TY - JOUR
T1 - Intracellular efavirenz levels in peripheral blood mononuclear cells from human immunodeficiency virus-infected individuals
AU - Tanaka, Rie
AU - Hanabusa, Hideji
AU - Kinai, Ei
AU - Hasegawa, Naoki
AU - Negishi, Masayoshi
AU - Kato, Shingo
PY - 2008/2
Y1 - 2008/2
N2 - We describe a novel method for isolating plasma-free peripheral blood mononuclear cells retaining intracellular efavirenz. Quantification of efavirenz in 13 human immunodeficiency virus-infected patients by liquid chromatography-tandem mass spectrometry showed a higher correlation of intracellular levels with unbound plasma levels (accumulation ratio, 1,190) than with total plasma levels.
AB - We describe a novel method for isolating plasma-free peripheral blood mononuclear cells retaining intracellular efavirenz. Quantification of efavirenz in 13 human immunodeficiency virus-infected patients by liquid chromatography-tandem mass spectrometry showed a higher correlation of intracellular levels with unbound plasma levels (accumulation ratio, 1,190) than with total plasma levels.
UR - http://www.scopus.com/inward/record.url?scp=38649112298&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38649112298&partnerID=8YFLogxK
U2 - 10.1128/AAC.01613-06
DO - 10.1128/AAC.01613-06
M3 - Article
C2 - 18070970
AN - SCOPUS:38649112298
SN - 0066-4804
VL - 52
SP - 782
EP - 785
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 2
ER -
