Intrahepatic cholangiocarcinoma with old infestation of Schistosoma japonicum: Report of a case

Tomotaka Akatsu, Motohide Shimazu, Masahiro Shinoda, Shigeyuki Kawachi, Minoru Tanabe, Koichi Aiura, Masakazu Ueda, Kaori Kameyama, Michiie Sakamoto, Masaki Kitajima, Yuukou Kitagawa

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Abstract

We report a rare case of intrahepatic cholangiocarcinoma associated with old infestation of Schistosoma japonicum. The patient was a 76-year-old Japanese man who had lived his childhood in an endemic area of this parasite. He presented with jaundice and computed tomography showed a 4-cm, hypodense tumor in segment VIII of the liver. Microscopically, the resected mass was composed of well-differentiated adenocarcinoma cells. Fibrosis and inflammation were seen around the dilated peripheral portal veins embolized with dead S. japonicum eggs. Our search of the literature found only one other case of cholangiocarcinoma coincident with S. japonicum, suggesting that it is not a risk factor for cholangiocarcinoma, although the inflammation and fibrosis caused by the S. japonicum eggshells may predispose to carcinogenesis. However, there is no evidence supporting this hypothesis. More data are necessary to evaluate the differences in clinicopathological findings between cholangiocarcinoma concomitant with S. japonicum and the usual type of cholangiocarcinoma.

Original languageEnglish
Pages (from-to)905-909
Number of pages5
JournalSurgery Today
Volume37
Issue number10
DOIs
Publication statusPublished - 2007 Oct

Fingerprint

Schistosoma japonicum
Cholangiocarcinoma
Fibrosis
Egg Shell
Inflammation
Portal Vein
Jaundice
Eggs
Carcinogenesis
Parasites
Adenocarcinoma
Tomography
Liver
Neoplasms

Keywords

  • Cholangiocarcinoma
  • Infestation
  • Parasite
  • Schistosoma japonicum

ASJC Scopus subject areas

  • Surgery

Cite this

Intrahepatic cholangiocarcinoma with old infestation of Schistosoma japonicum : Report of a case. / Akatsu, Tomotaka; Shimazu, Motohide; Shinoda, Masahiro; Kawachi, Shigeyuki; Tanabe, Minoru; Aiura, Koichi; Ueda, Masakazu; Kameyama, Kaori; Sakamoto, Michiie; Kitajima, Masaki; Kitagawa, Yuukou.

In: Surgery Today, Vol. 37, No. 10, 10.2007, p. 905-909.

Research output: Contribution to journalArticle

Akatsu, Tomotaka ; Shimazu, Motohide ; Shinoda, Masahiro ; Kawachi, Shigeyuki ; Tanabe, Minoru ; Aiura, Koichi ; Ueda, Masakazu ; Kameyama, Kaori ; Sakamoto, Michiie ; Kitajima, Masaki ; Kitagawa, Yuukou. / Intrahepatic cholangiocarcinoma with old infestation of Schistosoma japonicum : Report of a case. In: Surgery Today. 2007 ; Vol. 37, No. 10. pp. 905-909.
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