TY - JOUR
T1 - Intestinal commensal microbes as immune modulators
AU - Ivanov, Ivaylo I.
AU - Honda, Kenya
N1 - Funding Information:
This work was supported by grants to K.H. from Japan Science and Technology Agency for CREST, the Japan Society for the Promotion of Science NEXT program, and the Waksman Foundation of Japan Inc., and by grants to I.I.I. from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the Crohn's and Colitis Foundation of America (CCFA).
PY - 2012/10/18
Y1 - 2012/10/18
N2 - Commensal bacteria are necessary for the development and maintenance of a healthy immune system. Harnessing the ability of microbiota to affect host immunity is considered an important therapeutic strategy for many mucosal and nonmucosal immune-related conditions, such as inflammatory bowel diseases (IBDs), celiac disease, metabolic syndrome, diabetes, and microbial infections. In addition to well-established immunostimulatory effects of the microbiota, the presence of individual mutualistic commensal bacteria with immunomodulatory effects has been described. These organisms are permanent members of the commensal microbiota and affect host immune homeostasis in specific ways. Identification of individual examples of such immunomodulatory commensals and understanding their mechanisms of interaction with the host will be invaluable in designing therapeutic strategies to reverse intestinal dysbiosis and recover immunological homeostasis.
AB - Commensal bacteria are necessary for the development and maintenance of a healthy immune system. Harnessing the ability of microbiota to affect host immunity is considered an important therapeutic strategy for many mucosal and nonmucosal immune-related conditions, such as inflammatory bowel diseases (IBDs), celiac disease, metabolic syndrome, diabetes, and microbial infections. In addition to well-established immunostimulatory effects of the microbiota, the presence of individual mutualistic commensal bacteria with immunomodulatory effects has been described. These organisms are permanent members of the commensal microbiota and affect host immune homeostasis in specific ways. Identification of individual examples of such immunomodulatory commensals and understanding their mechanisms of interaction with the host will be invaluable in designing therapeutic strategies to reverse intestinal dysbiosis and recover immunological homeostasis.
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U2 - 10.1016/j.chom.2012.09.009
DO - 10.1016/j.chom.2012.09.009
M3 - Review article
C2 - 23084918
AN - SCOPUS:84867658789
SN - 1931-3128
VL - 12
SP - 496
EP - 508
JO - Cell Host and Microbe
JF - Cell Host and Microbe
IS - 4
ER -
