Intraductal dissemination of papillary adenocarcinoma of the ampulla of Vater in the pancreatic duct

Akiko Matsubara, Satoshi Nara, Shigeki Sekine, Hidenori Ojima, Tomoo Kosuge, Kazuaki Shimada, Ryoji Kushima, Yae Kanai, Nobuyoshi Hiraoka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

It has been speculated that intraductal dissemination, via the pancreatic duct, bile duct, or mammary duct, is a unique form of cancer cell spread. However, clinical evidence to confirm this form of dissemination has been lacking. Here we report a case of papillary adenocarcinoma of the ampulla of Vater in which retrograde dissemination to the pancreatic duct was strongly suggested. A 79-year-old woman underwent pancreatoduodenectomy for a 22mm microinvasive papillary adenocarcinoma of the ampulla. Multiple carcinomas in situ were found in the pancreatic duct distant from the ampulla. Seven months later, she underwent a second operation for a recurrent papillary adenocarcinoma at the pancreato-jejunal anastomosis showing exophytic and expansive growth into the jejunal lumen that connected to an intraductal adenocarcinoma in the pancreatic body. None of these tumors showed invasive growth, or vascular or neural invasion, being separate from each other but sharing identical histological, immunohistochemical, and molecular features; papillary growth, a pancreatobiliary phenotype, the same pattern of genomic loss of heterozygosity, and no mutation of the KRAS, TP53, and GNAS genes. These results imply that this papillary adenocarcinoma of the ampulla of Vater had disseminated to the pancreatic duct in a retrograde manner and recurred in the remnant pancreas.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalPathology International
Volume64
Issue number1
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Papillary Adenocarcinoma
Ampulla of Vater
Pancreatic Ducts
Growth
Pancreaticoduodenectomy
Loss of Heterozygosity
p53 Genes
Carcinoma in Situ
Bile Ducts
Blood Vessels
Pancreas
Neoplasms
Adenocarcinoma
Breast
Phenotype
Mutation

Keywords

  • Ampulla of Vater
  • Intraductal dissemination
  • Pancreatic duct
  • Papillary adenocarcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Intraductal dissemination of papillary adenocarcinoma of the ampulla of Vater in the pancreatic duct. / Matsubara, Akiko; Nara, Satoshi; Sekine, Shigeki; Ojima, Hidenori; Kosuge, Tomoo; Shimada, Kazuaki; Kushima, Ryoji; Kanai, Yae; Hiraoka, Nobuyoshi.

In: Pathology International, Vol. 64, No. 1, 2014, p. 39-44.

Research output: Contribution to journalArticle

Matsubara, A, Nara, S, Sekine, S, Ojima, H, Kosuge, T, Shimada, K, Kushima, R, Kanai, Y & Hiraoka, N 2014, 'Intraductal dissemination of papillary adenocarcinoma of the ampulla of Vater in the pancreatic duct', Pathology International, vol. 64, no. 1, pp. 39-44. https://doi.org/10.1111/pin.12131
Matsubara, Akiko ; Nara, Satoshi ; Sekine, Shigeki ; Ojima, Hidenori ; Kosuge, Tomoo ; Shimada, Kazuaki ; Kushima, Ryoji ; Kanai, Yae ; Hiraoka, Nobuyoshi. / Intraductal dissemination of papillary adenocarcinoma of the ampulla of Vater in the pancreatic duct. In: Pathology International. 2014 ; Vol. 64, No. 1. pp. 39-44.
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