Intraoperative intrapleural hypotonic cisplatin treatment for carcinomatous pleuritis

Yukito Ichinose, Tokujiro Yano, Hiroshi Asoh, Hideki Yokoyama, Yasuro Fukuyama, Jun Miyagi, Shinji Kuninaka, Yasuhiro Terazaki

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17 Citations (Scopus)

Abstract

Background and Objectives: We recently developed a new intraoperatire intrapleural hypotonic cisplatin treatment for carcinomatous pleuritis found at thoracotomy in non-small cell lung cancer patients. In the present study, the efficacy and adverse events of this treatment as well as the pharmacokinetics of cisplatin in the blood after the treatment were evaluated. Patients and Methods: Twenty-one patients received the treatment for 15 minutes after completing the intrathoracic surgical procedures. The total and free platinum levels in the blood of five patients were then measured. As a control, 29 patients without such treatment were reviewed retrospectively. Results: The survival rates in the treatment and non- treatment groups were similar. The pleural disease free survival of the treated patients was, however, significantly higher than that of the non- treated patients. Such pleural disease as effusion and the growth of the pleural disseminated tumors only appeared in three of the 21 (14%) treated patients while 26 of 29 (90%) non-treated patients had clinically detected pleural disease. The blood platinum levels after the treatment were extremely low and such low levels probably induced no systemic adverse events after the treatment. The only adverse event of this treatment was an increase in the postoperative drainage volume. Conclusions: These observations seem to suggest that intraoperative intrapleural hypotonic cisplatin treatment for carcinomatous pleuritis found at thoracotomy can, at least, delay the appearance of the pleural disease without any adverse events.

Original languageEnglish
Pages (from-to)196-200
Number of pages5
JournalJournal of Surgical Oncology
Volume66
Issue number3
DOIs
Publication statusPublished - 1997 Nov 1

Keywords

  • Carcinomatous pleuritis
  • Cisplatin
  • Intracavitary chemotherapy
  • Malignant effusion
  • Non-small cell lung cancer

ASJC Scopus subject areas

  • Surgery
  • Oncology

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    Ichinose, Y., Yano, T., Asoh, H., Yokoyama, H., Fukuyama, Y., Miyagi, J., Kuninaka, S., & Terazaki, Y. (1997). Intraoperative intrapleural hypotonic cisplatin treatment for carcinomatous pleuritis. Journal of Surgical Oncology, 66(3), 196-200. https://doi.org/10.1002/(SICI)1096-9098(199711)66:3<196::AID-JSO8>3.0.CO;2-7