Intravital observation on the endothelin-induced hemodynamic changes in rat intestinal microvascular beds

I. Kurose, S. Miura, D. Fukumura, M. Suematsu, E. Sekizuka, H. Tashiro, H. Serizawa, M. Tsuchiya

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The influence of local intravital administration of endothelin-1 on microvessels of rat small intestine was investigated by laser-doppler flowmetry and by intravital microscopy. Changes in vascular diameter and red blood cell velocity in microvascular beds were determined by using a high-speed video camera system. Endothelin-1 at concentrations in the 100 pmol/kg to 1 nmol/kg range caused the vasoconstriction of arterioles in a dose-dependent manner, and the constrictive actions were dominant especially in the terminal arteriole (3A). A decrease in red blood cell velocity was observed with the endothelin-induced arteriolar constriction, and was followed by mucosal ischemia. The present study also revealed that endothelin-1 is more potent as a constrictor on arteriolar than on venular smooth muscle. These results indicate that endothelin-1 is a potent vasoconstrictive peptide in microvessels of rat intestine and suggest that endothelin may participate as a modulator in the regulation of intestinal mucosal blood flow under physiologic conditions.

Original languageEnglish
Pages (from-to)55-60
Number of pages6
JournalJournal of Vascular Medicine and Biology
Volume3
Issue number2
Publication statusPublished - 1991

Fingerprint

Endothelins
Endothelin-1
Hemodynamics
Arterioles
Microvessels
Erythrocytes
Laser-Doppler Flowmetry
Vasoconstriction
Constriction
Small Intestine
Intestines
Smooth Muscle
Blood Vessels
Ischemia
Peptides

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Kurose, I., Miura, S., Fukumura, D., Suematsu, M., Sekizuka, E., Tashiro, H., ... Tsuchiya, M. (1991). Intravital observation on the endothelin-induced hemodynamic changes in rat intestinal microvascular beds. Journal of Vascular Medicine and Biology, 3(2), 55-60.

Intravital observation on the endothelin-induced hemodynamic changes in rat intestinal microvascular beds. / Kurose, I.; Miura, S.; Fukumura, D.; Suematsu, M.; Sekizuka, E.; Tashiro, H.; Serizawa, H.; Tsuchiya, M.

In: Journal of Vascular Medicine and Biology, Vol. 3, No. 2, 1991, p. 55-60.

Research output: Contribution to journalArticle

Kurose, I, Miura, S, Fukumura, D, Suematsu, M, Sekizuka, E, Tashiro, H, Serizawa, H & Tsuchiya, M 1991, 'Intravital observation on the endothelin-induced hemodynamic changes in rat intestinal microvascular beds', Journal of Vascular Medicine and Biology, vol. 3, no. 2, pp. 55-60.
Kurose, I. ; Miura, S. ; Fukumura, D. ; Suematsu, M. ; Sekizuka, E. ; Tashiro, H. ; Serizawa, H. ; Tsuchiya, M. / Intravital observation on the endothelin-induced hemodynamic changes in rat intestinal microvascular beds. In: Journal of Vascular Medicine and Biology. 1991 ; Vol. 3, No. 2. pp. 55-60.
@article{2474591a68714358a798dc51c6b1e126,
title = "Intravital observation on the endothelin-induced hemodynamic changes in rat intestinal microvascular beds",
abstract = "The influence of local intravital administration of endothelin-1 on microvessels of rat small intestine was investigated by laser-doppler flowmetry and by intravital microscopy. Changes in vascular diameter and red blood cell velocity in microvascular beds were determined by using a high-speed video camera system. Endothelin-1 at concentrations in the 100 pmol/kg to 1 nmol/kg range caused the vasoconstriction of arterioles in a dose-dependent manner, and the constrictive actions were dominant especially in the terminal arteriole (3A). A decrease in red blood cell velocity was observed with the endothelin-induced arteriolar constriction, and was followed by mucosal ischemia. The present study also revealed that endothelin-1 is more potent as a constrictor on arteriolar than on venular smooth muscle. These results indicate that endothelin-1 is a potent vasoconstrictive peptide in microvessels of rat intestine and suggest that endothelin may participate as a modulator in the regulation of intestinal mucosal blood flow under physiologic conditions.",
author = "I. Kurose and S. Miura and D. Fukumura and M. Suematsu and E. Sekizuka and H. Tashiro and H. Serizawa and M. Tsuchiya",
year = "1991",
language = "English",
volume = "3",
pages = "55--60",
journal = "Journal of Vascular Medicine and Biology",
issn = "1042-5268",
number = "2",

}

TY - JOUR

T1 - Intravital observation on the endothelin-induced hemodynamic changes in rat intestinal microvascular beds

AU - Kurose, I.

AU - Miura, S.

AU - Fukumura, D.

AU - Suematsu, M.

AU - Sekizuka, E.

AU - Tashiro, H.

AU - Serizawa, H.

AU - Tsuchiya, M.

PY - 1991

Y1 - 1991

N2 - The influence of local intravital administration of endothelin-1 on microvessels of rat small intestine was investigated by laser-doppler flowmetry and by intravital microscopy. Changes in vascular diameter and red blood cell velocity in microvascular beds were determined by using a high-speed video camera system. Endothelin-1 at concentrations in the 100 pmol/kg to 1 nmol/kg range caused the vasoconstriction of arterioles in a dose-dependent manner, and the constrictive actions were dominant especially in the terminal arteriole (3A). A decrease in red blood cell velocity was observed with the endothelin-induced arteriolar constriction, and was followed by mucosal ischemia. The present study also revealed that endothelin-1 is more potent as a constrictor on arteriolar than on venular smooth muscle. These results indicate that endothelin-1 is a potent vasoconstrictive peptide in microvessels of rat intestine and suggest that endothelin may participate as a modulator in the regulation of intestinal mucosal blood flow under physiologic conditions.

AB - The influence of local intravital administration of endothelin-1 on microvessels of rat small intestine was investigated by laser-doppler flowmetry and by intravital microscopy. Changes in vascular diameter and red blood cell velocity in microvascular beds were determined by using a high-speed video camera system. Endothelin-1 at concentrations in the 100 pmol/kg to 1 nmol/kg range caused the vasoconstriction of arterioles in a dose-dependent manner, and the constrictive actions were dominant especially in the terminal arteriole (3A). A decrease in red blood cell velocity was observed with the endothelin-induced arteriolar constriction, and was followed by mucosal ischemia. The present study also revealed that endothelin-1 is more potent as a constrictor on arteriolar than on venular smooth muscle. These results indicate that endothelin-1 is a potent vasoconstrictive peptide in microvessels of rat intestine and suggest that endothelin may participate as a modulator in the regulation of intestinal mucosal blood flow under physiologic conditions.

UR - http://www.scopus.com/inward/record.url?scp=0026344877&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026344877&partnerID=8YFLogxK

M3 - Article

VL - 3

SP - 55

EP - 60

JO - Journal of Vascular Medicine and Biology

JF - Journal of Vascular Medicine and Biology

SN - 1042-5268

IS - 2

ER -