Involvement of NF-κB-mediated expression of galectin-3- binding protein in TNF-α-induced breast cancer cell adhesion

Naruto Noma, Siro Simizu, Yusuke Kambayashi, Yasuaki Kabe, Makoto Suematsu, Kazuo Umezawa

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Galectin-3-binding protein (G3BP) is highly expressed in various types of cancer and is thought to be involved in cancer malignancy; however, the role of G3BP in breast cancer cells is not fully understood. In this study, we investigated the role of NF-κB in the adhesion of breast cancer cells to a substrate by using (-)-DHMEQ, a specific inhibitor of NF-κB. (-)-DHMEQ inhibited both TNF-α-induced G3BP expression and cell adhesion in human breast cancer cell lines. We also found that knockdown of G3BP suppressed the adhesion, while its overexpression increased the adhesion. These data reveal that (-)-DHMEQ suppresses breast cancer cell adhesion by inhibiting NF-κB-regulated G3BP expression.

Original languageEnglish
Pages (from-to)2080-2084
Number of pages5
JournalOncology reports
Volume27
Issue number6
DOIs
Publication statusPublished - 2012 Jun

Keywords

  • Adhesion
  • Breast cancer
  • Galectin-3-binding protein
  • NF-κB

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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