Abstract
Clinicopathological features of 28 patients with intraductal papillary tumor (IDPT) and 10 patients with mucinous cystic tumor (MCT) of the pancreas were studied. Both IDPT and MCT showed papillary projections of the epithelium with abundant mucus secretion in the ectatic ducts or cystic spaces. The patients with IDPT comprised 19 men and 9 women with a mean age of 64.9 years. Three fourths of the IDPTs were located in the pancreatic head, and the mean tumor size was 9.5 cm. Local recurrence was observed in one patient, but none died of IDPT. In contrasts all patients with MCT were women, with a mean age of 49.4 years. None of the MCTs arose in the head, and the mean tumor size was 7.1 cm. One patient died of MCT, but all of the others survived without recurrence. Eight IDPTs and three MCTs showed invasion into the surrounding pancreatic tissue. Muconodular infiltration was mainly observed in five IDPTs and one MCTs and tubular infiltration in three IDPTs and two MCTs. A characteristic histological finding associated with the muconodular infiltration in IDPT was subepithelial 'mucin droplets' that appeared to represent a change in polarity of mucus secretion. The formation of such subepithelial 'mucin droplets' may he the initial step of muconodular infiltration in IDPT. Muconodular infiltration in IDPT appears different morphologically and biologically from the mucinous carcinoma subtype of conventional invasive ductal carcinorma.
| Original language | English |
|---|---|
| Pages (from-to) | 1010-1017 |
| Number of pages | 8 |
| Journal | Human Pathology |
| Volume | 28 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 1997 |
| Externally published | Yes |
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Keywords
- Intraductal papillary tumor
- Mucinous cystic tumor
- Muconodular infiltration
- Pancreatic tumor
- Tubular infiltration
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Intraductal papillary tumors and mucinous cystic tumors of the pancreas : Clinicopathologic study of 38 cases. / Fukushima, Noriyoshi; Mukai, Kiyoshi; Kanai, Yae; Hasebe, Takahiro; Shimada, Kazuaki; Ozaki, Hideo; Kinoshita, Taira; Kosuge, Tomoo.
In: Human Pathology, Vol. 28, No. 9, 1997, p. 1010-1017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intraductal papillary tumors and mucinous cystic tumors of the pancreas
T2 - Clinicopathologic study of 38 cases
AU - Fukushima, Noriyoshi
AU - Mukai, Kiyoshi
AU - Kanai, Yae
AU - Hasebe, Takahiro
AU - Shimada, Kazuaki
AU - Ozaki, Hideo
AU - Kinoshita, Taira
AU - Kosuge, Tomoo
PY - 1997
Y1 - 1997
N2 - Clinicopathological features of 28 patients with intraductal papillary tumor (IDPT) and 10 patients with mucinous cystic tumor (MCT) of the pancreas were studied. Both IDPT and MCT showed papillary projections of the epithelium with abundant mucus secretion in the ectatic ducts or cystic spaces. The patients with IDPT comprised 19 men and 9 women with a mean age of 64.9 years. Three fourths of the IDPTs were located in the pancreatic head, and the mean tumor size was 9.5 cm. Local recurrence was observed in one patient, but none died of IDPT. In contrasts all patients with MCT were women, with a mean age of 49.4 years. None of the MCTs arose in the head, and the mean tumor size was 7.1 cm. One patient died of MCT, but all of the others survived without recurrence. Eight IDPTs and three MCTs showed invasion into the surrounding pancreatic tissue. Muconodular infiltration was mainly observed in five IDPTs and one MCTs and tubular infiltration in three IDPTs and two MCTs. A characteristic histological finding associated with the muconodular infiltration in IDPT was subepithelial 'mucin droplets' that appeared to represent a change in polarity of mucus secretion. The formation of such subepithelial 'mucin droplets' may he the initial step of muconodular infiltration in IDPT. Muconodular infiltration in IDPT appears different morphologically and biologically from the mucinous carcinoma subtype of conventional invasive ductal carcinorma.
AB - Clinicopathological features of 28 patients with intraductal papillary tumor (IDPT) and 10 patients with mucinous cystic tumor (MCT) of the pancreas were studied. Both IDPT and MCT showed papillary projections of the epithelium with abundant mucus secretion in the ectatic ducts or cystic spaces. The patients with IDPT comprised 19 men and 9 women with a mean age of 64.9 years. Three fourths of the IDPTs were located in the pancreatic head, and the mean tumor size was 9.5 cm. Local recurrence was observed in one patient, but none died of IDPT. In contrasts all patients with MCT were women, with a mean age of 49.4 years. None of the MCTs arose in the head, and the mean tumor size was 7.1 cm. One patient died of MCT, but all of the others survived without recurrence. Eight IDPTs and three MCTs showed invasion into the surrounding pancreatic tissue. Muconodular infiltration was mainly observed in five IDPTs and one MCTs and tubular infiltration in three IDPTs and two MCTs. A characteristic histological finding associated with the muconodular infiltration in IDPT was subepithelial 'mucin droplets' that appeared to represent a change in polarity of mucus secretion. The formation of such subepithelial 'mucin droplets' may he the initial step of muconodular infiltration in IDPT. Muconodular infiltration in IDPT appears different morphologically and biologically from the mucinous carcinoma subtype of conventional invasive ductal carcinorma.
KW - Intraductal papillary tumor
KW - Mucinous cystic tumor
KW - Muconodular infiltration
KW - Pancreatic tumor
KW - Tubular infiltration
UR - http://www.scopus.com/inward/record.url?scp=0030886967&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030886967&partnerID=8YFLogxK
U2 - 10.1016/S0046-8177(97)90053-8
DO - 10.1016/S0046-8177(97)90053-8
M3 - Article
C2 - 9308724
AN - SCOPUS:0030886967
VL - 28
SP - 1010
EP - 1017
JO - Human Pathology
JF - Human Pathology
SN - 0046-8177
IS - 9
ER -