Intrahepatic Cholangiocarcinoma Presenting Intrabile Duct Extension: Clinicopathologic Study of Five Resected Cases

Junji Yamamoto, Tomoo Kosuge, Tadatoshi Takayama, Kazuaki Shimada, Susumu Yamasaki, Michiie Sakamoto, Setsuo Hirohashi, Masatoshi Makuuchi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Intrahepatic cholangiocarcinoma, which is ordinarily a very invasive tumor and often takes a rapid and fatal course, sometimes shows macroscopic intrabile duct extension. The purpose of this study is to illustrate the clinicopathologic features of this variant of intrahepatic cholangiocarcinoma, which has occasionally been reported. Five cases of the tumor with gross extension to the bile duct lumen were studied to determine their clinical and pathologic features. The tumor showed intrabile duct growth and superficial mucosal spread in two patients. In two other patients, an apparent mass lesion accompanied the intraluminal component. In the remaining patient, a polypoid tumor infiltrated the portal tract of the left lateral segment, where it had arisen. Microscopic examination did not reveal any vascular involvement or intrahepatic or lymph node metastasis. All of the patients are alive without recurrence, except for Patient I who died 7 years and 7 months after surgery from a rapidly growing tumor in the liver remnant. Intrabile duct growth of intrahepatic cholangiocarcinoma may reflect indolent biological behavior and thus warrants an aggressive surgical approach, which appears to give a good prognosis.

Original languageEnglish
Pages (from-to)18-21
Number of pages4
JournalJapanese Journal of Clinical Oncology
Volume27
Issue number1
Publication statusPublished - 1997
Externally publishedYes

Fingerprint

Cholangiocarcinoma
Neoplasms
Growth
Bile Ducts
Blood Vessels
Lymph Nodes
Neoplasm Metastasis
Recurrence
Liver

Keywords

  • Intrabile duct extension - Surgery -prognosis - Pathology
  • Intrahepatic cholangiocarcinoma

ASJC Scopus subject areas

  • Oncology

Cite this

Intrahepatic Cholangiocarcinoma Presenting Intrabile Duct Extension : Clinicopathologic Study of Five Resected Cases. / Yamamoto, Junji; Kosuge, Tomoo; Takayama, Tadatoshi; Shimada, Kazuaki; Yamasaki, Susumu; Sakamoto, Michiie; Hirohashi, Setsuo; Makuuchi, Masatoshi.

In: Japanese Journal of Clinical Oncology, Vol. 27, No. 1, 1997, p. 18-21.

Research output: Contribution to journalArticle

Yamamoto, J, Kosuge, T, Takayama, T, Shimada, K, Yamasaki, S, Sakamoto, M, Hirohashi, S & Makuuchi, M 1997, 'Intrahepatic Cholangiocarcinoma Presenting Intrabile Duct Extension: Clinicopathologic Study of Five Resected Cases', Japanese Journal of Clinical Oncology, vol. 27, no. 1, pp. 18-21.
Yamamoto, Junji ; Kosuge, Tomoo ; Takayama, Tadatoshi ; Shimada, Kazuaki ; Yamasaki, Susumu ; Sakamoto, Michiie ; Hirohashi, Setsuo ; Makuuchi, Masatoshi. / Intrahepatic Cholangiocarcinoma Presenting Intrabile Duct Extension : Clinicopathologic Study of Five Resected Cases. In: Japanese Journal of Clinical Oncology. 1997 ; Vol. 27, No. 1. pp. 18-21.
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