Intracoronary endothelin-1 increases coronary retrograde pressure by constricting arterioles

Keiichi Fukuda, Shingo Hori, Masatoshi Kusuhara, Toru Satoh, Shingo Kyotani, Soushin Inoue, Hideto Ohno, Ken Yamaguchi, Shunnosuke Handa, Yoshiro Nakamura

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Study objective - The aim was to determine the site of coronary vasoconstriction induced by endothelin, by investigating the response in terms of retrograde pressure and reactive hyperaemia.Experimental material - Twelve anaesthetised mongrel dogs, 12-14 kg, were used for the studies.Design - The left anterior descending coronary artery was cannulated and perfused with blood through an extracorporeal bypass. The effects of intracoronary endothelin-l (1-500 pmol) on coronary blood flow, coronary flow reserve (the peak reactive flow and the repayment after 15 s coronary occlusion), and retrograde coronary pressure during coronary occlusion were studied (n=7). The retrograde coronary flow was collected from the bypass at each dose (n=5).Measurements and main results - At doses of greater than 20 pmol the coronary flow decreased dose dependently and reached almost zero flow at 500 pmol. The coronary flow reserve also decreased; however, the retrograde pressure was raised dose dependently at doses of greater than 10 pmol. At a dose of 500 pmol, the retrograde pressure was increased to 61 mm Hg [82(SEM 12)% of the coronary perfusion pressure]. Retrograde flow remained unchanged throughout the experiment.Conclusions - The endothelin-1 induced rise in retrograde pressure is in accordance with a dose dependent reduction in coronary flow reserve, and collateral flow was not augmented by endothelin. It is concluded that the effect of endothelin-1 on coronary circulation in situ was mainly due to the constriction of small resistant vessels.

Original languageEnglish
Pages (from-to)987-992
Number of pages6
JournalCardiovascular Research
Volume24
Issue number12
DOIs
Publication statusPublished - 1990 Jan 1

Fingerprint

Arterioles
Endothelin-1
Pressure
Coronary Occlusion
Endothelins
Coronary Circulation
Hyperemia
Vasoconstriction
Constriction
Coronary Vessels
Perfusion
Dogs

Keywords

  • Collateral circulation
  • Coronary circulation
  • Coronary retrograde flow
  • Coronary retrograde pressure
  • Coronary spasm
  • Endothelin-1
  • Resistance vessel
  • Vasoconstriction

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Intracoronary endothelin-1 increases coronary retrograde pressure by constricting arterioles. / Fukuda, Keiichi; Hori, Shingo; Kusuhara, Masatoshi; Satoh, Toru; Kyotani, Shingo; Inoue, Soushin; Ohno, Hideto; Yamaguchi, Ken; Handa, Shunnosuke; Nakamura, Yoshiro.

In: Cardiovascular Research, Vol. 24, No. 12, 01.01.1990, p. 987-992.

Research output: Contribution to journalReview article

Fukuda, K, Hori, S, Kusuhara, M, Satoh, T, Kyotani, S, Inoue, S, Ohno, H, Yamaguchi, K, Handa, S & Nakamura, Y 1990, 'Intracoronary endothelin-1 increases coronary retrograde pressure by constricting arterioles', Cardiovascular Research, vol. 24, no. 12, pp. 987-992. https://doi.org/10.1093/cvr/24.12.987
Fukuda, Keiichi ; Hori, Shingo ; Kusuhara, Masatoshi ; Satoh, Toru ; Kyotani, Shingo ; Inoue, Soushin ; Ohno, Hideto ; Yamaguchi, Ken ; Handa, Shunnosuke ; Nakamura, Yoshiro. / Intracoronary endothelin-1 increases coronary retrograde pressure by constricting arterioles. In: Cardiovascular Research. 1990 ; Vol. 24, No. 12. pp. 987-992.
@article{633971cd9b7d4aa3afe1b3e1c5b328f3,
title = "Intracoronary endothelin-1 increases coronary retrograde pressure by constricting arterioles",
abstract = "Study objective - The aim was to determine the site of coronary vasoconstriction induced by endothelin, by investigating the response in terms of retrograde pressure and reactive hyperaemia.Experimental material - Twelve anaesthetised mongrel dogs, 12-14 kg, were used for the studies.Design - The left anterior descending coronary artery was cannulated and perfused with blood through an extracorporeal bypass. The effects of intracoronary endothelin-l (1-500 pmol) on coronary blood flow, coronary flow reserve (the peak reactive flow and the repayment after 15 s coronary occlusion), and retrograde coronary pressure during coronary occlusion were studied (n=7). The retrograde coronary flow was collected from the bypass at each dose (n=5).Measurements and main results - At doses of greater than 20 pmol the coronary flow decreased dose dependently and reached almost zero flow at 500 pmol. The coronary flow reserve also decreased; however, the retrograde pressure was raised dose dependently at doses of greater than 10 pmol. At a dose of 500 pmol, the retrograde pressure was increased to 61 mm Hg [82(SEM 12){\%} of the coronary perfusion pressure]. Retrograde flow remained unchanged throughout the experiment.Conclusions - The endothelin-1 induced rise in retrograde pressure is in accordance with a dose dependent reduction in coronary flow reserve, and collateral flow was not augmented by endothelin. It is concluded that the effect of endothelin-1 on coronary circulation in situ was mainly due to the constriction of small resistant vessels.",
keywords = "Collateral circulation, Coronary circulation, Coronary retrograde flow, Coronary retrograde pressure, Coronary spasm, Endothelin-1, Resistance vessel, Vasoconstriction",
author = "Keiichi Fukuda and Shingo Hori and Masatoshi Kusuhara and Toru Satoh and Shingo Kyotani and Soushin Inoue and Hideto Ohno and Ken Yamaguchi and Shunnosuke Handa and Yoshiro Nakamura",
year = "1990",
month = "1",
day = "1",
doi = "10.1093/cvr/24.12.987",
language = "English",
volume = "24",
pages = "987--992",
journal = "Cardiovascular Research",
issn = "0008-6363",
publisher = "Oxford University Press",
number = "12",

}

TY - JOUR

T1 - Intracoronary endothelin-1 increases coronary retrograde pressure by constricting arterioles

AU - Fukuda, Keiichi

AU - Hori, Shingo

AU - Kusuhara, Masatoshi

AU - Satoh, Toru

AU - Kyotani, Shingo

AU - Inoue, Soushin

AU - Ohno, Hideto

AU - Yamaguchi, Ken

AU - Handa, Shunnosuke

AU - Nakamura, Yoshiro

PY - 1990/1/1

Y1 - 1990/1/1

N2 - Study objective - The aim was to determine the site of coronary vasoconstriction induced by endothelin, by investigating the response in terms of retrograde pressure and reactive hyperaemia.Experimental material - Twelve anaesthetised mongrel dogs, 12-14 kg, were used for the studies.Design - The left anterior descending coronary artery was cannulated and perfused with blood through an extracorporeal bypass. The effects of intracoronary endothelin-l (1-500 pmol) on coronary blood flow, coronary flow reserve (the peak reactive flow and the repayment after 15 s coronary occlusion), and retrograde coronary pressure during coronary occlusion were studied (n=7). The retrograde coronary flow was collected from the bypass at each dose (n=5).Measurements and main results - At doses of greater than 20 pmol the coronary flow decreased dose dependently and reached almost zero flow at 500 pmol. The coronary flow reserve also decreased; however, the retrograde pressure was raised dose dependently at doses of greater than 10 pmol. At a dose of 500 pmol, the retrograde pressure was increased to 61 mm Hg [82(SEM 12)% of the coronary perfusion pressure]. Retrograde flow remained unchanged throughout the experiment.Conclusions - The endothelin-1 induced rise in retrograde pressure is in accordance with a dose dependent reduction in coronary flow reserve, and collateral flow was not augmented by endothelin. It is concluded that the effect of endothelin-1 on coronary circulation in situ was mainly due to the constriction of small resistant vessels.

AB - Study objective - The aim was to determine the site of coronary vasoconstriction induced by endothelin, by investigating the response in terms of retrograde pressure and reactive hyperaemia.Experimental material - Twelve anaesthetised mongrel dogs, 12-14 kg, were used for the studies.Design - The left anterior descending coronary artery was cannulated and perfused with blood through an extracorporeal bypass. The effects of intracoronary endothelin-l (1-500 pmol) on coronary blood flow, coronary flow reserve (the peak reactive flow and the repayment after 15 s coronary occlusion), and retrograde coronary pressure during coronary occlusion were studied (n=7). The retrograde coronary flow was collected from the bypass at each dose (n=5).Measurements and main results - At doses of greater than 20 pmol the coronary flow decreased dose dependently and reached almost zero flow at 500 pmol. The coronary flow reserve also decreased; however, the retrograde pressure was raised dose dependently at doses of greater than 10 pmol. At a dose of 500 pmol, the retrograde pressure was increased to 61 mm Hg [82(SEM 12)% of the coronary perfusion pressure]. Retrograde flow remained unchanged throughout the experiment.Conclusions - The endothelin-1 induced rise in retrograde pressure is in accordance with a dose dependent reduction in coronary flow reserve, and collateral flow was not augmented by endothelin. It is concluded that the effect of endothelin-1 on coronary circulation in situ was mainly due to the constriction of small resistant vessels.

KW - Collateral circulation

KW - Coronary circulation

KW - Coronary retrograde flow

KW - Coronary retrograde pressure

KW - Coronary spasm

KW - Endothelin-1

KW - Resistance vessel

KW - Vasoconstriction

UR - http://www.scopus.com/inward/record.url?scp=85047678842&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047678842&partnerID=8YFLogxK

U2 - 10.1093/cvr/24.12.987

DO - 10.1093/cvr/24.12.987

M3 - Review article

C2 - 2097065

AN - SCOPUS:85047678842

VL - 24

SP - 987

EP - 992

JO - Cardiovascular Research

JF - Cardiovascular Research

SN - 0008-6363

IS - 12

ER -