Abstract
This paper derives an analytical model for investigating the effect of the distribution of absorbers upon light attenuation in a scattering medium. Results from this are found to agree with those of Monte Carlo simulations. The implications of this model are then examined for their likely effect upon the measurement of cerebral blood volume (CBV) using near-infrared (NIR) spectroscopy. We conclude that, given the small diameter of the majority of cerebral blood vessels, the distribution of the blood will have little effect upon the measurement of CBV. Where changes to the blood volume occur in the larger (>0.2 mm diameter) vessels on the surface of the brain, NIR spectroscopy is likely to underestimate the change.
| Original language | English |
|---|---|
| Pages (from-to) | 465-477 |
| Number of pages | 13 |
| Journal | Physics in Medicine and Biology |
| Volume | 42 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1997 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biomedical Engineering
- Physics and Astronomy (miscellaneous)
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
Investigation of the effect of discrete absorbers upon the measurement of blood volume with near-infrared spectroscopy. / Firbank, Michael; Okada, Eiji; Delpy, David T.
In: Physics in Medicine and Biology, Vol. 42, No. 3, 1997, p. 465-477.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Investigation of the effect of discrete absorbers upon the measurement of blood volume with near-infrared spectroscopy
AU - Firbank, Michael
AU - Okada, Eiji
AU - Delpy, David T.
PY - 1997
Y1 - 1997
N2 - This paper derives an analytical model for investigating the effect of the distribution of absorbers upon light attenuation in a scattering medium. Results from this are found to agree with those of Monte Carlo simulations. The implications of this model are then examined for their likely effect upon the measurement of cerebral blood volume (CBV) using near-infrared (NIR) spectroscopy. We conclude that, given the small diameter of the majority of cerebral blood vessels, the distribution of the blood will have little effect upon the measurement of CBV. Where changes to the blood volume occur in the larger (>0.2 mm diameter) vessels on the surface of the brain, NIR spectroscopy is likely to underestimate the change.
AB - This paper derives an analytical model for investigating the effect of the distribution of absorbers upon light attenuation in a scattering medium. Results from this are found to agree with those of Monte Carlo simulations. The implications of this model are then examined for their likely effect upon the measurement of cerebral blood volume (CBV) using near-infrared (NIR) spectroscopy. We conclude that, given the small diameter of the majority of cerebral blood vessels, the distribution of the blood will have little effect upon the measurement of CBV. Where changes to the blood volume occur in the larger (>0.2 mm diameter) vessels on the surface of the brain, NIR spectroscopy is likely to underestimate the change.
UR - http://www.scopus.com/inward/record.url?scp=0030972932&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030972932&partnerID=8YFLogxK
U2 - 10.1088/0031-9155/42/3/002
DO - 10.1088/0031-9155/42/3/002
M3 - Article
C2 - 9080529
AN - SCOPUS:0030972932
VL - 42
SP - 465
EP - 477
JO - Physics in Medicine and Biology
JF - Physics in Medicine and Biology
SN - 0031-9155
IS - 3
ER -