Intravascular large B-cell lymphoma involving large blood vessels, three autopsy cases

Shuku Sato; Shinichi Teshima; Naoya Nakamura; Takayasu Ohtake; Jun Kikuchi; Hirohisa Kishi; Kyoichi Nomura; Nozomu Kurose; Yasufumi Masaki; Jun ichi Tamaru

doi:10.1111/pin.12751

Intravascular large B-cell lymphoma involving large blood vessels, three autopsy cases

Shuku Sato, Shinichi Teshima, Naoya Nakamura, Takayasu Ohtake, Jun Kikuchi, Hirohisa Kishi, Kyoichi Nomura, Nozomu Kurose, Yasufumi Masaki, Jun ichi Tamaru

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Although intravascular large B-cell lymphoma (IVLBCL) is an extranodal lymphoma characterized by the selective growth of lymphoma cells within the lumina of small vessels, we here report three autopsy cases of IVLBCL characterized by the proliferation within large blood vessels. These three cases were diagnosed as IVLBCL of the bone marrow or skin biopsy. Two cases died suddenly before treatment, whereas the other died during treatment. Autopsies showed a large embolus of dense lymphoma cells extending from the truncus pulmonalis to the pulmonary arteries in Case 1, emboli of lymphoma cells in the aorta and carotis in Case 2, and a mass of lymphoma cells blocking the lumen of the aortic arch in Case 3. This is the first report of IVLBCL involving large blood vessels, and it is essential to note that this type of IVLBCL might cause sudden death because of tumor emboli within large blood vessels.

Original language	English
Pages (from-to)	97-103
Number of pages	7
Journal	Pathology international
Volume	69
Issue number	2
DOIs	https://doi.org/10.1111/pin.12751
Publication status	Published - 2019 Feb 1
Externally published	Yes

Keywords

intravascular large B-cell lymphoma
large blood vessel
sudden death
tumor embolism

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1111/pin.12751

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title = "Intravascular large B-cell lymphoma involving large blood vessels, three autopsy cases",

abstract = "Although intravascular large B-cell lymphoma (IVLBCL) is an extranodal lymphoma characterized by the selective growth of lymphoma cells within the lumina of small vessels, we here report three autopsy cases of IVLBCL characterized by the proliferation within large blood vessels. These three cases were diagnosed as IVLBCL of the bone marrow or skin biopsy. Two cases died suddenly before treatment, whereas the other died during treatment. Autopsies showed a large embolus of dense lymphoma cells extending from the truncus pulmonalis to the pulmonary arteries in Case 1, emboli of lymphoma cells in the aorta and carotis in Case 2, and a mass of lymphoma cells blocking the lumen of the aortic arch in Case 3. This is the first report of IVLBCL involving large blood vessels, and it is essential to note that this type of IVLBCL might cause sudden death because of tumor emboli within large blood vessels.",

keywords = "intravascular large B-cell lymphoma, large blood vessel, sudden death, tumor embolism",

author = "Shuku Sato and Shinichi Teshima and Naoya Nakamura and Takayasu Ohtake and Jun Kikuchi and Hirohisa Kishi and Kyoichi Nomura and Nozomu Kurose and Yasufumi Masaki and Tamaru, {Jun ichi}",

year = "2019",

month = feb,

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doi = "10.1111/pin.12751",

language = "English",

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T1 - Intravascular large B-cell lymphoma involving large blood vessels, three autopsy cases

AU - Sato, Shuku

AU - Teshima, Shinichi

AU - Nakamura, Naoya

AU - Ohtake, Takayasu

AU - Kikuchi, Jun

AU - Kishi, Hirohisa

AU - Nomura, Kyoichi

AU - Kurose, Nozomu

AU - Masaki, Yasufumi

AU - Tamaru, Jun ichi

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Although intravascular large B-cell lymphoma (IVLBCL) is an extranodal lymphoma characterized by the selective growth of lymphoma cells within the lumina of small vessels, we here report three autopsy cases of IVLBCL characterized by the proliferation within large blood vessels. These three cases were diagnosed as IVLBCL of the bone marrow or skin biopsy. Two cases died suddenly before treatment, whereas the other died during treatment. Autopsies showed a large embolus of dense lymphoma cells extending from the truncus pulmonalis to the pulmonary arteries in Case 1, emboli of lymphoma cells in the aorta and carotis in Case 2, and a mass of lymphoma cells blocking the lumen of the aortic arch in Case 3. This is the first report of IVLBCL involving large blood vessels, and it is essential to note that this type of IVLBCL might cause sudden death because of tumor emboli within large blood vessels.

AB - Although intravascular large B-cell lymphoma (IVLBCL) is an extranodal lymphoma characterized by the selective growth of lymphoma cells within the lumina of small vessels, we here report three autopsy cases of IVLBCL characterized by the proliferation within large blood vessels. These three cases were diagnosed as IVLBCL of the bone marrow or skin biopsy. Two cases died suddenly before treatment, whereas the other died during treatment. Autopsies showed a large embolus of dense lymphoma cells extending from the truncus pulmonalis to the pulmonary arteries in Case 1, emboli of lymphoma cells in the aorta and carotis in Case 2, and a mass of lymphoma cells blocking the lumen of the aortic arch in Case 3. This is the first report of IVLBCL involving large blood vessels, and it is essential to note that this type of IVLBCL might cause sudden death because of tumor emboli within large blood vessels.

KW - intravascular large B-cell lymphoma

KW - large blood vessel

KW - sudden death

KW - tumor embolism

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ER -

Intravascular large B-cell lymphoma involving large blood vessels, three autopsy cases

Abstract

Keywords

ASJC Scopus subject areas

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