Intracoronary endothelin-1 increases coronary retrograde pressure by constricting arterioles

Keiichi Fukuda, Shingo Hori, Masatoshi Kusuhara, Toru Satoh, Shingo Kyotani, Soushin Inoue, Hideto Ohno, Ken Yamaguchi, Shunnosuke Handa, Yoshiro Nakamura

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Abstract

Study objective - The aim was to determine the site of coronary vasoconstriction induced by endothelin, by investigating the response in terms of retrograde pressure and reactive hyperaemia.Experimental material - Twelve anaesthetised mongrel dogs, 12-14 kg, were used for the studies.Design - The left anterior descending coronary artery was cannulated and perfused with blood through an extracorporeal bypass. The effects of intracoronary endothelin-l (1-500 pmol) on coronary blood flow, coronary flow reserve (the peak reactive flow and the repayment after 15 s coronary occlusion), and retrograde coronary pressure during coronary occlusion were studied (n=7). The retrograde coronary flow was collected from the bypass at each dose (n=5).Measurements and main results - At doses of greater than 20 pmol the coronary flow decreased dose dependently and reached almost zero flow at 500 pmol. The coronary flow reserve also decreased; however, the retrograde pressure was raised dose dependently at doses of greater than 10 pmol. At a dose of 500 pmol, the retrograde pressure was increased to 61 mm Hg [82(SEM 12)% of the coronary perfusion pressure]. Retrograde flow remained unchanged throughout the experiment.Conclusions - The endothelin-1 induced rise in retrograde pressure is in accordance with a dose dependent reduction in coronary flow reserve, and collateral flow was not augmented by endothelin. It is concluded that the effect of endothelin-1 on coronary circulation in situ was mainly due to the constriction of small resistant vessels.

Original languageEnglish
Pages (from-to)987-992
Number of pages6
JournalCardiovascular Research
Volume24
Issue number12
DOIs
Publication statusPublished - 1990 Jan 1

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Keywords

  • Collateral circulation
  • Coronary circulation
  • Coronary retrograde flow
  • Coronary retrograde pressure
  • Coronary spasm
  • Endothelin-1
  • Resistance vessel
  • Vasoconstriction

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Fukuda, K., Hori, S., Kusuhara, M., Satoh, T., Kyotani, S., Inoue, S., Ohno, H., Yamaguchi, K., Handa, S., & Nakamura, Y. (1990). Intracoronary endothelin-1 increases coronary retrograde pressure by constricting arterioles. Cardiovascular Research, 24(12), 987-992. https://doi.org/10.1093/cvr/24.12.987