TY - GEN
T1 - INTRACELLULAR TRANSPORT ROUTE OF ALBUMIN IN CULTURED AORTIC ENDOTHELIAL CELLS
AU - Ikezawa, Kenji
AU - Ueno, Kazuki
AU - Ikeda, Mariko
AU - Oka, Kotaro
AU - Tanishita, Kazuo
N1 - Funding Information:
This work was partially supported by Grant-in-Aid for Scientific Research (B) from the Ministry of Education, Science. Sports and Culture in Japan and Keio University Research Fund.
Publisher Copyright:
© 1998 American Society of Mechanical Engineers (ASME). All rights reserved.
PY - 1998
Y1 - 1998
N2 - Effects of colchicine on intracellular albumin transport in aortic endothelial cells have been shown as a reduction of the endocytic activity (Liu et al., 1993) and albumin transcytosis (Antohe et al., 1993). Since microtubules are possibly involved in the movement of vesicles, it is important to understand that microtubules are associated with albumin transport within cells. In our in vitro study, the organization of endocytic compartments were analyzed after internalization of fluorescent-labeled albumin in cultured porcine aortic endothelial cells. We found that microtubules were not only involved in a later step but also early step of endocytosis (containing internalization).
AB - Effects of colchicine on intracellular albumin transport in aortic endothelial cells have been shown as a reduction of the endocytic activity (Liu et al., 1993) and albumin transcytosis (Antohe et al., 1993). Since microtubules are possibly involved in the movement of vesicles, it is important to understand that microtubules are associated with albumin transport within cells. In our in vitro study, the organization of endocytic compartments were analyzed after internalization of fluorescent-labeled albumin in cultured porcine aortic endothelial cells. We found that microtubules were not only involved in a later step but also early step of endocytosis (containing internalization).
UR - http://www.scopus.com/inward/record.url?scp=85124390889&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85124390889&partnerID=8YFLogxK
U2 - 10.1115/imece1998-0053
DO - 10.1115/imece1998-0053
M3 - Conference contribution
AN - SCOPUS:85124390889
T3 - ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
SP - 107
EP - 108
BT - Advances in Bioengineering
PB - American Society of Mechanical Engineers (ASME)
T2 - ASME 1998 International Mechanical Engineering Congress and Exposition, IMECE 1998
Y2 - 15 November 1998 through 20 November 1998
ER -