Inubosins A, B, and C are acridine alkaloids isolated from a culture of streptomyces sp. IFM 11440 with Ngn2 promoter activity

Midori A. Arai, Kazune Koryudzu, Masami Ishibashi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Three new acridine alkaloids, inubosins A (1), B (2), and C (3), were isolated from an extract of a culture of Streptomyces sp. IFM 11440 using bioassay-guided fractionation. Neurogenin2 (Ngn2) is an activator-type basic helix-loop-helix transcription factor that promotes neural stem cell differentiation. Using cell-based Ngn2 promoter activity-guided screening, Streptomyces sp. IFM 11440 was found to induce Ngn2 promoter activity. The structures of 1-3 were established using spectroscopic methods, including 1D- and 2D-NMR measurements. Inubosin B (2) showed potent Ngn2 promoter activity. Moreover, inubosin B (2) increased mRNA expression of genes related to neural stem cell differentiation.

Original languageEnglish
Pages (from-to)311-314
Number of pages4
JournalJournal of Natural Products
Volume78
Issue number2
DOIs
Publication statusPublished - 2015 Feb 27
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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