Investigating the effects of norepinephrine α1 receptor blockade on dopamine levels

A pilot PET study with [11C]-(+)-PHNO in controls

Bernard Le Foll, Thulasi Thiruchselvam, Shawna Xiaoyun Lu, Shakira Mohammed, Esmaeil Mansouri, Dina Lagzdins, Shinichiro Nakajima, Alan A. Wilson, Ariel Graff-Guerrero, Patricia Di Ciano, Isabelle Boileau

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Interest in a role for norepinephrine (NE) in substance use disorders has increased over recent years. In particular, its interaction with dopamine (DA) is of importance. In this study, positron emission tomography (PET) was used to explore the impact of prazosin (an alpha 1 NE antagonist) on DA levels. Healthy volunteers were administered prazosin for approximately 4 weeks at the daily dose of 15 mg to reach steady state. Participants were scanned with PET imaging and the [11C]-(+)-PHNO tracer at baseline (before prazosin), at steady state, and after a wash out period. Prazosin administration was associated with an increase of [11C]-(+)-PHNO binding potential in the dorsal caudate relative to baseline, which corresponds to a decrease in DA levels. This study is the first to demonstrate interactions between DA and NE in healthy humans.

Original languageEnglish
Article numbere21968
JournalSynapse
Volume71
Issue number7
DOIs
Publication statusPublished - 2017 Jul 1
Externally publishedYes

Fingerprint

Prazosin
Positron-Emission Tomography
Adrenergic Receptors
Dopamine
Norepinephrine
Dopamine Antagonists
Substance-Related Disorders
Healthy Volunteers
naxagolide

Keywords

  • dopamine
  • noradrenaline
  • PET
  • prazosin
  • [C]-(+)-PHNO

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Le Foll, B., Thiruchselvam, T., Lu, S. X., Mohammed, S., Mansouri, E., Lagzdins, D., ... Boileau, I. (2017). Investigating the effects of norepinephrine α1 receptor blockade on dopamine levels: A pilot PET study with [11C]-(+)-PHNO in controls. Synapse, 71(7), [e21968]. https://doi.org/10.1002/syn.21968

Investigating the effects of norepinephrine α1 receptor blockade on dopamine levels : A pilot PET study with [11C]-(+)-PHNO in controls. / Le Foll, Bernard; Thiruchselvam, Thulasi; Lu, Shawna Xiaoyun; Mohammed, Shakira; Mansouri, Esmaeil; Lagzdins, Dina; Nakajima, Shinichiro; Wilson, Alan A.; Graff-Guerrero, Ariel; Di Ciano, Patricia; Boileau, Isabelle.

In: Synapse, Vol. 71, No. 7, e21968, 01.07.2017.

Research output: Contribution to journalArticle

Le Foll, B, Thiruchselvam, T, Lu, SX, Mohammed, S, Mansouri, E, Lagzdins, D, Nakajima, S, Wilson, AA, Graff-Guerrero, A, Di Ciano, P & Boileau, I 2017, 'Investigating the effects of norepinephrine α1 receptor blockade on dopamine levels: A pilot PET study with [11C]-(+)-PHNO in controls', Synapse, vol. 71, no. 7, e21968. https://doi.org/10.1002/syn.21968
Le Foll, Bernard ; Thiruchselvam, Thulasi ; Lu, Shawna Xiaoyun ; Mohammed, Shakira ; Mansouri, Esmaeil ; Lagzdins, Dina ; Nakajima, Shinichiro ; Wilson, Alan A. ; Graff-Guerrero, Ariel ; Di Ciano, Patricia ; Boileau, Isabelle. / Investigating the effects of norepinephrine α1 receptor blockade on dopamine levels : A pilot PET study with [11C]-(+)-PHNO in controls. In: Synapse. 2017 ; Vol. 71, No. 7.
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