Intestinal and peri-tumoral lymphatic endothelial cells are resistant to radiation-induced apoptosis

Hoon Ki Sung, Tohru Morisada, Chung Hyun Cho, Yuichi Oike, Jayhun Lee, Eon Ki Sung, Jae Hoon Chung, Toshio Suda, Gou Young Koh

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Radiation therapy is a widely used cancer treatment, but it is unable to completely block cancer metastasis. The lymphatic vasculature serves as the primary route for metastatic spread, but little is known about how lymphatic endothelial cells respond to radiation. Here, we show that lymphatic endothelial cells in the small intestine and peri-tumor areas are highly resistant to radiation injury, while blood vessel endothelial cells in the small intestine are relatively sensitive. Our results suggest the need for alternative therapeutic modalities that can block lymphatic endothelial cell survival, and thus disrupt the integrity of lymphatic vessels in peri-tumor areas.

Original languageEnglish
Pages (from-to)545-551
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume345
Issue number2
DOIs
Publication statusPublished - 2006 Jun 30

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Keywords

  • Endothelial cells
  • Lymphatics
  • Radiation therapy
  • Tumor

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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