Investigation of the effect of discrete scatterers in CSF layer on optical path length in the brain

Eiji Okada, David T. Delpy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Citations (Scopus)

Abstract

Adequate modelling of light propagation in the complex and heterogeneous tissue of the human head is very important for quantitative near infrared spectroscopy and optical imaging. The presence of a clear and non-scattering CSF layer around the brain has been previously shown to strongly affect light propagation in the head. However the CSF layer is not totally filled with a non-scattering fluid and quite a few fine arachnoid trabeculae are actually present in the layer. In this study light propagation in an adult head model with discrete scatterers distributed within the CSF layer has been predicted by Monte Carlo simulation in order to investigate the effect of scattering caused by the arachnoid trabeculae in the CSF layer. Results show that the presence of the arachnoid trabeculae affect the total optical path length, a parameter which can be directly measured by time-resolved measurement. However, the partial optical path length in the brain tissue, which relates the sensitivity of the near infrared spectroscopy signal to absorption changes in the brain is strongly affected by the CSF layer even in the presence of the arachnoid trabeculae. The increased partial optical path length results from an increased lateral spreading of the NIR light within the grey matter of the cortex.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Pages196-203
Number of pages8
Volume4160
DOIs
Publication statusPublished - 2000
EventPhoton Migration, Diffuse Spectroscopy, and Optical Coherence Tomography: Imaging and Functional Assessment - Amsterdam, Neth
Duration: 2000 Jul 62000 Jul 8

Other

OtherPhoton Migration, Diffuse Spectroscopy, and Optical Coherence Tomography: Imaging and Functional Assessment
CityAmsterdam, Neth
Period00/7/600/7/8

Fingerprint

Light propagation
optical paths
brain
Brain
Near infrared spectroscopy
scattering
Tissue
Time measurement
propagation
infrared spectroscopy
Scattering
Imaging techniques
Fluids
cortexes
time measurement
fluids
sensitivity
simulation

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Okada, E., & Delpy, D. T. (2000). Investigation of the effect of discrete scatterers in CSF layer on optical path length in the brain. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4160, pp. 196-203). Society of Photo-Optical Instrumentation Engineers. https://doi.org/10.1117/12.407621

Investigation of the effect of discrete scatterers in CSF layer on optical path length in the brain. / Okada, Eiji; Delpy, David T.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4160 Society of Photo-Optical Instrumentation Engineers, 2000. p. 196-203.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Okada, E & Delpy, DT 2000, Investigation of the effect of discrete scatterers in CSF layer on optical path length in the brain. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 4160, Society of Photo-Optical Instrumentation Engineers, pp. 196-203, Photon Migration, Diffuse Spectroscopy, and Optical Coherence Tomography: Imaging and Functional Assessment, Amsterdam, Neth, 00/7/6. https://doi.org/10.1117/12.407621
Okada E, Delpy DT. Investigation of the effect of discrete scatterers in CSF layer on optical path length in the brain. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4160. Society of Photo-Optical Instrumentation Engineers. 2000. p. 196-203 https://doi.org/10.1117/12.407621
Okada, Eiji ; Delpy, David T. / Investigation of the effect of discrete scatterers in CSF layer on optical path length in the brain. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4160 Society of Photo-Optical Instrumentation Engineers, 2000. pp. 196-203
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