Investigation of brain science and neurological/psychiatric disorders using genetically modified non-human primates

Hideyuki Okano, Noriyuki Kishi

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Although mice have been the most frequently used experimental animals in many research fields due to well-established gene manipulation techniques, recent evidence has revealed that rodent models do not always recapitulate pathophysiology of human neurological and psychiatric diseases due to the differences between humans and rodents. The recent developments in gene manipulation of non-human primate have been attracting much attention in the biomedical research field, because non-human primates have more applicable brain structure and function than rodents. In this review, we summarize recent progress on genetically-modified non-human primates including transgenic and knockout animals using genome editing technology.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalCurrent Opinion in Neurobiology
Volume50
DOIs
Publication statusPublished - 2018 Jun 1

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ASJC Scopus subject areas

  • Neuroscience(all)

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