Investigation of β-lactam antibiotic-induced vancomycin-resistant MRSA (BIVR)

Hideaki Hanaki, Yoshio Yamaguchi, Chie Yanagisawa, Kazuaki Uehara, Hidehito Matsui, Yukie Yamaguchi, Yasuko Hososaka, Kazunari Barada, Fumiko Sakai, Yasuko Itabashi, Shinsuke Ikeda, Koichiro Atsuda, Haruo Tanaka, Takashi Inamatsu, Ariaki Nagayama, Keisuke Sunakawa

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

We could not detect hetero-vancomycin-intermediate resistant Staphylococcus aureus (hetero-VISA), according to the definition of hetero-VISA, from the clinical isolates of 140 methicillin-resistant S. aureus (MRSA) strains. However, 15 β-lactam antibiotic-induced vancomycin-resistant MRSA (BIVR) strains were detected from the same strains. We screened 1882 MRSA clinical isolates obtained in 2002 from 21 institutes throughout Japan. The detection rate of blood-isolated BIVR was 12.6% (19/151), and that of nonblood-isolated BIVR was 4.9% (85/1731; P < 0.001; χ2 test). Uridine-diphosphate-N-acetylmuramyl-L-alanyl-D-isoglutamyl-L-lysine, used as the peptidoglycan material of S. aureus, showed the same results as β-lactam antibiotics in BIVR.

Original languageEnglish
Pages (from-to)104-106
Number of pages3
JournalJournal of Infection and Chemotherapy
Volume11
Issue number2
DOIs
Publication statusPublished - 2005 Apr
Externally publishedYes

Keywords

  • Antagonism
  • BIVR
  • Vancomycin
  • β-Lactam antibiotics

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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