Intrarenal satellites of renal cell carcinoma: Histopathologic manifestation and clinical implication

Mototsugu Oya, Kaoru Nakamura, Shiro Baba, Jun Ichi Hata, Hiroshi Tazaki

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43 Citations (Scopus)

Abstract

Objectives: This study was designed to gain more insight into the incidence of satellites of renal cell carcinoma related to the pathologic stage and grade of the primary tumor. Methods: One hundred eight nephrectomized kidneys with renal cell carcinoma were sectioned at 3-mm intervals and inspected microscopically for satellite carcinomas. The number, site, size, and distance of satellite carcinomas found were recorded in relation to the primary carcinoma. Results: The overall incidence of satellite carcinoma was 6.5% (7 of 108). The incidence of satellite carcinoma in relation to the pathologic staging of the primary tumor was 7.1 % (1 of 14) in pT1, 3.0% (2 of 66) in pT2, and 14.3% (4 of 28) in pT3. The incidence was higher in patients with N1 disease (25%) than in those with NO (5.0%), and higher in M1 disease (25%) than in those in MO (5.77%). There was no relationship between the grade and multicentricity. Conclusions: The incidence of satellite carcinoma was higher in cases with high-stage primary carcinoma. However, even in localized diseases (pT1, pT2), satellite carcinomas were found at a 3.75% incidence. When nephron-sparing surgery is indicated in low-stage cases, precise clinical staging using a combination of various imaging modalities is mandatory, with intraoperative ultrasonography being one possible modality for detecting a concomitant satellite carcinoma.

Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalUrology
Volume46
Issue number2
DOIs
Publication statusPublished - 1995

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Renal Cell Carcinoma
Carcinoma
Incidence
Neoplasm Staging
Nephrons
Ultrasonography
Kidney

ASJC Scopus subject areas

  • Urology

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Intrarenal satellites of renal cell carcinoma : Histopathologic manifestation and clinical implication. / Oya, Mototsugu; Nakamura, Kaoru; Baba, Shiro; Hata, Jun Ichi; Tazaki, Hiroshi.

In: Urology, Vol. 46, No. 2, 1995, p. 161-164.

Research output: Contribution to journalArticle

Oya, Mototsugu ; Nakamura, Kaoru ; Baba, Shiro ; Hata, Jun Ichi ; Tazaki, Hiroshi. / Intrarenal satellites of renal cell carcinoma : Histopathologic manifestation and clinical implication. In: Urology. 1995 ; Vol. 46, No. 2. pp. 161-164.
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abstract = "Objectives: This study was designed to gain more insight into the incidence of satellites of renal cell carcinoma related to the pathologic stage and grade of the primary tumor. Methods: One hundred eight nephrectomized kidneys with renal cell carcinoma were sectioned at 3-mm intervals and inspected microscopically for satellite carcinomas. The number, site, size, and distance of satellite carcinomas found were recorded in relation to the primary carcinoma. Results: The overall incidence of satellite carcinoma was 6.5{\%} (7 of 108). The incidence of satellite carcinoma in relation to the pathologic staging of the primary tumor was 7.1 {\%} (1 of 14) in pT1, 3.0{\%} (2 of 66) in pT2, and 14.3{\%} (4 of 28) in pT3. The incidence was higher in patients with N1 disease (25{\%}) than in those with NO (5.0{\%}), and higher in M1 disease (25{\%}) than in those in MO (5.77{\%}). There was no relationship between the grade and multicentricity. Conclusions: The incidence of satellite carcinoma was higher in cases with high-stage primary carcinoma. However, even in localized diseases (pT1, pT2), satellite carcinomas were found at a 3.75{\%} incidence. When nephron-sparing surgery is indicated in low-stage cases, precise clinical staging using a combination of various imaging modalities is mandatory, with intraoperative ultrasonography being one possible modality for detecting a concomitant satellite carcinoma.",
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