Investigation of the effect of discrete absorbers upon the measurement of blood volume with near-infrared spectroscopy

Michael Firbank; Eiji Okada; David T. Delpy

doi:10.1088/0031-9155/42/3/002

Investigation of the effect of discrete absorbers upon the measurement of blood volume with near-infrared spectroscopy

Michael Firbank, Eiji Okada, David T. Delpy

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

This paper derives an analytical model for investigating the effect of the distribution of absorbers upon light attenuation in a scattering medium. Results from this are found to agree with those of Monte Carlo simulations. The implications of this model are then examined for their likely effect upon the measurement of cerebral blood volume (CBV) using near-infrared (NIR) spectroscopy. We conclude that, given the small diameter of the majority of cerebral blood vessels, the distribution of the blood will have little effect upon the measurement of CBV. Where changes to the blood volume occur in the larger (>0.2 mm diameter) vessels on the surface of the brain, NIR spectroscopy is likely to underestimate the change.

Original language	English
Pages (from-to)	465-477
Number of pages	13
Journal	Physics in Medicine and Biology
Volume	42
Issue number	3
DOIs	https://doi.org/10.1088/0031-9155/42/3/002
Publication status	Published - 1997
Externally published	Yes

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

Access to Document

10.1088/0031-9155/42/3/002

Fingerprint Dive into the research topics of 'Investigation of the effect of discrete absorbers upon the measurement of blood volume with near-infrared spectroscopy'. Together they form a unique fingerprint.

Cite this

@article{9d04f04993224dbd9a67543d6cbfc75f,

title = "Investigation of the effect of discrete absorbers upon the measurement of blood volume with near-infrared spectroscopy",

abstract = "This paper derives an analytical model for investigating the effect of the distribution of absorbers upon light attenuation in a scattering medium. Results from this are found to agree with those of Monte Carlo simulations. The implications of this model are then examined for their likely effect upon the measurement of cerebral blood volume (CBV) using near-infrared (NIR) spectroscopy. We conclude that, given the small diameter of the majority of cerebral blood vessels, the distribution of the blood will have little effect upon the measurement of CBV. Where changes to the blood volume occur in the larger (>0.2 mm diameter) vessels on the surface of the brain, NIR spectroscopy is likely to underestimate the change.",

author = "Michael Firbank and Eiji Okada and Delpy, {David T.}",

year = "1997",

doi = "10.1088/0031-9155/42/3/002",

language = "English",

volume = "42",

pages = "465--477",

journal = "Physics in Medicine and Biology",

issn = "0031-9155",

publisher = "IOP Publishing Ltd.",

number = "3",

}

TY - JOUR

T1 - Investigation of the effect of discrete absorbers upon the measurement of blood volume with near-infrared spectroscopy

AU - Firbank, Michael

AU - Okada, Eiji

AU - Delpy, David T.

PY - 1997

Y1 - 1997

N2 - This paper derives an analytical model for investigating the effect of the distribution of absorbers upon light attenuation in a scattering medium. Results from this are found to agree with those of Monte Carlo simulations. The implications of this model are then examined for their likely effect upon the measurement of cerebral blood volume (CBV) using near-infrared (NIR) spectroscopy. We conclude that, given the small diameter of the majority of cerebral blood vessels, the distribution of the blood will have little effect upon the measurement of CBV. Where changes to the blood volume occur in the larger (>0.2 mm diameter) vessels on the surface of the brain, NIR spectroscopy is likely to underestimate the change.

AB - This paper derives an analytical model for investigating the effect of the distribution of absorbers upon light attenuation in a scattering medium. Results from this are found to agree with those of Monte Carlo simulations. The implications of this model are then examined for their likely effect upon the measurement of cerebral blood volume (CBV) using near-infrared (NIR) spectroscopy. We conclude that, given the small diameter of the majority of cerebral blood vessels, the distribution of the blood will have little effect upon the measurement of CBV. Where changes to the blood volume occur in the larger (>0.2 mm diameter) vessels on the surface of the brain, NIR spectroscopy is likely to underestimate the change.

UR - http://www.scopus.com/inward/record.url?scp=0030972932&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030972932&partnerID=8YFLogxK

U2 - 10.1088/0031-9155/42/3/002

DO - 10.1088/0031-9155/42/3/002

M3 - Article

C2 - 9080529

AN - SCOPUS:0030972932

VL - 42

SP - 465

EP - 477

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

SN - 0031-9155

IS - 3

ER -

Investigation of the effect of discrete absorbers upon the measurement of blood volume with near-infrared spectroscopy

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this