Inubosins A, B, and C are acridine alkaloids isolated from a culture of streptomyces sp. IFM 11440 with Ngn2 promoter activity

Midori A. Arai; Kazune Koryudzu; Masami Ishibashi

doi:10.1021/np5006218

Inubosins A, B, and C are acridine alkaloids isolated from a culture of streptomyces sp. IFM 11440 with Ngn2 promoter activity

Midori A. Arai, Kazune Koryudzu, Masami Ishibashi

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Three new acridine alkaloids, inubosins A (1), B (2), and C (3), were isolated from an extract of a culture of Streptomyces sp. IFM 11440 using bioassay-guided fractionation. Neurogenin2 (Ngn2) is an activator-type basic helix-loop-helix transcription factor that promotes neural stem cell differentiation. Using cell-based Ngn2 promoter activity-guided screening, Streptomyces sp. IFM 11440 was found to induce Ngn2 promoter activity. The structures of 1-3 were established using spectroscopic methods, including 1D- and 2D-NMR measurements. Inubosin B (2) showed potent Ngn2 promoter activity. Moreover, inubosin B (2) increased mRNA expression of genes related to neural stem cell differentiation.

Original language	English
Pages (from-to)	311-314
Number of pages	4
Journal	Journal of Natural Products
Volume	78
Issue number	2
DOIs	https://doi.org/10.1021/np5006218
Publication status	Published - 2015 Feb 27
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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abstract = "Three new acridine alkaloids, inubosins A (1), B (2), and C (3), were isolated from an extract of a culture of Streptomyces sp. IFM 11440 using bioassay-guided fractionation. Neurogenin2 (Ngn2) is an activator-type basic helix-loop-helix transcription factor that promotes neural stem cell differentiation. Using cell-based Ngn2 promoter activity-guided screening, Streptomyces sp. IFM 11440 was found to induce Ngn2 promoter activity. The structures of 1-3 were established using spectroscopic methods, including 1D- and 2D-NMR measurements. Inubosin B (2) showed potent Ngn2 promoter activity. Moreover, inubosin B (2) increased mRNA expression of genes related to neural stem cell differentiation.",

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T1 - Inubosins A, B, and C are acridine alkaloids isolated from a culture of streptomyces sp. IFM 11440 with Ngn2 promoter activity

AU - Arai, Midori A.

AU - Koryudzu, Kazune

AU - Ishibashi, Masami

PY - 2015/2/27

Y1 - 2015/2/27

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AB - Three new acridine alkaloids, inubosins A (1), B (2), and C (3), were isolated from an extract of a culture of Streptomyces sp. IFM 11440 using bioassay-guided fractionation. Neurogenin2 (Ngn2) is an activator-type basic helix-loop-helix transcription factor that promotes neural stem cell differentiation. Using cell-based Ngn2 promoter activity-guided screening, Streptomyces sp. IFM 11440 was found to induce Ngn2 promoter activity. The structures of 1-3 were established using spectroscopic methods, including 1D- and 2D-NMR measurements. Inubosin B (2) showed potent Ngn2 promoter activity. Moreover, inubosin B (2) increased mRNA expression of genes related to neural stem cell differentiation.

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Inubosins A, B, and C are acridine alkaloids isolated from a culture of streptomyces sp. IFM 11440 with Ngn2 promoter activity

Abstract

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