Intracerebroventricular injection of brain natriuretic peptide inhibits vasopressin secretion in conscious rats

T. Yamada, K. Nakao, Hiroshi Itoh, G. Shirakami, K. Kangawa, N. Minamino, H. Matsuo, H. Imura

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The effect of intracerebroventricular (i.c.v.) injection of brain natriuretic peptide (BNP), a novel peptide purified from the porcine brain, on arginine vasopressin (AVP) secretion was studied in conscious, unrestrained rats and was compared with that of atrial natriuretic polypeptide (ANP). I.c.v. administration of BNP (0.01, 0.1 or 1 nmol) significantly inhibited basal AVP secretion and the effect of BNP was comparable to that of ANP. The AVP secretion induced by i.c.v. injection of angiotensin II (0.1 nmol) was significantly suppressed by the pretreatment with BNP (0.1 or 1 nmol). These results suggest that BNP is involved in the central control of AVP secretion either alone or in combination with brain ANP.

Original languageEnglish
Pages (from-to)223-228
Number of pages6
JournalNeuroscience Letters
Volume95
Issue number1-3
DOIs
Publication statusPublished - 1988 Dec 19
Externally publishedYes

Fingerprint

Brain Natriuretic Peptide
Vasopressins
Arginine Vasopressin
Injections
Peptides
Brain
Angiotensin II
Swine

Keywords

  • Angiotensin II
  • Arginine vasopressin
  • Atrial natriuretic polypeptide
  • Brain natriuretic peptide

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Intracerebroventricular injection of brain natriuretic peptide inhibits vasopressin secretion in conscious rats. / Yamada, T.; Nakao, K.; Itoh, Hiroshi; Shirakami, G.; Kangawa, K.; Minamino, N.; Matsuo, H.; Imura, H.

In: Neuroscience Letters, Vol. 95, No. 1-3, 19.12.1988, p. 223-228.

Research output: Contribution to journalArticle

Yamada, T, Nakao, K, Itoh, H, Shirakami, G, Kangawa, K, Minamino, N, Matsuo, H & Imura, H 1988, 'Intracerebroventricular injection of brain natriuretic peptide inhibits vasopressin secretion in conscious rats', Neuroscience Letters, vol. 95, no. 1-3, pp. 223-228. https://doi.org/10.1016/0304-3940(88)90661-1
Yamada, T. ; Nakao, K. ; Itoh, Hiroshi ; Shirakami, G. ; Kangawa, K. ; Minamino, N. ; Matsuo, H. ; Imura, H. / Intracerebroventricular injection of brain natriuretic peptide inhibits vasopressin secretion in conscious rats. In: Neuroscience Letters. 1988 ; Vol. 95, No. 1-3. pp. 223-228.
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AU - Minamino, N.

AU - Matsuo, H.

AU - Imura, H.

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