Investigation of the effect of discrete absorbers upon the measurement of blood volume with near-infrared spectroscopy

Michael Firbank; Eiji Okada; David T. Delpy

doi:10.1088/0031-9155/42/3/002

Investigation of the effect of discrete absorbers upon the measurement of blood volume with near-infrared spectroscopy

Michael Firbank, Eiji Okada, David T. Delpy

Department of Electronics and Electrical Engineering

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

This paper derives an analytical model for investigating the effect of the distribution of absorbers upon light attenuation in a scattering medium. Results from this are found to agree with those of Monte Carlo simulations. The implications of this model are then examined for their likely effect upon the measurement of cerebral blood volume (CBV) using near-infrared (NIR) spectroscopy. We conclude that, given the small diameter of the majority of cerebral blood vessels, the distribution of the blood will have little effect upon the measurement of CBV. Where changes to the blood volume occur in the larger (>0.2 mm diameter) vessels on the surface of the brain, NIR spectroscopy is likely to underestimate the change.

Original language	English
Pages (from-to)	465-477
Number of pages	13
Journal	Physics in Medicine and Biology
Volume	42
Issue number	3
DOIs	https://doi.org/10.1088/0031-9155/42/3/002
Publication status	Published - 1997

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

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AB - This paper derives an analytical model for investigating the effect of the distribution of absorbers upon light attenuation in a scattering medium. Results from this are found to agree with those of Monte Carlo simulations. The implications of this model are then examined for their likely effect upon the measurement of cerebral blood volume (CBV) using near-infrared (NIR) spectroscopy. We conclude that, given the small diameter of the majority of cerebral blood vessels, the distribution of the blood will have little effect upon the measurement of CBV. Where changes to the blood volume occur in the larger (>0.2 mm diameter) vessels on the surface of the brain, NIR spectroscopy is likely to underestimate the change.

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