known about how lymphatic endothelial cells respond to radiation. Here, we show that lymphatic endothelial cells in the small intestine and peri-tumor areas are highly resistant to radiation injury, while blood vessel endothelial cells in the small intestine are relatively sensitive. Our results suggest the need for alternative therapeutic modalities that can block lymphatic endothelial cell survival, and thus disrupt the integrity of lymphatic vessels in peri-tumor areas.

Original language	English
Pages (from-to)	545-551
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	345
Issue number	2
DOIs	https://doi.org/10.1016/j.bbrc.2006.04.121
Publication status	Published - 2006 Jun 30
Externally published	Yes

Keywords

Endothelial cells
Lymphatics
Radiation therapy
Tumor

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbrc.2006.04.121

Cite this

@article{b9827ece34b54df28203bdcf074780a1,

title = "Intestinal and peri-tumoral lymphatic endothelial cells are resistant to radiation-induced apoptosis",

abstract = "Radiation therapy is a widely used cancer treatment, but it is unable to completely block cancer metastasis. The lymphatic vasculature serves as the primary route for metastatic spread, but little is known about how lymphatic endothelial cells respond to radiation. Here, we show that lymphatic endothelial cells in the small intestine and peri-tumor areas are highly resistant to radiation injury, while blood vessel endothelial cells in the small intestine are relatively sensitive. Our results suggest the need for alternative therapeutic modalities that can block lymphatic endothelial cell survival, and thus disrupt the integrity of lymphatic vessels in peri-tumor areas.",

keywords = "Endothelial cells, Lymphatics, Radiation therapy, Tumor",

author = "Sung, {Hoon Ki} and Tohru Morisada and Cho, {Chung Hyun} and Yuichi Oike and Jayhun Lee and Sung, {Eon Ki} and Chung, {Jae Hoon} and Toshio Suda and Koh, {Gou Young}",

note = "Funding Information: We thank the members of Laboratory of Cell Biology in KRIBB for help in performing the irradiation of the mice, and Jennifer Macke for help in preparing the manuscript. Supported by a Grant of the KOSEF (F01-2004-000-10233-0) and National Research Laboratory Program (2004-02376), Ministry of Science and Technology, Republic of Korea.",

year = "2006",

month = jun,

day = "30",

doi = "10.1016/j.bbrc.2006.04.121",

language = "English",

volume = "345",

pages = "545--551",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Academic Press Inc.",

number = "2",

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TY - JOUR

T1 - Intestinal and peri-tumoral lymphatic endothelial cells are resistant to radiation-induced apoptosis

AU - Sung, Hoon Ki

AU - Morisada, Tohru

AU - Cho, Chung Hyun

AU - Oike, Yuichi

AU - Lee, Jayhun

AU - Sung, Eon Ki

AU - Chung, Jae Hoon

AU - Suda, Toshio

AU - Koh, Gou Young

N1 - Funding Information: We thank the members of Laboratory of Cell Biology in KRIBB for help in performing the irradiation of the mice, and Jennifer Macke for help in preparing the manuscript. Supported by a Grant of the KOSEF (F01-2004-000-10233-0) and National Research Laboratory Program (2004-02376), Ministry of Science and Technology, Republic of Korea.

PY - 2006/6/30

Y1 - 2006/6/30

N2 - Radiation therapy is a widely used cancer treatment, but it is unable to completely block cancer metastasis. The lymphatic vasculature serves as the primary route for metastatic spread, but little is known about how lymphatic endothelial cells respond to radiation. Here, we show that lymphatic endothelial cells in the small intestine and peri-tumor areas are highly resistant to radiation injury, while blood vessel endothelial cells in the small intestine are relatively sensitive. Our results suggest the need for alternative therapeutic modalities that can block lymphatic endothelial cell survival, and thus disrupt the integrity of lymphatic vessels in peri-tumor areas.

AB - Radiation therapy is a widely used cancer treatment, but it is unable to completely block cancer metastasis. The lymphatic vasculature serves as the primary route for metastatic spread, but little is known about how lymphatic endothelial cells respond to radiation. Here, we show that lymphatic endothelial cells in the small intestine and peri-tumor areas are highly resistant to radiation injury, while blood vessel endothelial cells in the small intestine are relatively sensitive. Our results suggest the need for alternative therapeutic modalities that can block lymphatic endothelial cell survival, and thus disrupt the integrity of lymphatic vessels in peri-tumor areas.

KW - Endothelial cells

KW - Lymphatics

KW - Radiation therapy

KW - Tumor

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UR - http://www.scopus.com/inward/citedby.url?scp=33646844096&partnerID=8YFLogxK

U2 - 10.1016/j.bbrc.2006.04.121

DO - 10.1016/j.bbrc.2006.04.121

M3 - Article

C2 - 16690025

AN - SCOPUS:33646844096

SN - 0006-291X

VL - 345

SP - 545

EP - 551

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

Intestinal and peri-tumoral lymphatic endothelial cells are resistant to radiation-induced apoptosis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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