Investigation of the effect of discrete absorbers upon the measurement of blood volume with near-infrared spectroscopy

Michael Firbank, Eiji Okada, David T. Delpy

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

This paper derives an analytical model for investigating the effect of the distribution of absorbers upon light attenuation in a scattering medium. Results from this are found to agree with those of Monte Carlo simulations. The implications of this model are then examined for their likely effect upon the measurement of cerebral blood volume (CBV) using near-infrared (NIR) spectroscopy. We conclude that, given the small diameter of the majority of cerebral blood vessels, the distribution of the blood will have little effect upon the measurement of CBV. Where changes to the blood volume occur in the larger (>0.2 mm diameter) vessels on the surface of the brain, NIR spectroscopy is likely to underestimate the change.

Original languageEnglish
Pages (from-to)465-477
Number of pages13
JournalPhysics in Medicine and Biology
Volume42
Issue number3
DOIs
Publication statusPublished - 1997
Externally publishedYes

Fingerprint

blood volume
Near infrared spectroscopy
Near-Infrared Spectroscopy
Blood Volume
absorbers
Blood
infrared spectroscopy
Blood Vessels
blood vessels
Light
blood
brain
vessels
Blood vessels
Brain
attenuation
Analytical models
Scattering
scattering
Cerebral Blood Volume

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physics and Astronomy (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Investigation of the effect of discrete absorbers upon the measurement of blood volume with near-infrared spectroscopy. / Firbank, Michael; Okada, Eiji; Delpy, David T.

In: Physics in Medicine and Biology, Vol. 42, No. 3, 1997, p. 465-477.

Research output: Contribution to journalArticle

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