Intravenous cyclophosphamide was effective in a case of recurrent optic disc vasculitis

Purpose : To report a case of recurrent optic disc vasculitis that responded to intravenous cyclophosphamide. Case : A 35-year-old female present with impaired visual acuity in the right eye since one month before. She had been diagnosed with aplastic anemia at the age of 2 years and been receiving cyclosporine. Findings : Corrected visual acuity was 0.6 right and 1.2 left. The right eye showed swollen optic disc and was diagnosed with optic disc vasculitis. Spontaneous recovery set in after 2 weeks. Visual acuity in the left eye decreased to 0.07 3 months later. The left eye showed pale optic disc and was diagnosed with neuroretinitis and retinal vasculitis. Another 3 months later, the right eye showed recurrence of optic disc vasculitis. Visual acuity improved after systemic corticosteroid but declined after tapering or withdrawal. Intravenous cyclophosphamide was performed 14 times. Findings in both eyes stabilized with visual acuity of 1.0 right and 0.3 left 35 weeks after onset. Conclusion : The present case illustrates that systemic cyclophosphamide may be effective for optic disc vasculitis dependent on corticosteroid.