Intracellular efavirenz levels in peripheral blood mononuclear cells from human immunodeficiency virus-infected individuals

Rie Tanaka, Hideji Hanabusa, Ei Kinai, Naoki Hasegawa, Masayoshi Negishi, Shingo Kato

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

We describe a novel method for isolating plasma-free peripheral blood mononuclear cells retaining intracellular efavirenz. Quantification of efavirenz in 13 human immunodeficiency virus-infected patients by liquid chromatography-tandem mass spectrometry showed a higher correlation of intracellular levels with unbound plasma levels (accumulation ratio, 1,190) than with total plasma levels.

Original languageEnglish
Pages (from-to)782-785
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume52
Issue number2
DOIs
Publication statusPublished - 2008 Feb

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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