Intracellular efavirenz levels in peripheral blood mononuclear cells from human immunodeficiency virus-infected individuals

Rie Tanaka, Hideji Hanabusa, Ei Kinai, Naoki Hasegawa, Masayoshi Negishi, Shingo Kato

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We describe a novel method for isolating plasma-free peripheral blood mononuclear cells retaining intracellular efavirenz. Quantification of efavirenz in 13 human immunodeficiency virus-infected patients by liquid chromatography-tandem mass spectrometry showed a higher correlation of intracellular levels with unbound plasma levels (accumulation ratio, 1,190) than with total plasma levels.

Original languageEnglish
Pages (from-to)782-785
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume52
Issue number2
DOIs
Publication statusPublished - 2008 Feb

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efavirenz
Blood Cells
HIV
Tandem Mass Spectrometry
Liquid Chromatography

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Intracellular efavirenz levels in peripheral blood mononuclear cells from human immunodeficiency virus-infected individuals. / Tanaka, Rie; Hanabusa, Hideji; Kinai, Ei; Hasegawa, Naoki; Negishi, Masayoshi; Kato, Shingo.

In: Antimicrobial Agents and Chemotherapy, Vol. 52, No. 2, 02.2008, p. 782-785.

Research output: Contribution to journalArticle

Tanaka, Rie ; Hanabusa, Hideji ; Kinai, Ei ; Hasegawa, Naoki ; Negishi, Masayoshi ; Kato, Shingo. / Intracellular efavirenz levels in peripheral blood mononuclear cells from human immunodeficiency virus-infected individuals. In: Antimicrobial Agents and Chemotherapy. 2008 ; Vol. 52, No. 2. pp. 782-785.
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