Invasive hepatic mucormycosis

A case report and review of the literature

Daiki Karigane, Taku Kikuchi, Masatoshi Sakurai, Jun Kato, Yusuke Yamane, Risa Hashida, Ryohei Abe, Mami Hatano, Naoki Hasegawa, Megumi Wakayama, Kazutoshi Shibuya, Shinichiro Okamoto, Takehiko Mori

Research output: Contribution to journalArticle

Abstract

Mucormycosis generally develops under immunocompromised conditions, including hematological malignancies and solid organ or hematopoietic stem cell transplantation. Although mucormycosis usually affects the lungs and paranasal sinuses, sporadic cases of invasive mucormycosis of the liver have been reported. We hereby report a patient with myelofibrosis who developed hepatic mucormycosis diagnosed by post-mortem examination. An extensive literature review identified 13 reported cases of hepatic mucormycosis, including ours, without lung involvement. Most of the underlying diseases or conditions were hematological malignancies and solid organ transplantation. Three cases had splenic lesions and four had gastrointestinal lesions, suggesting the possibility of translocation to the liver and/or spleen from the gastrointestinal tracts. Hepatic mucormycosis should be recognized as one of the presentations of invasive mucormycosis, especially when hepatic nodules are found in immunocompromised patients such as those with hematological malignancy or recipients of solid organ transplantation.

Original languageEnglish
JournalJournal of Infection and Chemotherapy
DOIs
Publication statusAccepted/In press - 2018 Jan 1

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Mucormycosis
Liver
Hematologic Neoplasms
Organ Transplantation
Lung
Primary Myelofibrosis
Paranasal Sinuses
Hematopoietic Stem Cell Transplantation
Immunocompromised Host
Gastrointestinal Tract
Autopsy
Spleen

Keywords

  • Hepatic mucormycosis
  • Liver
  • Myelofibrosis
  • Solid organ transplantation

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Invasive hepatic mucormycosis : A case report and review of the literature. / Karigane, Daiki; Kikuchi, Taku; Sakurai, Masatoshi; Kato, Jun; Yamane, Yusuke; Hashida, Risa; Abe, Ryohei; Hatano, Mami; Hasegawa, Naoki; Wakayama, Megumi; Shibuya, Kazutoshi; Okamoto, Shinichiro; Mori, Takehiko.

In: Journal of Infection and Chemotherapy, 01.01.2018.

Research output: Contribution to journalArticle

Karigane, Daiki ; Kikuchi, Taku ; Sakurai, Masatoshi ; Kato, Jun ; Yamane, Yusuke ; Hashida, Risa ; Abe, Ryohei ; Hatano, Mami ; Hasegawa, Naoki ; Wakayama, Megumi ; Shibuya, Kazutoshi ; Okamoto, Shinichiro ; Mori, Takehiko. / Invasive hepatic mucormycosis : A case report and review of the literature. In: Journal of Infection and Chemotherapy. 2018.
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