Intrahepatic cholangiocarcinoma arising 33 years after excision of a choledochal cyst

Report of a case

Ryo Nishiyama, Masahiro Shinoda, Minoru Tanabe, Yohei Masugi, Akihisa Ueno, Taizo Hibi, Kiminori Takano, Hiroto Fujisaki, Minoru Kitago, Osamu Itano, Shigeyuki Kawachi, Koichi Aiura, Akihiro Tanimoto, Michiie Sakamaoto, Yuukou Kitagawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We report a case of intrahepatic cholangiocarcinoma arising 33 years after excision of a choledochal cyst. A 61-year-old woman was admitted to our hospital complaining of fever. Thirty-three years ago she had undergone extrahepatic choledochal cystectomy and choledochojejunostomy for a choledochal cyst. Computed tomography showed a tumor in the anterior segment of the liver, extending to the posterior and medial segments and the right portal vein. Intrahepatic biliary stones were seen in the bile ducts. We performed extended right lobectomy. Microscopically, the tumor was cholangiocarcinoma. Most of the tumor area was composed of invasive adenocarcinoma but a carcinoma-in-situ component was also observed in some regions including the hilar bile duct, where an intrahepatic biliary stone was seen. This suggests that the cancer development could be related to intrahepatic cholestasis. Patients with choledochal cyst may have to be carefully followed up for more than 30 years even after diversion surgery.

Original languageEnglish
Pages (from-to)320-325
Number of pages6
JournalInternational Surgery
Volume96
Issue number4
DOIs
Publication statusPublished - 2011 Oct

Fingerprint

Choledochal Cyst
Cholangiocarcinoma
Neoplasms
Choledochostomy
Intrahepatic Cholestasis
Intrahepatic Bile Ducts
Cystectomy
Carcinoma in Situ
Portal Vein
Bile Ducts
Adenocarcinoma
Fever
Tomography
Liver

Keywords

  • Cancer development
  • Cholangiocarcinoma
  • Choledochal cyst

ASJC Scopus subject areas

  • Surgery

Cite this

Intrahepatic cholangiocarcinoma arising 33 years after excision of a choledochal cyst : Report of a case. / Nishiyama, Ryo; Shinoda, Masahiro; Tanabe, Minoru; Masugi, Yohei; Ueno, Akihisa; Hibi, Taizo; Takano, Kiminori; Fujisaki, Hiroto; Kitago, Minoru; Itano, Osamu; Kawachi, Shigeyuki; Aiura, Koichi; Tanimoto, Akihiro; Sakamaoto, Michiie; Kitagawa, Yuukou.

In: International Surgery, Vol. 96, No. 4, 10.2011, p. 320-325.

Research output: Contribution to journalArticle

Nishiyama, Ryo ; Shinoda, Masahiro ; Tanabe, Minoru ; Masugi, Yohei ; Ueno, Akihisa ; Hibi, Taizo ; Takano, Kiminori ; Fujisaki, Hiroto ; Kitago, Minoru ; Itano, Osamu ; Kawachi, Shigeyuki ; Aiura, Koichi ; Tanimoto, Akihiro ; Sakamaoto, Michiie ; Kitagawa, Yuukou. / Intrahepatic cholangiocarcinoma arising 33 years after excision of a choledochal cyst : Report of a case. In: International Surgery. 2011 ; Vol. 96, No. 4. pp. 320-325.
@article{2abd2edcf31d482f8ee21728b8508743,
title = "Intrahepatic cholangiocarcinoma arising 33 years after excision of a choledochal cyst: Report of a case",
abstract = "We report a case of intrahepatic cholangiocarcinoma arising 33 years after excision of a choledochal cyst. A 61-year-old woman was admitted to our hospital complaining of fever. Thirty-three years ago she had undergone extrahepatic choledochal cystectomy and choledochojejunostomy for a choledochal cyst. Computed tomography showed a tumor in the anterior segment of the liver, extending to the posterior and medial segments and the right portal vein. Intrahepatic biliary stones were seen in the bile ducts. We performed extended right lobectomy. Microscopically, the tumor was cholangiocarcinoma. Most of the tumor area was composed of invasive adenocarcinoma but a carcinoma-in-situ component was also observed in some regions including the hilar bile duct, where an intrahepatic biliary stone was seen. This suggests that the cancer development could be related to intrahepatic cholestasis. Patients with choledochal cyst may have to be carefully followed up for more than 30 years even after diversion surgery.",
keywords = "Cancer development, Cholangiocarcinoma, Choledochal cyst",
author = "Ryo Nishiyama and Masahiro Shinoda and Minoru Tanabe and Yohei Masugi and Akihisa Ueno and Taizo Hibi and Kiminori Takano and Hiroto Fujisaki and Minoru Kitago and Osamu Itano and Shigeyuki Kawachi and Koichi Aiura and Akihiro Tanimoto and Michiie Sakamaoto and Yuukou Kitagawa",
year = "2011",
month = "10",
doi = "10.9738/CC82.1",
language = "English",
volume = "96",
pages = "320--325",
journal = "International Surgery",
issn = "0020-8868",
publisher = "International College of Surgeons",
number = "4",

}

TY - JOUR

T1 - Intrahepatic cholangiocarcinoma arising 33 years after excision of a choledochal cyst

T2 - Report of a case

AU - Nishiyama, Ryo

AU - Shinoda, Masahiro

AU - Tanabe, Minoru

AU - Masugi, Yohei

AU - Ueno, Akihisa

AU - Hibi, Taizo

AU - Takano, Kiminori

AU - Fujisaki, Hiroto

AU - Kitago, Minoru

AU - Itano, Osamu

AU - Kawachi, Shigeyuki

AU - Aiura, Koichi

AU - Tanimoto, Akihiro

AU - Sakamaoto, Michiie

AU - Kitagawa, Yuukou

PY - 2011/10

Y1 - 2011/10

N2 - We report a case of intrahepatic cholangiocarcinoma arising 33 years after excision of a choledochal cyst. A 61-year-old woman was admitted to our hospital complaining of fever. Thirty-three years ago she had undergone extrahepatic choledochal cystectomy and choledochojejunostomy for a choledochal cyst. Computed tomography showed a tumor in the anterior segment of the liver, extending to the posterior and medial segments and the right portal vein. Intrahepatic biliary stones were seen in the bile ducts. We performed extended right lobectomy. Microscopically, the tumor was cholangiocarcinoma. Most of the tumor area was composed of invasive adenocarcinoma but a carcinoma-in-situ component was also observed in some regions including the hilar bile duct, where an intrahepatic biliary stone was seen. This suggests that the cancer development could be related to intrahepatic cholestasis. Patients with choledochal cyst may have to be carefully followed up for more than 30 years even after diversion surgery.

AB - We report a case of intrahepatic cholangiocarcinoma arising 33 years after excision of a choledochal cyst. A 61-year-old woman was admitted to our hospital complaining of fever. Thirty-three years ago she had undergone extrahepatic choledochal cystectomy and choledochojejunostomy for a choledochal cyst. Computed tomography showed a tumor in the anterior segment of the liver, extending to the posterior and medial segments and the right portal vein. Intrahepatic biliary stones were seen in the bile ducts. We performed extended right lobectomy. Microscopically, the tumor was cholangiocarcinoma. Most of the tumor area was composed of invasive adenocarcinoma but a carcinoma-in-situ component was also observed in some regions including the hilar bile duct, where an intrahepatic biliary stone was seen. This suggests that the cancer development could be related to intrahepatic cholestasis. Patients with choledochal cyst may have to be carefully followed up for more than 30 years even after diversion surgery.

KW - Cancer development

KW - Cholangiocarcinoma

KW - Choledochal cyst

UR - http://www.scopus.com/inward/record.url?scp=84864540757&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864540757&partnerID=8YFLogxK

U2 - 10.9738/CC82.1

DO - 10.9738/CC82.1

M3 - Article

VL - 96

SP - 320

EP - 325

JO - International Surgery

JF - International Surgery

SN - 0020-8868

IS - 4

ER -