Involvement of astrocytes in neurovascular communication

Mutsuo Nuriya, H. Hirase

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The vascular interface of the brain is distinct from that of the peripheral tissue in that astrocytes, the most numerous glial cell type in the gray matter, cover the vasculature with their endfeet. This morphological feature of the gliovascular junction has prompted neuroscientists to suggest possible functional roles of astrocytes including astrocytic modulation of the vasculature. Additionally, astrocytes develop an intricate morphology that intimately apposes neuronal synapses, making them an ideal cellular mediator of neurovascular coupling. In this article, we first introduce the classical anatomical and physiological findings that led to the proposal of various gliovascular interaction models. Next, we touch on the technological advances in the past few decades that enabled investigations and evaluations of neuro-glio-vascular interactions in situ. We then review recent experimental findings on the roles of astrocytes in neurovascular coupling from the viewpoints of intra- and intercellular signalings in astrocytes.

Original languageEnglish
JournalProgress in Brain Research
DOIs
Publication statusAccepted/In press - 2016

Fingerprint

Astrocytes
Blood Vessels
Neuroglia
Synapses
Brain
Neurovascular Coupling

Keywords

  • AQP4
  • Astrocyte
  • Calcium
  • Endfeet
  • Gap junction
  • Neurovascular coupling
  • Potassium

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Involvement of astrocytes in neurovascular communication. / Nuriya, Mutsuo; Hirase, H.

In: Progress in Brain Research, 2016.

Research output: Contribution to journalArticle

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