Inversed relationship between CD44 variant and c-Myc due to oxidative stress-induced canonical Wnt activation

Go J. Yoshida, Hideyuki Saya

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)

Abstract

Cancer stem-like cells express high amount of CD44 variant8-10 which protects cancer cells from redox stress. We have demonstrated by immunohistochemical analysis and Western blotting, and reverse-transcription polymerase chain reaction, that CD44 variant8-10 and c-Myc tend to show the inversed expression manner in gastric cancer cells. That is attributable to the oxidative stress-induced canonical Wnt activation, and furthermore, the up-regulation of the downstream molecules, one of which is oncogenic c-Myc, is not easily to occur in CD44 variant-positive cancer cells. We have also found out that CD44v8-10 expression is associated with the turn-over of the c-Myc with the experiments using gastric cancer cell lines. This cannot be simply explained by the model of oxidative stress-induced Wnt activation. CD44v8-10-positive cancer cells are enriched at the invasive front. Tumor tissue at the invasive area is considered to be composed of heterogeneous cellular population; dormant cancer stem-like cells with CD44v8-10 high/ Fbw7 high/ c-Myc low and proliferative cancer stem-like cells with CD44v8-10 high/ Fbw7 low/ c-Myc high.

Original languageEnglish
Pages (from-to)622-627
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume443
Issue number2
DOIs
Publication statusPublished - 2014 Jan 10

Keywords

  • CD44 variant
  • Cancer stem-like cell
  • Fbw7
  • Gastric cancer
  • Redox stress-induced Wnt signal
  • c-Myc

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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